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Product Name: Clinafloxacin Hydrochloride
Synonyms: CL-960, Clinafloxacin HCl
CAS Number: 105956-29-8
Chemical Family: Fluoroquinolone antibacterial
Intended Use: Laboratory chemical, research and development
Manufacturer: [Contact relevant supplier or manufacturer]
Emergency Contact: [Insert Emergency contact phone number and address]
GHS Classification: Acute oral toxicity, Eye irritation, Skin irritation, Hazardous to aquatic environment
Signal Word: Warning
Hazard Statements: May cause respiratory irritation, causes mild skin and eye irritation, toxic to aquatic life with long lasting effects, may damage fertility or the unborn child
Pictograms: Exclamation mark, Health hazard, Environment
Precautionary Statements: Avoid breathing dust or fumes, wash hands thoroughly after handling, use personal protective equipment as required, avoid release into the environment
Chemical Name: Clinafloxacin Hydrochloride
Formula: C17H17ClFN3O4•HCl
Concentration: ≥ 98% as supplied
Impurities: Trace process impurities & residual solvents at low ppm levels
Other Ingredients: No stabilizers, excipients, or additives detected above reporting limits
Inhalation: Move to fresh air, keep at rest, seek medical attention if symptoms such as cough or shortness of breath linger
Skin Contact: Remove contaminated clothing, wash with soap and water, consult a physician if irritation or rash appears
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, seek medical advice
Ingestion: Rinse mouth, drink water, do not induce vomiting unless instructed by medical personnel, call poison control center
Most Important Symptoms: Eye, skin, or airway irritation; gastrointestinal discomfort; allergic reactions in sensitive individuals
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Media: High-pressure water jets may scatter material
Specific Hazards: Decomposition yields toxic fumes such as nitrogen oxides, hydrogen chloride, hydrogen fluoride, carbon oxides
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing
Special Procedures: Move containers from fire zone if possible, avoid inhalation of combustion products
Personal Precautions: Use personal protective gear such as gloves, goggles, lab coat, and dust respirator
Environmental Precautions: Do not allow material to enter drains or waterways
Cleanup Methods: Scoop up spilled powder mechanically, minimize dust, sweep or vacuum using equipment fitted with HEPA filters, place in appropriate waste disposal container
Decontamination: Clean spill area with water and detergent, ventilate area thoroughly before reuse
Reporting: Notify relevant authorities if release causes significant environmental contamination
Handling: Avoid exposure by inhalation, skin or eye contact, use only with adequate ventilation, practice good hygiene after handling, keep away from food and beverages
Storage: Store in tightly sealed original containers, protected from direct sunlight, at 2 – 8 °C in a cool, dry, and well-ventilated area, segregate from strong oxidizers and acids
Incompatible Materials: Strong acids, strong bases, oxidizing agents, reducing agents
Other Precautions: Store away from sources of ignition, keep container tightly closed when not in use
Engineering Controls: Work in a chemical fume hood or area with local exhaust ventilation, use closed systems for large-scale work
Respiratory Protection: NIOSH-approved particulate respirator if dust becomes airborne
Eye Protection: Chemical safety goggles or face shield
Skin Protection: Laboratory gloves and appropriate protective clothing, ensure glove compatibility
Hygiene Measures: Wash hands before breaks and after final handling, do not eat, drink, or smoke where product is handled
Appearance: Off-white to light yellow powder
Odor: Odorless to faint chemical odor
pH (1% solution): 4.0 – 6.0
Melting Point: 220 – 228 °C (decomposes)
Solubility: Freely soluble in water, moderately soluble in methanol, insoluble in hexane
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not highly flammable
Vapor Pressure: Negligible at ambient conditions
Relative Density: 1.4 – 1.5 g/cm3
Partition Coefficient (log Kow): ~ 1.1
Other Data: Non-volatile solid; stable at ambient conditions for short periods
Chemical Stability: Stable under recommended storage, decomposes at high temperatures
Conditions to Avoid: Exposure to high temperature, moisture, strong light
Incompatible Materials: Strong oxidizers, strong bases, acids, reducing agents
Hazardous Decomposition: Nitrogen oxides, hydrogen chloride, hydrogen fluoride, carbon monoxide, carbon dioxide
Hazardous Polymerization: Not known to occur under normal use
Routes of Exposure: Inhalation, ingestion, dermal contact, ocular exposure
Acute Effects: Irritation of skin, eyes, and upper respiratory tract, gastrointestinal symptoms such as nausea, vomiting, diarrhea
Chronic Effects: Photosensitivity, potential for blood dyscrasia, possible reproductive effects based on animal studies
LD50 (oral, rat): 250 – 500 mg/kg (estimated)
Mutagenicity: Mixed results in classic genotoxicity assays
Carcinogenicity: Not listed by IARC, NTP, or OSHA; long-term studies in animals limited
Other Health Hazards: Allergic reactions; not for use in pregnancy unless benefits outweigh potential risk
Ecotoxicity: Highly toxic to aquatic organisms at low concentrations, possible risk of long-term adverse effects in the aquatic environment
Persistence and Degradability: Moderate persistence, partial biodegradation in wastewater but some risk of bioaccumulation in aquatic species
Mobility in Soil: Likely mobile; potential for groundwater contamination
Bioaccumulation: Possible based on physicochemical properties; limited data on environmental fate
Other Adverse Effects: Antibiotic contamination can disrupt microbial communities in soil and water
Waste Disposal Methods: Treat as hazardous pharmaceutical waste, incinerate in approved facility, do not empty into drains, dispose of in accordance with local, regional, and national regulations
Contaminated Packaging: Decontaminate and recycle where possible or dispose of as hazardous waste
Regulator Guidance: Consult environmental agency or waste authority for detailed instructions
Special Precautions: Minimize generation of waste, do not attempt disposal by pouring down the sink or in municipal trash
UN Number: Unassigned
UN Proper Shipping Name: Not regulated as dangerous for transport under IATA, ADR, or DOT
Transport Hazard Class: Non-hazardous chemical cargo
Packing Group: Not applicable
Other Information: Protect from direct sunlight and moisture; ensure containers remain tightly sealed during transit
Safety, Health, and Environmental: Complies with OSHA Hazard Communication Standard, Canada WHMIS, EU REACH where applicable
Inventory Status: Listed or notified in select chemical inventories, check regionally
SARA Title III – Section 313: Not listed
California Prop 65: Not listed
Workplace Labeling: Required for quantities handled outside original packaging, ensure all secondary containers comply
Other Regulations: Laboratory use only – not for human or veterinary medical use without appropriate regulatory approvals and compliance with local legislation
