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Product Name: Climbazole
Chemical Name: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Synonyms: 4-Chlorophenoxy-2,4-dimethyl-1H-imidazole-1-ylpropanone
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.8 g/mol
CAS Number: 38083-17-9
Recommended Use: Anti-fungal agent in personal care products like shampoos and creams
Supplier Contact: Emergency phone number, address, and company details
Classification: Skin irritant, Eye irritant, Aquatic toxicant (Chronic and Acute)
Hazard Statements: Causes skin and serious eye irritation. Harmful if swallowed. Toxic to aquatic life with long-lasting effects.
Pictograms: Exclamation mark, Environment
Precautionary Statements: Wear protective gloves and eye protection. Avoid release into the environment. Wash hands after handling. If swallowed, seek medical advice immediately.
Chemical-based Ingredient: Climbazole
Ingredient Concentration: 98-100% (technical grade)
Impurities: Trace amounts of synthetic byproducts, not considered relevant for classification
Other Components: No other hazardous components present above disclosure thresholds.
Inhalation: Move to fresh air. Keep person at rest. If breathing becomes difficult, call medical help.
Skin Contact: Rinse with plenty of water. Remove contaminated clothing. If skin irritation persists, seek medical advice.
Eye Contact: Rinse gently with water for several minutes. Remove contacts if present. Continue rinsing. Obtain medical attention if symptoms persist.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Seek immediate medical attention if large quantities swallowed.
Most Important Symptoms: Burning, redness, itching, gastrointestinal upset
Extinguishing Methods: Use water spray, dry chemical powder, carbon dioxide, or foam.
Unusual Fire & Explosion Hazards: Combustion releases toxic fumes of chlorine compounds, nitrogen oxides, carbon oxides.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective clothing.
Advice for Firefighters: Contain run-off to prevent environmental contamination. Avoid inhalation of combustion products.
Personal Precautions: Do not touch or walk through spilled material. Wear suitable protective clothing, gloves, and eye/face protection.
Environmental Precautions: Prevent entry into drains, surface water, and soil.
Cleanup Methods: Collect spillage with non-combustible absorbent material (sand, earth, vermiculite). Place in a chemical waste container for disposal.
Decontamination: Wash the site of the spill with plenty of water and detergent. Dispose of washings as hazardous waste.
Handling: Avoid dust formation. Avoid inhalation, ingestion, and contact with skin and eyes. Use only in well-ventilated areas. Wear suitable personal protective equipment.
Storage: Store in tightly closed container, in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers and acids. Keep away from heat and open flame. Protect from moisture.
Control Parameters: No specific occupational exposure limit value. Maintain airborne concentrations as low as reasonably achievable.
Engineering Controls: Use appropriate exhaust ventilation at places where dust is formed.
Personal Protective Equipment:
- Respiratory Protection: Use approved dust mask or respirator if exposure limits are exceeded or irritation is experienced.
- Skin Protection: Wear chemical-resistant gloves, long-sleeved clothing.
- Eye/Face Protection: Use safety goggles or face shield.
- General Protection: Do not eat, drink, or smoke during handling. Wash hands before breaks and at end of work.
Appearance: White crystalline powder
Odor: Odorless
Melting Point: 96 – 99°C
Boiling Point: Not determined
Density: Approx. 1.23 g/cm³
Solubility: Practically insoluble in water; soluble in alcohols and acetone
Vapor Pressure: Negligible at room temperature
pH: Not applicable
Partition Coefficient (log Kow): 2.9
Flash Point: Not flammable under normal conditions
Auto-ignition Temperature: Not available
Chemical Stability: Stable under normal storage and handling conditions.
Hazardous Reactions: No dangerous reactions known under recommended storage and use.
Incompatible Materials: Strong oxidizing agents, acids, strong bases.
Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, nitrogen oxides under fire conditions.
Polymerization: Product will not undergo hazardous polymerization.
Acute Toxicity: LD50 (oral, rat) > 2000 mg/kg; relatively low toxicity.
Skin Corrosion/Irritation: Causes irritation with prolonged contact.
Eye Damage/Irritation: Causes serious eye irritation.
Respiratory Sensitization: May cause respiratory irritation if inhaled.
Carcinogenicity: No data proving carcinogenic effects.
Mutagenicity: Not classified as mutagenic.
Reproductive Toxicity: Not classified as toxic for reproduction.
Specific Target Organ Toxicity: Not expected at occupational exposure levels.
Aquatic Toxicity: Toxic to aquatic life. LC50 values for fish: 0.5 – 1 mg/L.
Persistence and Degradability: Biodegradation is limited; stays in environment for long durations.
Bioaccumulative Potential: Potential to bioaccumulate in aquatic organisms.
Mobility in Soil: Low mobility, binds strongly to soil.
Other Adverse Effects: Avoid contamination of natural waters and soil with waste or unused product.
Disposal Methods: Dispose in accordance with national, regional, and local regulations. Do not discharge into drains or environment.
Container Disposal: Triple rinse and offer for recycling or dispose as hazardous chemical waste.
Special Precautions: Handle contaminated packaging with the same precautions as the product. Label waste for compliance.
UN Number: Not regulated for ground or air transport under most jurisdictions.
Proper Shipping Name: Not classified as dangerous good.
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Marine pollutant by potential, take care with large quantities.
Special Precautions: Keep packaged tightly closed, clearly labeled, and away from food and feed.
Global Inventory Status: Listed in key chemical inventories (EU REACH, TSCA, AICS, DSL, ENCS).
Classification: Classified as hazardous as per GHS and CLP regulations.
Label Elements: Warning pictograms and phrases according to local chemical safety laws.
Applicable Directives: Cosmetic safety regulations restrict Climbazole use levels. Occupational safety and health laws may apply for large-scale manufacturing environments.
Other Regulatory Limits: Restrictions for discharge in wastewater; tighter rules in regions with sensitive aquatic environments.
