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Material Safety Data Sheet (MSDS) for Citicoline Sodium

Identification

Product Name: Citicoline Sodium
Chemical Name: Cytidine 5'-diphosphocholine sodium salt
Synonyms: CDP Choline Sodium, Cytidine-5'-diphosphocholine sodium salt
CAS Number: 33818-15-4
Molecular Formula: C14H25N4NaO11P2
Molecular Weight: 510.31 g/mol
Recommended Use: Nootropic, nutritional supplement, pharmaceutical intermediate
Supplier: [Redacted for privacy]
Contact Information: [Redacted for privacy]
Emergency Phone Number: [Redacted for privacy]

Hazard Identification

GHS Classification: Not classified as hazardous under GHS criteria
Main Hazards: May cause mild irritation to eyes, skin, respiratory tract
Health Effects: Prolonged exposure: mild discomfort above certain thresholds; ingestion or inhalation: nausea, headache possible in sensitive individuals; no chronic effects expected at normal workplace exposure levels
Environmental Effects: Low impact, not listed as a marine pollutant
Label Elements: No pictogram or signal word required
Precautionary Statements: Wash hands after handling; avoid contact with eyes, skin, and clothing; avoid breathing dust

Composition / Information on Ingredients

Chemical: Citicoline Sodium
Concentration: ≥98% (by weight)
Impurities: Water (<2%), trace organic/by-product residues
Additional Components: None reported
EINECS Number: 251-689-1

First Aid Measures

Inhalation: Move to fresh air; seek medical attention for symptoms such as cough, dizziness, or breathing difficulty
Eye Contact: Rinse slowly with water while holding eyelids open; remove contact lenses if present
Skin Contact: Wash exposed skin with soap and water
Ingestion: Rinse mouth, drink water if conscious; seek medical advice if large quantities ingested or if discomfort persists
Notes for Physicians: Treat symptomatically, no specific antidote indicated

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Specific Hazards: Combustion generates oxides of carbon, nitrogen, and phosphorus; low fire risk in powder form
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear
Special Procedures: Cool containers with water; avoid inhaling smoke, fumes, or vapors

Accidental Release Measures

Personal Precautions: Use personal protective equipment such as gloves and safety glasses; avoid dust formation and inhalation
Environmental Precautions: Prevent large amounts from entering drains, sewers, or waterways
Clean-Up Methods: Sweep or vacuum up material, avoid raising dust; place in sealed containers for disposal
Decontamination: Wash spill site with water after material pickup is complete

Handling and Storage

Handling: Use in well-ventilated areas; avoid breathing in dust; minimize skin and eye contact
Technical Measures: Keep containers tightly closed and clearly labeled
Hygienic Practices: Do not eat, drink, or smoke while handling; wash hands thoroughly after handling
Storage Conditions: Store at room temperature, away from moisture and direct sunlight; store in original container or equivalent, keep away from incompatible materials (strong acids, oxidizers)
Incompatibilities: Strong oxidizing agents, acids

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established limits by OSHA, ACGIH, or NIOSH for this substance
Engineering Controls: Use local exhaust ventilation to control dust levels
Personal Protection: Gloves, lab coat, safety glasses or goggles, dust mask or respirator (N95 or equivalent) when exposure cannot be controlled by ventilation alone
Environmental Controls: Avoid release to the environment, provide spill containment

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
pH (1% solution): 6.5-7.5
Melting Point: Decomposes above 200°C
Solubility: Highly soluble in water, slightly soluble in ethanol, nearly insoluble in organic solvents
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not applicable
Relative Density: Approximately 1.8 g/cm3
Partition Coefficient: Not available
Auto-ignition Temperature: Not determined
Flash Point: Not flammable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal use
Decomposition: May release toxic fumes under fire conditions (phosphorus oxides, nitrogen oxides, carbon oxides)
Incompatible Materials: Strong acids, oxidizing agents
Hazardous Polymerization: Will not occur

Toxicological Information

Acute Toxicity: Low; oral LD50 (rat) >5000 mg/kg
Skin Corrosion/Irritation: Mild skin irritation reported at high exposures
Serious Eye Damage/Irritation: Mild eye irritation after direct contact
Respiratory Sensitization: Not a sensitizer based on available data
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No evidence of genotoxicity in common test systems
Chronic Effects: No chronic toxicity observed in animal studies at occupational exposure levels

Ecological Information

Ecotoxicity: Not classified as hazardous to aquatic life; low acute toxicity to fish and daphnia
Persistence and Degradability: Biodegradable under standard conditions
Bioaccumulation: Potential for bioaccumulation is low
Mobility in Soil: High water solubility suggests rapid dispersion and low risk of bioaccumulation
Other Adverse Effects: Not expected to cause significant environmental harm at released levels

Disposal Considerations

Waste Disposal: Dispose of in accordance with local, regional, and national regulations; small quantities can go to landfill with non-hazardous chemical waste, large quantities treated as pharmaceutical waste
Container Disposal: Triple-rinse containers before discarding; puncture and dispose through licensed disposal contractor
Recommended Methods: Incineration at approved facility or approved chemical waste treatment

Transport Information

UN Number: Not regulated for transport
Proper Shipping Name: Not applicable
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: No specific hazards identified during transport
Special Precautions: Protect from physical damage, moisture during transit; avoid temperature extremes

Regulatory Information

US Regulation: Not listed as hazardous under OSHA Hazard Communication, TSCA inventory, CERCLA, SARA, or RCRA
EU Regulation: Not classified as dangerous under Regulation (EC) 1272/2008, REACH registered
Other International Regulation: Not subject to specific requirements under Canadian DSL/NDSL, Japanese ENCS, or Australian AICS
Labelling Requirements: General chemical labeling; no specific hazard pictograms or signal words
Workplace Controls: General good hygiene and industrial practices apply to handling and storage