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Product Name: Cisplatin
Chemical Name: cis-Diamminedichloroplatinum(II)
Synonyms: CDDP, Platinol, cisplatinum
CAS Number: 15663-27-1
Molecular Formula: Cl2H6N2Pt
Manufacturer: Refer to primary supplier information
Recommended Use: Chemotherapeutic agent for oncology purposes
Emergency Phone Number: Refer to regional poison control or medical emergency contacts
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin sensitization, carcinogenic potential, germ cell mutagenicity
Signal Word: Danger
Hazard Statements: Causes severe skin irritation, serious eye damage, may cause allergy or asthma symptoms if inhaled, suspected of causing genetic defects, confirmed human carcinogen, toxic to aquatic life
Precautionary Statements: Avoid all unnecessary contact, use only with appropriate safety gear, prevent environmental release
Route of Exposure: Inhalation, ingestion, skin contact, eye contact
Target Organs: Kidneys, bone marrow, liver
Cisplatin: 98–100%
Chemical Formula: Cl2H6N2Pt
Impurities: May contain trace quantities of related platinum compounds
Exposure Limits: Consult lists from OSHA, NIOSH, ACGIH based on platinum compound guidelines
Inhalation: Remove person to fresh air, keep warm and comfortable, provide oxygen if breathing is difficult, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes, wash with mild soap and water, consult physician immediately
Eye Contact: Flush eyes with clean running water for several minutes, remove contact lenses gently, seek emergency medical evaluation
Ingestion: Do not induce vomiting, rinse mouth with water, ensure rapid transport to medical facility for assessment and treatment
General Advice: Trained personnel should handle incidents, facilities equipped for emergency decontamination should respond swiftly
Suitable Extinguishing Media: Use water spray, foam, dry chemical powder, or carbon dioxide
Specific Hazards: Decomposes to emit toxic fumes, including hydrogen chloride and platinum oxides
Protective Equipment: Fire-fighters must use self-contained breathing apparatus, full protective gear
Special Procedures: Keep containers cool with water spray, avoid inhalation of combustion gases
Personal Precautions: Avoid any direct contact, isolate area, ventilate when safe
Environmental Precautions: Prevent entry into drains, surface and ground waters; collect spillage with care and contain for proper disposal
Containment and Cleaning: Wear double gloves, safety goggles, protective clothing, use absorbent material like vermiculite, store cleanup residues in secure and clearly labeled chemical waste containers, clean area thoroughly
Handling: Practice strict laboratory safety procedures, ensure effective local ventilation, work inside chemical fume hood, wash hands and exposed skin thoroughly after handling, avoid eating, smoking, or drinking in work area
Storage: Store in tightly sealed, corrosion-resistant containers, protect from light and excessive temperature variation, keep in secure chemical storeroom with access limited to trained personnel, segregate from incompatible substances especially strong acids, bases, and oxidizing agents
Engineering Controls: Operate in ventilated cabinet, employ closed handling systems for bulk transfers, utilize local exhaust
Personal Protective Equipment: Wear laboratory-grade nitrile or double gloves, impermeable lab coats or coveralls, chemical splash goggles, use face shields when risk of splashing, employ respiratory protection equipped with P100 or similar filters for dust or aerosol exposures
Hygiene: Clean thoroughly before breaks and after shifts, ensure containment of contaminated items before laundry or disposal
Occupational Exposure Limits: Follow country-specific occupational health guidelines for platinum compounds
Appearance: Yellow-orange crystalline powder
Odor: No distinctive odor
pH: Neutral aqueous solutions
Solubility: Sparingly soluble in water (2.53 mg/mL at 25°C), slightly soluble in alcohol, insoluble in ether
Boiling Point: Decomposes without boiling
Melting Point: 270°C (with decomposition)
Density: 3.7 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Not applicable or available
Stability in Solution: Stable under normal laboratory conditions if protected from light
Chemical Stability: Remains stable under recommended storage and handling settings
Possible Reactions: Incompatible with strong acids, bases, oxidizing agents; hazardous reactions possible from contact with certain chemicals
Decomposition: Thermal decomposition releases toxic gases such as hydrogen chloride and platinum oxides, prolonged exposure to light or heat can degrade compound
Polymerization: Not anticipated under normal conditions
Acute Toxicity: Very toxic by intravenous, intraperitoneal, and inhalational routes; causes severe irritation of eyes, skin, and mucous membranes
Chronic Effects: Documented carcinogen, mutagenic and teratogenic potential
Target Organ Toxicity: Nephrotoxicity (kidneys), ototoxicity (hearing), neurotoxicity (peripheral nerves), myelosuppression (bone marrow)
Sensitization: May trigger allergic reactions, particularly skin sensitization, and asthma-like symptoms through inhalation
Human Data: Occupational exposure linked with increased cancer risks and organ damage
Aquatic Toxicity: Highly toxic to aquatic organisms, risk of long-term adverse effects in aquatic environments
Persistence and Degradability: Resilient in the environment, limited biodegradation observed
Bioaccumulation Potential: Platinum compounds can accumulate in aquatic biota
Mobility in Soil: Cisplatin binds to particulate soil matter, may persist in sediment
Additional Data: Release into environment should be strictly controlled given potential impact on ecosystems
Waste Disposal: Treat this material as hazardous chemical waste, incinerate in certified facility only, do not dispose with regular municipal waste
Container Disposal: Decontaminate and destroy or dispose of according to specialized procedures, avoid reuse of any packaging
Precautions: Follow national and local regulations, consult licensed hazardous waste contractor, document disposal fully
UN Number: UN 2811
Proper Shipping Name: Toxic Solids, Organic, n.o.s. (Contains Cisplatin)
Transport Hazard Class: Class 6.1 (Toxic substances)
Packing Group: II
Special Precautions: Label clearly with hazard warnings, secure packaging, restrict access throughout transport, provide emergency protocols to handlers and carriers
Environmental Hazards: Mark as dangerous for the environment due to aquatic toxicity
Transport Regulations: Adhere to IATA, IMDG, DOT, and regional guidance
OSHA: Regulated hazardous substance
IARC Classification: Group 2A (probably carcinogenic to humans)
SARA Title III: Refer to reporting requirements for toxic materials
TSCA: Listed or exempt under applicable chemical inventories
European Union: Classified as carcinogenic, toxic, and sensitizing under CLP regulation
Country-Specific Registration: Subject to varying restrictions and reporting depending on use, registration, and occupational exposure levels
Other Regulations: Follow all national, local, and institutional safety regulations pertaining to cytotoxic agents
