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Product Name: Cimetidine-Ab Type
Chemical Name: 4-[2-(Diethylamino)ethyl]-2-[(5-methyl-1H-imidazol-4-yl)methylthio]pyrimidine
Synonyms: Cimetidine, Tagamet
Manufacturer: [Company details]
Recommended Use: Pharmaceutical ingredient (histamine H2 receptor antagonist)
Emergency Contact: [Phone and manufacturer contact information]
CAS Number: 51481-61-9
Classification: Not classified as hazardous according to OSHA/GHS criteria for pharmaceutical actives; risk exists with prolonged, repeated, or high-volume exposure
Health Hazards: May cause mild eye, skin, and respiratory irritation; ingestion of substantial amounts could impact gastrointestinal system
Label Elements: No pictograms required, but cautionary statements recommend minimization of direct exposure
Signal Word: None required
Precautionary Statements: Wash hands thoroughly after handling; avoid breathing dust or powder; use only with proper ventilation
Cimetidine: 98-100%
Excipient/Inactive Ingredients: May contain minor proprietary binders or flow agents, each present at less than 2%
Impurities: Trace process impurities may be present under regulatory thresholds
Eye Contact: Rinse immediately under running water for at least 15 minutes; remove contact lenses if present
Skin Contact: Wash with soap and plenty of water; remove contaminated clothing and launder before reuse
Inhalation: Move to fresh air; seek medical support if symptoms like coughing or shortness of breath persist
Ingestion: Rinse mouth, drink water if able, do not induce vomiting unless medical personnel advise; obtain medical attention for large or symptomatic exposures
Symptoms to Watch: Redness, burning, nausea, headache in cases of overexposure
Flammability: Cimetidine-Ab is not classified as flammable or combustible
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam according to surroundings
Special Hazards: Combustion can release toxic, irritating fumes, including nitrogen oxides, sulfur oxides, and carbon oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and protective clothing
Further Information: Product is stable; packaging can be combustible
Personal Precautions: Wear gloves, goggles, and, if dust is generated, an NIOSH-approved dust mask
Environmental Precautions: Prevent spillage from entering drains, surface water, or soil
Cleanup Methods: Sweep up spilled powder using a HEPA-filtered vacuum or damp methods; avoid dry sweeping that disperses dust; place material in closed container for disposal
Decontamination: Wash area with water and detergent after pickup
Handling: Use in ventilated areas, minimize dust generation, avoid contact with eyes and skin; wear appropriate protection
Storage Conditions: Store in tightly closed original container, away from direct sunlight, moisture, and incompatible substances such as strong acids or oxidizers
Temperature Requirements: Keep at controlled room temperature (15–25°C); protect from freezing
Other Precautions: Restrict access to trained personnel only; maintain clear labeling on all containers
Engineering Controls: Local exhaust recommended; process in containment if possible to minimize airborne exposure
Personal Protective Equipment:
Gloves: Nitrile or PVC, chemical-resistant.
Eye Protection: Chemical safety goggles.
Respirators: N95 or equivalent mask in case of dust or powder.
Workplace Hygiene: Wash hands and exposed skin after handling; do not eat, drink, or smoke while handling the product
Exposure Guidelines: Occupational exposure limits for cimetidine not established; use workplace best practices
Appearance: White to off-white crystalline powder, odorless
Melting Point: 140–146°C
Solubility: Soluble in water, methanol, slightly soluble in ethanol
pH (1% Solution): Approx. 6–8
Vapor Pressure: Not volatile at ambient temperature
Density: Approx. 1.1 g/cm³
Flash Point: Not applicable
Auto-ignition Temperature: Not available
Partition Coefficient (Log P): 0.4–0.5
Chemical Stability: Stable under normal storage and handling conditions
Hazardous Reactions: No dangerous reactions known in normal conditions
Incompatible Materials: Strong oxidizing agents, acids
Decomposition Products: Thermal decomposition releases nitrogen oxides, sulfur oxides, carbon monoxide, and carbon dioxide
Polymerization: Product does not polymerize
Relevant Routes of Exposure: Eye contact, skin contact, inhalation, ingestion
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg; not acutely toxic in small pharmaceutical doses
Chronic Effects: Long-term exposure above recommended levels may impact liver and gastrointestinal systems
Sensitization: Rarely observed
Carcinogenicity: Not classified as carcinogen; IARC, NTP, and OSHA do not list cimetidine
Mutagenicity and Reproductive Toxicity: Genotoxicity not significant in animal studies; reproductive effects not noted at therapeutic doses
Other Health Effects: Potential for mild headache, dizziness, mild gastrointestinal upset if exposed in large quantities
Aquatic Toxicity: Limited data; no acute hazard identified for aquatic life at low concentrations
Mobility: Moderate in soil; soluble in water, can reach surface water if released
Persistence and Degradability: Expected to be biodegradable with time; breakdown to simpler compounds
Bioaccumulation: Low potential due to pharmacokinetic properties
Other Adverse Effects: Use good practices to avoid release in the environment; avoid discharge into drains or watercourses
Waste Treatment Methods: Dispose in accordance with local, regional, national, and international regulations
Product Disposal: Treat as pharmaceutical waste; incinerate in permitted facility where possible; do not discharge to sewer
Container Disposal: Triple rinse or clean containers; dispose as required for hazardous chemical packaging
Spillage Disposal: Absorb with inert material, transfer to labeled container for disposal
UN Number: Not regulated for transport
ADR/RID/IMDG/IATA Classification: Not classified as hazardous for transport
Proper Shipping Name: Not restricted
Packing Group: Not assigned
Special Precautions: Secure containers in transport, protect from extreme heat or cold; conform to national and carrier-specific requirements
OSHA Status: Not classified as hazardous
TSCA Status: Exempt as pharmaceutical active ingredient
SARA Title III: Does not contain components subject to reporting requirements
REACH Registration: Substance appropriately registered or exempt under pharmaceutical regulatory status
Other Regulatory Status: Subject to regulations applicable to manufacturing, handling, and disposal in pharmaceutical environments; users must comply with current national and local rules
