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Product Name: Cilostazol
Chemical Formula: C20H27N5O2
Other Names: 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
CAS Number: 73963-72-1
Molecular Weight: 369.46 g/mol
Manufacturer: Refer to supplier information label
Recommended Use: Pharmaceutical agent
Restrictions on Use: For professional use only; not for personal or household use
GHS Classification: Not classified as hazardous
Signal Word: None
Pictograms: None
Hazard Phrases: May cause irritation to eyes, skin, and respiratory tract upon prolonged exposure; harmful if swallowed in large amounts; has not been shown to pose significant hazard in small quantities typically encountered in lab or pharmacy settings
Precautionary Statements: Avoid breathing dust; wash exposed skin thoroughly after handling; wear appropriate gloves and eye protection; do not eat or smoke when handling the compound
Exposure Routes: Inhalation, skin contact, ingestion
Cilostazol: 98% or higher
Synonyms: Pletal
Impurities: May include trace synthetic byproducts, less than 2%
Additives or Excipients: Not applicable in pure substance
Inhalation: Move person to fresh air; monitor for difficulty in breathing; consult physician if symptoms persist
Skin Contact: Remove contaminated clothing; rinse skin with soap and water; get medical attention for persistent irritation
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical help if irritation occurs
Ingestion: Rinse mouth with water; seek immediate medical advice; never give anything by mouth to an unconscious person
Most Important Symptoms: Irritation of skin, eyes, respiratory tract; headache, nausea in case of significant ingestion
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: Emits toxic fumes under fire conditions; combustion may release nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Wear self-contained breathing apparatus and full protective gear when fighting fires
Firefighting Procedures: Use water spray to cool unopened containers; avoid breathing smoke or fumes
Personal Precautions: Evacuate unnecessary personnel; provide adequate ventilation; avoid dust production
Environmental Precautions: Prevent further leakage or spillage; do not allow product to reach drains or water sources
Cleaning Methods: Wear appropriate PPE including respiratory protection; use inert absorbent material to collect spilled powder; wash area thoroughly after cleanup; dispose of waste in accordance with regulations
Handling: Avoid contact with eyes, skin, and clothing; prevent dust formation; use with local exhaust ventilation; wash after handling
Storage: Keep in well-closed, clearly labeled container; store in a dry, cool, ventilated place; protect from light; segregate from food, beverages, and incompatible substances; keep away from oxidizers
Incompatible Materials: Strong oxidizing agents, strong acids
Engineering Controls: Work in fume hood or with adequate local exhaust ventilation
Eyes: Safety goggles
Skin: Impermeable gloves, lab coat
Respiratory: Use dust mask or respirator if ventilation insufficient, especially during powder handling
Workplace Exposure Limits: Not established for Cilostazol; follow general pharmaceutical handling guidelines
Hygiene Measures: No eating, drinking, or smoking in work area; wash hands before breaks and after handling
Appearance: White to off-white powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not applicable (insoluble in water)
Melting Point: 159–160 °C
Boiling Point: Not available; decomposes
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Not considered flammable in solid form
Explosive Limits: Not determined
Vapor Pressure: Negligible at ambient temperature
Solubility: Slightly soluble in water; freely soluble in acetone, methanol, ethanol
Partition Coefficient (logP): 3.5 (approximate)
Decomposition Temperature: Not specified; decomposes at higher temperatures
Viscosity: Not applicable
Chemical Stability: Stable under standard storage and handling conditions
Reactivity: No dangerous reactions under normal conditions
Controls: Avoid exposure to extreme heat, strong acids, oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg (literature)
Skin Irritation: May cause mild irritation
Eye Irritation: May cause irritation
Inhalation: May irritate respiratory tract if dust is inhaled
Chronic Exposure: No known chronic effects in humans at occupational levels; long-term high use may cause headache, gastrointestinal upset as reported in pharmaceutical trials
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No evidence of mutagenic potential in standard tests
Reproductive Toxicity: No evidence of effects at occupational exposure levels
Ecotoxicity: Not expected to be toxic to aquatic life at standard concentrations; limited data available
Persistence and Degradability: Not readily biodegradable
Bioaccumulative Potential: Low, based on chemical structure
Mobility in Soil: Likely low due to minimal water solubility
Other Adverse Effects: Avoid release to the environment; pharmaceutical substances may have effects on aquatic organisms with prolonged exposure
Waste Treatment Methods: Dispose of as pharmaceutical waste in accordance with local and national regulations
Contaminated Packaging: Triple rinse and dispose of as hazardous waste
Environmental Precautions: Do not discharge into drains or waterways; incinerate under controlled conditions where permitted
UN Number: Not regulated as dangerous for transport
DOT/ADR/RID/IMDG/IATA: Not classified as a hazardous material
Proper Shipping Name: Cilostazol
Packing Group: Not assigned
Special Precautions: Protect from physical damage and moisture during transport; ship according to standard procedures for pharmaceutical compounds
TSCA Status: Not listed
OSHA: Not classified as hazardous under OSHA Hazard Communication Standard
DSL/NDSL (Canada): Not listed
EU Regulation: Not classified under Regulation (EC) No 1272/2008 (CLP)
Other Information: Use subject to prescription control by health authorities; handle according to Good Laboratory Practices (GLP) and occupational safety guidelines
