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Product Name: Cidofovir Dihydrate
Synonyms: (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine hydrate
Chemical Family: Nucleotide analog, antiviral agent
CAS Number: 113852-37-2
Manufacturer: Consult supplier for specific details
Use: Research, prescription antiviral medication
GHS Classification: Acute toxicity (Oral, Dermal, Inhalation) Category 4, Eye irritation Category 2A, Reproductive toxicity Category 2, Specific target organ toxicity (single exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may damage fertility or the unborn child, may cause respiratory irritation
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use only outdoors or in a well-ventilated area, wear protective gloves, eye protection, face protection
Cidofovir Dihydrate: 99%
Other Components: Water to hydrate form, residual manufacturing reagents at non-hazardous trace levels
Inhalation: Remove from exposure, move to fresh air, seek medical attention if symptoms occur
Skin Contact: Immediately wash with plenty of soap and water, remove contaminated clothing, seek medical advice if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and seek medical attention
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Symptoms & Effects: May cause eye, skin, respiratory irritation, potential adverse effects on fertility and the unborn child
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical
Specific Hazards: Combustion may produce toxic fumes such as carbon monoxide, nitrogen oxides, phosphorus oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus, protective clothing
Special Procedures: Avoid inhalation of contaminated smoke, contain run-off
Personal Precautions: Evacuate unnecessary personnel, use personal protective equipment, avoid dust formation
Environmental Precautions: Prevent further spillage, avoid discharge to drains, watercourses, soil
Methods for Cleanup: Carefully sweep up, avoid raising dust, transfer to a labeled container for disposal following local regulations, ventilate the area, wash spill site after material pickup is complete
Safe Handling: Work in well-ventilated areas, minimize dust generation and accumulation, use local exhaust ventilation, avoid contact with skin and eyes, handle using protective equipment
Storage Conditions: Store tightly closed in a dry, cool, well-ventilated place, protect from light and incompatible materials such as oxidizers, maintain temperature 2°C-8°C
Special Requirements: Store away from food, drink, animal feed; label clearly and restrict access to trained personnel
Occupational Exposure Limits: No specific national limits set; minimize exposure
Engineering Controls: Work in chemical fume hood or use equivalent containment
Personal Protective Equipment: Impermeable gloves (nitrile or latex), splash goggles, lab coat or apron, suitable respiratory protection for dust or high concentrations
Hygiene Measures: Wash hands after handling, avoid eating, drinking, or smoking during use, regularly clean equipment and work surfaces
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH (solution): Neutral to slightly acidic
Melting Point/Freezing Point: Decomposes above 205°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not considered flammable
Vapor Pressure: Negligible
Vapor Density: Not applicable
Solubility: Freely soluble in water, very slightly soluble in ethanol
Partition Coefficient (n-octanol/water): -0.68 (logP)
Decomposition Temperature: Above 205°C
Viscosity: Not applicable
Molecular Formula: C8H14N3O6P·2H2O
Molecular Weight: 315.22 g/mol (anhydrous base)
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Low under anticipated use and storage
Hazardous Reactions: Not expected under recommended conditions
Incompatible Materials: Strong oxidizers, acids, bases
Decomposition Products: Emits toxic fumes under fire conditions (carbon monoxide, carbon dioxide, nitrogen oxides, phosphorus oxides)
Routes of Entry: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Harmful if swallowed, causes eye irritation, irritates respiratory tract at high dust levels
Chronic Effects: Animal studies show effects on kidneys, reproductive system, possible carcinogenicity has not been fully evaluated for humans
Sensitization: Not classified as sensitizer, rare allergic reactions reported
LD50 (Oral, Rat): 350 mg/kg
Mutagenicity: Evidence shows mutagenic effects in some in vitro systems
Carcinogenicity: No IARC, NTP, or OSHA classification
Reproductive Toxicity: Evidence for developmental risk; avoid exposure in pregnancy
Target Organs: Kidney, reproductive organs
Ecotoxicity: Data limited, potential risk for aquatic organisms, do not discharge into waterways or soil
Persistence and Degradability: Low biodegradability, substance is persistent in the environment
Bioaccumulative Potential: Not considered to have significant bioaccumulation potential
Mobility in Soil: Expected to have moderate mobility
Other Adverse Effects: Prevent uncontrolled entry into environment, healthcare facilities should dispose according to regulations
Waste Disposal: Dispose as pharmaceutical waste according to local, state, and federal regulations
Container Disposal: Triple rinse containers, dispose as hazardous chemical waste
Special Precautions: Avoid disposing in regular household waste, avoid dispersing in the environment, incinerate contents under controlled conditions if permitted
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: Does not meet criteria for hazardous material
Packing Group: Not assigned
Environmental Hazards: Avoid environmental contamination, not a marine pollutant
Special Precautions for User: Use containers that prevent dust dispersal, ensure full documentation for laboratory or commercial shipments
Safety, Health, Environmental Regulations: Subject to workplace chemical safety guidelines; not listed as a controlled substance; check with local health and safety regulations
OSHA Status: Not specifically regulated, follow general chemical safety requirements
TSCA Status: Research uses only, not listed on the TSCA inventory
SARA Title III: Not subject to reporting under Sections 302, 304, 313
REACH Registration: Research or medical use exemption in the EU
Other Standards: Must follow institutional pharmaceutical handling policies, ensure compliance with national and international regulations for controlled pharmaceuticals
