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Product Name: Ciclesonide
Chemical Name: Ciclesonide
Synonyms: Alvesco, Omnaris, Zetonna
Recommended Use: Pharmaceutical corticosteroid; anti-inflammatory agent for respiratory administration
Manufacturer: Refer to supplier labels or the pharmacy distributor
Emergency Contact Information: Refer to local poison control center or medical emergency provider
CAS Number: 126544-47-6
UN Number: Not regulated under UN transport classification
EC Number: Not classified
Molecular Formula: C32H44O7
Molecular Weight: 540.69 g/mol
GHS Classification: Not classified as hazardous under GHS criteria
Main Health Hazards: May cause allergic skin reactions; respiratory irritation possible through prolonged exposure
Environmental Hazards: May cause adverse effects in aquatic environments
Signal Word: None required under GHS
Pictogram: None required
Hazard Statements: May cause skin and eye irritation; can exacerbate respiratory problems with chronic exposure
Precautionary Statements: Avoid contact with eyes, skin, and clothing; wash hands thoroughly after handling
NFPA Ratings: Health 2, Flammability 0, Reactivity 0
Main Ingredient: Ciclesonide
Concentration: ≥98% in pure form; solution or suspension form varies
Impurities: Trace solvent residues from manufacturing; detailed composition listed on pharmaceutical documentation
Other Components: In pharmaceutical product, may contain carrier gases or solvents (e.g., ethanol, propellants)
CAS Number for Other Ingredients: See product documentation for excipients
Inhalation: If breathed in, move to fresh air and monitor breathing; seek medical attention for any shortness of breath or persistent discomfort
Skin Contact: Remove contaminated clothing; wash exposed skin thoroughly with soap and water; medical attention if irritation develops
Eye Contact: Rinse with plenty of water for at least 15 minutes lifting upper and lower eyelids; remove contact lenses; medical aid for persistent symptoms
Ingestion: Rinse mouth; do not induce vomiting; seek medical advice if any discomfort occurs
Most Important Symptoms: Skin or respiratory irritation, allergic reactions
Medical Attention Note: Treat symptomatically and supportively; inform physician of material type
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or foam
Unsuitable Extinguishing Media: None specified; product does not support combustion
Specific Hazards: May emit toxic fumes of carbon oxides upon combustion
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Firefighting Instructions: Isolate area; prevent runoff into waterways; cool containers with water spray
Thermal Decomposition Products: Carbon monoxide, carbon dioxide, and other unidentified decomposition products
Personal Precautions: Wear chemical-resistant gloves, safety goggles, and suitable protective clothing; avoid inhalation of dust or aerosol
Environmental Precautions: Prevent further leakage or spillage if safe; avoid entry into sewers and waterways
Cleanup Methods: Absorb with inert dry material such as sand or vermiculite; gather into a container for proper disposal; ventilate area; wash spill site after material pickup
Notification Procedures: Follow local regulations for reporting spills of pharmaceutical agents
Handling Practices: Use in well-ventilated areas; avoid generating dust or aerosol; prevent direct contact with eyes, skin, and clothing; keep out of reach of unauthorized personnel
Storage Conditions: Store tightly closed in original container; keep in a cool, dry place away from direct sunlight and incompatible substances
Incompatible Materials: Strong oxidizing agents
Other Advice: Limit access to trained operators handling bulk quantities; keep records of quantity held and date of receipt
Exposure Limits: No occupational exposure limits established specifically for Ciclesonide
Engineering Controls: Work under local exhaust ventilation or fume hood
Personal Protective Equipment (PPE): Chemical-resistant gloves, lab coat, safety goggles, dust mask or respirator if handling in powder or aerosol form
General Hygiene Measures: Do not eat, drink, or smoke during handling; wash hands before breaks and after work
Environmental Exposure Controls: Use closed systems or proper venting to minimize environmental release
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: 100–104°C
Boiling Point: Not available
Flash Point: Not flammable
Flammability: Not considered flammable or explosive
Vapor Pressure: Negligible
Solubility: Practically insoluble in water; soluble in some organic solvents such as ethanol
Partition Coefficient: Log P = 4.1 (octanol/water)
Density: Not determined
Stability in Solution: Stable under recommended storage conditions
Evaporation Rate: Not determined
Chemical Stability: Stable under standard temperatures and pressures
Possible Hazardous Reactions: No known hazardous polymerization expected
Conditions to Avoid: Prolonged exposure to heat, moisture, and light
Incompatible Materials: Strong oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly unidentified toxic and/or irritating compounds
Storage Life: Follow expiration dates provided from supplier or manufacturer label
Acute Toxicity: Data limited; in animal studies, oral LD50 >1,000 mg/kg (rat); low acute toxicity expected at therapeutic doses
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Potential Health Effects: Possible skin and eye irritation; respiratory tract discomfort with high doses; allergic reactions for sensitive individuals
Chronic Exposure Risks: Long-term or repeated exposure may have effects on endocrine system by potentiating corticosteroid effects
Carcinogenicity: No classification by IARC, NTP, or OSHA
Reproductive Toxicity: No evidence of reproductive toxicity in available data
Mutagenicity: Not considered mutagenic in standard tests
Sensitization: May cause allergic contact dermatitis
Medical Conditions Aggravated: Individuals with known hypersensitivity to corticosteroids or similar compounds should avoid exposure
Toxicity to Aquatic Organisms: Data not fully established; potential adverse effects for aquatic invertebrates in high concentrations
Persistence and Degradability: Expected to degrade slowly in environment
Bioaccumulative Potential: Log P indicates possible bioaccumulation; actual risk in environmental concentrations not quantified
Mobility in Soil: Limited mobility due to low water solubility
Other Ecological Effects: Avoid release to environment; no data available for effects on plants or terrestrial animals
Disposal Methods: Dispose in accordance with local, regional, or national regulations; do not allow to enter sewers or water systems
Recommended Disposal: Incineration with approved facility is preferred method
Physical/Chemical Disposal Notes: Do not dispose with household garbage; professional waste contractors should handle bulk chemical wastes
Packaging Disposal: Rinse containers before disposal; follow specific container disposal recommendations from supplier
UN Number: Not regulated as a hazardous material under transport regulations
Transport Hazard Class: Not classified
Packing Group: Not applicable
Labels Required: None under standard transport guidelines
Proper Shipping Name: Ciclesonide (pharmaceutical preparation, not regulated)
Special Precautions: Protect against physical damage; ship in moisture-resistant packaging if available
Environmental Hazards during Transport: Avoid release into environment
OSHA: Not listed as hazardous
TSCA Inventory: Not listed; used for pharmaceutical applications only
REACH Status: Not relevant; medication not intended for general industrial use
SARA Title III: Not subject to reporting requirements
DSL/NDSL (Canada): Not listed
WHMIS Classification: Exempt for pharmaceutical product
Other Regulations: Prescription-only medicine; possession and supply controlled by regulatory agency for pharmaceuticals in each jurisdiction
Risk Phrases: Not classified as hazardous; precautionary statements applicable to industrial handling of bulk material
SDS Availability: SDS available from pharmaceutical suppliers and upon request for bulk shipments
