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Product Name: Chlorpropamide
Chemical Name: p-(Chlorosulfonyl)benzamide
Synonyms: Diabinese, 4-Chlorobenzenesulfonamide-1-propyl-1-urea
Chemical Formula: C10H13ClN2O3S
Molecular Weight: 276.74 g/mol
CAS Number: 94-20-2
Intended Use: Pharmaceutical, oral hypoglycemic agent
Manufacturer: Refer to product packaging or supplier
Emergency Contact: Refer to local poison control center or emergency services
Classification: Harmful if swallowed
Acute Toxicity: May cause headache, hypoglycemia, weakness
Skin Contact: May provoke mild irritation
Eye Contact: Irritates eyes and mucous membranes
Inhalation: Dust can irritate respiratory tract
Chronic Effects: Repeated exposure may affect the liver and kidneys
Environmental Hazard: Harmful to aquatic life, persists in some environments
Pictograms: Exclamation mark, Health hazard symbol
Main Substance: Chlorpropamide (purity >98%)
Impurities: Trace organic solvents, residual salts, proprietary stabilizers
Other Constituents: No additional hazardous ingredients present above OSHA threshold
Eyes: Rinse eyes with cool running water for 15 minutes. Remove contact lenses if present, continue rinsing. Seek medical help if irritation persists.
Skin: Wash with soap and water. Take off contaminated clothing. Seek medical attention if irritation develops.
Inhalation: Move person to fresh air. Loosen tight clothing, keep at rest. Medical attention required if symptoms like dizziness or nausea show.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly. Drink water only if person is conscious. Get immediate medical advice.
General Advice: Call poison control or healthcare professional for further guidance.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, or water spray
Hazards from Combustion: Emits HCl, SOx, CO, and nitrogen oxides
Protective Equipment: Full protective gear including self-contained breathing apparatus
Specific Hazards: Toxic, corrosive fumes, potential for thermal decomposition products
Hazardous Combustion Products: Chlorinated compounds and sulfur oxides may evolve
Personal Precautions: Wear gloves, safety goggles, and a lab coat. Avoid inhalation and contact with skin.
Environmental Precautions: Prevent runoff into drains, waterways, or soil
Spill Cleanup: Sweep up without creating dust. Place in properly labeled waste containers. Dispose according to local regulations.
Decontamination: Wipe area with damp disposable cloth; avoid splashing
Additional Advice: Wash exposed skin after handling. Ventilate area thoroughly.
Handling: Work in well-ventilated area. Avoid contact with skin and eyes. Use appropriate safety equipment.
Storage: Store in keep tightly closed, original containers in a cool, dry, well-ventilated space. Avoid exposure to sunlight and moisture.
Specific Storage Conditions: Do not store with oxidants or acids. Keep away from food, beverages, and animal feed.
Incompatibilities: Oxidizers, strong acids, alkalis.
Hygiene Measures: Wash hands thoroughly after handling. No eating, drinking, or smoking in work area.
Engineering Controls: Use with adequate ventilation, fume hood preferred; maintain exhaust systems.
Occupational Exposure Limit: Not established for chlorpropamide; observe limits for nuisance dust (10 mg/m³).
Respiratory Protection: Use NIOSH-approved dust mask for airborne particles.
Hand Protection: Nitrile or latex gloves recommended.
Eye Protection: Chemical splash goggles or safety glasses.
Skin Protection: Lab coat or aprons, closed shoes.
Environmental Controls: Prevent release into public sewers or water systems.
Appearance: white to off-white crystalline powder
Odor: Odorless or faint, not easily detectable
pH (solution, 1%): Nearly neutral (6-8)
Melting Point: 188 - 192 °C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water; soluble in alcohols and organic solvents
Partition Coefficient (log Kow): Approx. 0.7
Vapor Pressure: Negligible at ambient conditions
Density: 1.38 g/cm³
Flash Point: No data, expected to be nonflammable
Evaporation Rate: Not applicable
Auto-Ignition Temp: Not available
Decomposition Temp: Decomposes above 200 °C, emitting toxic gases
Chemical Stability: Stable under recommended storage, light and moisture may deteriorate quality
Reactivity: Reacts with oxidants, acids, and alkali materials
Hazardous Decomposition: Produces HCl, SO2, CO, NOx upon decomposition
Conditions To Avoid: Heat, flames, incompatibles, prolonged face-to-air exposure
Polymerization: Not known to occur under normal conditions
Acute Toxicity: Oral LD50 (rat): 630 mg/kg
Inhalation: May irritate airways, cause coughing
Skin Contact: Not a primary irritant. Possible mild reaction with prolonged exposure.
Eye Contact: Moderate irritant in animal models; data in humans limited
Chronic Exposure: Risk of hypoglycemia, liver, and kidney effects with chronic pharmaceutical use
Carcinogenicity: Not classified as carcinogenic (IARC, NTP, OSHA)
Mutagenicity: Not mutagenic in standard test systems
Sensitization: Rare, but reports exist of allergic skin response
Reproductive Risk: Data do not show direct reproductive toxicity
Aquatic Toxicity: Moderate toxicity to aquatic organisms
Persistence: Biodegradability limited, can persist in some environments
Bioaccumulation: Expected to have low potential due to water solubility
Mobility: May migrate with water in soil, low volatility limits air contamination
Impact: Avoid bulk release into environment; can disrupt local wastewater treatment bacteria
Further Information: No major ecosystem biohazards reported, but long-term effects not entirely known
Waste Disposal: Dispose as hazardous waste. Use professional waste contractor approved for pharmaceuticals
Contaminated Containers: Rinse, triple-wash, destroy to avoid reuse.
Sewage Disposal: Do not pour into drains or watercourses.
Disposal Methods: Incinerate in licensed facility, following local and national regulations
Additional Instructions: Document disposal procedures for compliance audits
UN Number: Not assigned
UN Proper Shipping Name: Not a regulated substance under major international conventions
Transport Hazard Class: Not classified as hazardous material for transport
Packing Group: Not applicable
Special Precautions: Ship as pharmaceutical chemical. Keep sealed, avoid crushing. Follow personal safety, local packaging regulations.
Marine Pollutant: Not identified as marine pollutant
OSHA Regulation: Not classified as hazardous under US OSHA Hazard Communication Standard
TSCA Status: Listed
WHMIS Classification (Canada): Not controlled
EU Classification: Not dangerous per Directive 67/548/EEC
REACH Status: Subject to pre-registration; no substance of very high concern
Other Regulation: Drug active ingredient regulated by FDA, EMA, and other authorities; subject to transport and disposal controls specific to pharmaceuticals
Labeling Requirements: Product identifier, hazard pictograms, risk and safety statements
Additional National / Regional Regulations: Local authorities may require additional registration, handling documentation, and safe use instructions
