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Product Name: Chlorpromazine Hydrochloride
Chemical Name: 2-chloro-10-(3-dimethylaminopropyl)phenothiazine monohydrochloride
CAS Number: 69-09-0
Molecular Formula: C17H19ClN2S·HCl
Relevant Identified Uses: Pharmaceutical ingredient, antipsychotic agent
Manufacturer/Supplier: Large-scale pharmaceutical and chemical supply companies
Contact Information: Found on packaging and regulatory documents supplied by manufacturer
GHS Classification: Acute toxicity (oral), Category 4; Skin irritation, Category 2; Serious eye irritation, Category 2A; Specific target organ toxicity (repeated exposure), Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Wash hands thoroughly after handling, avoid breathing dust, wear protective gloves/eye protection/face protection
Chemical: Chlorpromazine Hydrochloride
CAS Number: 69-09-0
EC Number: 200-684-5
Content: Typically 98% and above purity for pharmaceutical and laboratory use
Other Ingredients: None relevant for identification at effective concentration
Inhalation: Move to fresh air, monitor breathing, seek medical attention if symptoms appear
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, consult a physician if irritation occurs
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical attention immediately
Ingestion: Rinse mouth, seek medical attention promptly, do not induce vomiting without advice from medical staff
Symptoms: Nausea, vomiting, drowsiness, skin and eye irritation, agitation, muscle tremors
Suitable Extinguishing Media: Water spray, alcohol resistant foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: High-pressure water streams can spread dust
Specific Hazards: Toxic fumes such as hydrogen chloride, nitrogen oxides, sulfur oxides can develop under fire conditions
Special Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Personal Precautions: Wear personal protective equipment including gloves and safety goggles, avoid breathing dust, ventilate area
Environmental Precautions: Prevent further leakage or spillage, avoid release into the environment, keep material out of waterways
Cleanup Methods: Sweep up using non-sparking tools, place in a suitable, closed container for disposal, clean area with plenty of water
Handling: Avoid contact with skin, eyes, and clothing. Minimize dust generation and accumulation. Use only in a well-ventilated area
Storage Conditions: Keep container tightly closed in a cool, dry, and well-ventilated place, away from incompatible substances such as strong oxidizers
Incompatible Materials: Strong acids, bases, oxidizing agents
Other Precautions: Prevent static discharge, use proper grounding procedures if handling bulk quantities
Control Parameters: Occupational exposure limits currently not established in many jurisdictions, but handle as potentially hazardous
Engineering Controls: Use process enclosures or local exhaust ventilation to maintain airborne levels below recommended exposures
Personal Protection: Wear protective gloves, laboratory coat or apron, chemical safety goggles, approved respirator if ventilation is inadequate
Hygiene Measures: Wash hands thoroughly after handling, avoid eating, drinking, or smoking in work areas
Appearance: White or slightly yellow crystalline powder
Odor: Odorless or faint medicinal smell
Melting Point: 193-198°C (decomposes)
Solubility: Freely soluble in water, slightly soluble in alcohol
pH (1% Solution): Ranges from 3.5 to 5.5
Boiling Point: Not applicable (decomposes before boiling)
Flashpoint: Not established
Vapor Pressure: Negligible
Molecular Weight: 355.33 g/mol
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizing agents; avoid prolonged exposure to light and air
Conditions to Avoid: Heat, direct sunlight, moisture
Decomposition Products: May release toxic fumes including nitrogen oxides, sulfur oxides, hydrogen chloride on decomposition
Polymerization: Hazardous polymerization will not occur
Acute Toxicity: Oral LD50 (rat) ~ 317 mg/kg; can cause confusion, hypotension, drowsiness at toxic doses
Skin Corrosion/Irritation: Prolonged contact can lead to mild irritation
Serious Eye Damage/Irritation: Contact causes moderate to severe irritation
Respiratory Sensitization: May cause respiratory tract irritation if inhaled
Other Effects: Prolonged exposure has been linked to liver and nervous system effects, movement disorders, and changes in blood count. Not classified as carcinogenic by IARC
Ecotoxicity: Toxic to aquatic life with long-lasting effects; specific data for aquatic organisms show inhibition and possible disruption to ecosystem balance
Persistence and Degradability: Limited biodegradation in typical wastewater treatment; persists if released to environment
Bioaccumulation: Low bioaccumulation potential based on chemical structure
Mobility in Soil: Water soluble, mobile in aquatic systems, may enter watercourses if released in quantity
Other Adverse Effects: Take care to avoid disposal or release into the environment to limit cumulative impact
Product Disposal: Dispose of surplus and contaminated material as hazardous chemical waste in compliance with local, state, and federal regulations
Container Disposal: Rinse and dispose of containers in accordance with environmental authority guidelines
Other Notes: Do not dispose of via drains, avoid environmental release, consider incineration in authorized facility if permitted
UN Number: Not classified as dangerous for transport in small quantities
Proper Shipping Name: Chlorpromazine Hydrochloride
Transport Hazard Class: Not assigned for small or standard pharmaceutical amounts
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant when shipped in limited quantities
Special Precautions: Avoid moisture exposure during transport, avoid direct sunlight or temperature extremes
Inventory Listings: Listed on United States TSCA, European EINECS, and other major chemical inventories
OSHA Status: Regulated as hazardous under OSHA Hazard Communication Standard
SARA Title III: Not specifically listed, but general hazard applies
WHMIS Classification (Canada): Controlled product; D2B (toxic materials causing other toxic effects)
REACH Status (EU): Registered substance with applicable safety and use guidelines
Other Compliance: Follows requirements set forth under US EPA, Canadian CEPA, European directives on medicinal and laboratory chemicals
