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Material Safety Data Sheet: Cephapirin Sodium

Identification

Product Name: Cephapirin Sodium
Chemical Family: Cephalosporin Antibiotic
SYNONYMS: Cephalexin sodium salt, Cefapirin sodium
CAS Number: 27164-46-1
Recommended Use: Veterinary antibiotic, pharmaceutical agent
Supplier Information: Contact information for distributor or manufacturer listed on shipping documentation
Emergency Contact Number: Listed on shipping label, Poison Control Center available for assistance

Hazard Identification

Hazard Classification: Not classified as hazardous under GHS for general handling, but inhalation, ingestion, or skin exposure may cause allergic reactions in some individuals
Signal Word: Warning
Pictogram: Exclamation mark for sensitization hazard
Hazard Statements: May cause respiratory or skin sensitization, risk of allergic reactions, may cause eye irritation
Precautionary Statements: Avoid inhalation, contact with skin and eyes, use personal protective equipment during handling
Routes of Exposure: Inhalation, skin, eyes, ingestion
Symptoms of Exposure: Itching, rash, redness, respiratory difficulty, possible anaphylactic reaction in hypersensitive persons

Composition / Information on Ingredients

Main Ingredient: Cephapirin Sodium
Chemical Formula: C17H16N3NaO6S2
Concentration: Active pharmaceutical ingredient, typically >95% purity
Additive Ingredients: None unless formulated in specific dosage form
Impurities: Trace amounts of manufacturing impurities (typically <2%) defined by batch quality specification

First Aid Measures

Inhalation: Move to fresh air, seek immediate medical attention if breathing difficulty develops, monitor for signs of allergy
Skin Contact: Immediately wash area with soap and water, remove contaminated clothing, medical attention for persistent irritation or allergic symptoms
Eye Contact: Rinse with plenty of water, hold eyelids open, medical evaluation for redness, pain, or persistent discomfort
Ingestion: Rinse mouth with water, seek prompt medical help, do not induce vomiting unless on advice from medical personnel
Most Important Symptoms: Allergic reactions including hives, difficulty breathing, facial or tongue swelling
Information for Medical Personnel: Treat symptomatically, monitor for signs of anaphylaxis or severe allergic response, provide supportive therapy as necessary

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Special Hazards: Combustion releases carbon oxides, nitrogen oxides, sulfur oxides, sodium oxides, may emit irritating or toxic fumes
Protective Equipment: Self-contained breathing apparatus, protective clothing
Precautions: Remove containers from fire area if safe, prevent runoff to waterways or drains
Explosion Data: Cephapirin Sodium does not have explosive properties but can decompose on heating

Accidental Release Measures

Personal Precautions: Ventilate area, avoid dust formation, use personal protective equipment
Environmental Precautions: Prevent further leakage if safe, avoid discharge into drains, waterways, or soil
Methods for Cleanup: Sweep up and place in a suitable container for disposal, wash spill site with water and detergent, minimize dust generation
Decontamination: Use damp cloth or mop for residual material, dispose of cleaning materials as hazardous waste if contaminated

Handling and Storage

Handling: Wear gloves, lab coat, and eye protection, work in well-ventilated area, avoid breathing dust, wash hands after use
Storage: Store in original container, tightly closed, at room temperature or as advised by manufacturer, protect from moisture and direct sunlight, segregate from incompatible materials
Incompatible Materials: Strong oxidizers, acids, bases, moisture
Handling Precautions: Minimize dust generation, keep away from food and drink, avoid contact with skin and eyes

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established exposure limits, use pharmacological exposure control banding when available
Engineering Controls: Use fume hood or local exhaust ventilation for powder handling
Personal Protective Equipment: Protective gloves, safety goggles, lab coat, NIOSH-approved respirator if ventilation is inadequate
Hygiene Measures: Wash hands thoroughly after handling, prevent cross-contamination, avoid ingestion or inhalation

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Approximately 4.5-7.0 in aqueous solution
Melting Point/Freezing Point: Decomposes before melting
Boiling Point: Not applicable, decomposes
Flash Point: Not applicable
Flammability: Not flammable
Solubility: Soluble in water, practically insoluble in organic solvents
Vapor Pressure: Not relevant for solid material
Partition Coefficient (n-octanol/water): Not determined
Density: 1.6-1.8 g/cm³ (estimate)

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Non-reactive under normal use, avoid exposure to strong oxidizing/reducing agents
Conditions to Avoid: Excess moisture, elevated temperatures, direct sunlight
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, sodium oxide
Polymerization: Will not occur

Toxicological Information

Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: Not acutely toxic by oral or dermal route, but may be irritating
Sensitization: Known to cause allergic reactions in sensitized individuals, potential for severe anaphylactic response
Chronic Toxicity: Long-term exposure not well-studied, chronic effects unlikely under controlled conditions
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No data for teratogenic effects, avoid exposure during pregnancy
Mutagenicity: No definitive mutagenic activity found in standard tests
Symptoms: Allergic skin reactions, respiratory issues, eye irritation, possible headaches or nausea

Ecological Information

Ecotoxicity: May be harmful to aquatic organisms at high concentrations, risk of antibiotic resistance development in water systems
Persistence and Degradability: Moderate degradation in aquatic environments, may persist under certain conditions
Bioaccumulation: Low potential for bioaccumulation
Mobility in Soil: Expected to be somewhat mobile, especially in moist conditions
Additional Effects: No significant hazards reported for terrestrial wildlife, monitor water effluent to minimize pharmaceutical pollution

Disposal Considerations

Waste Disposal Method: Dispose of material as pharmaceutical waste according to local, regional, and national regulations
Container Disposal: Do not reuse empty containers, puncture or crush before disposal, handle as hazardous waste
Sewage Disposal: Do not discharge to municipal sewers or natural water systems
Special Precautions: Consult local hazardous waste disposal service, incinerate under controlled conditions if permitted

Transport Information

Proper Shipping Name: Cephapirin Sodium, not regulated for transport in non-bulk quantities
UN Number: Not allocated
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Transport Precautions: Keep container tightly closed, dry, and protected from physical damage during transport
Special Transport Information: Emergency contact number listed on shipping documents

Regulatory Information

Regulatory Status: Approved for veterinary and pharmaceutical use under specific regulatory conditions
OSHA Hazard Communication: Considered hazardous due to potential for sensitization
WHMIS Classification (Canada): Not specifically controlled, use good laboratory practices
TSCA Status: Exempt as a pharmaceutical product
EU Regulations: Subject to relevant REACH and CLP requirements for pharmaceutical substances
Other Regulatory Listings: Check local and regional requirements for controlled antibiotics and prescription pharmaceuticals