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Product Name: Cefuroxime Sodium
Chemical Formula: C16H15N4NaO8S
Synonyms: Cefuroxime sodium salt, Zinacef
CAS Number: 56238-63-2
Manufacturer: Refer to supplier documentation
Recommended Use: Pharmaceutical intermediate or antibiotic
Emergency Phone: Refer to supplier information
Contact Information: Manufacturer or distributor contact details found on packaging or purchase documentation
GHS Classification: Eye Irritant–Category 2A; Specific Target Organ Toxicity (Single Exposure)–Category 3; Respiratory Sensitizer–Category 1; Skin Sensitizer–Category 1
Label Elements: Warning symbol for respiratory and skin sensitization; exclamation mark for irritation
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause allergy or asthma symptoms or breathing difficulties, may cause allergic skin reaction, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, use protective gear, wash hands after handling, seek medical attention if symptoms develop, use only with proper ventilation
Cefuroxime Sodium: 98-100%
Impurities: Trace byproducts & solvents consistent with manufacturing, negligible by overall weight, not expected to alter physical hazards
Other Ingredients: No significant excipients present
Inhalation: Remove to fresh air, seek immediate medical attention if breathing difficulty develops, give artificial respiration if needed
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, get medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, seek prompt medical care
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, consult poison control or physician at once
Most Important Symptoms: Allergic reactions, shortness of breath, skin rashes, burns, respiratory irritation
Medical Attention and Special Treatment: Treat symptomatically, monitor for respiratory distress, keep available material safety information for physicians
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Do not apply high-pressure water streams directly on chemical
Specific Hazards: Combustion releases toxic fumes of oxides of nitrogen, sulfur, carbon monoxide, carbon dioxide
Protective Equipment: Self-contained breathing apparatus and full protective gear, keep people away from fire and smoke
Advice for Firefighters: Move containers from fire area if safe, prevent fire runoff from entering water supplies or open environments
Personal Precautions: Wear dust mask, suitable gloves, chemical goggles, avoid direct skin and eye contact, ventilate area
Environmental Precautions: Prevent material from entering drains, watercourses, or open soil; report spill to authorities if environmental contamination occurs
Cleanup Procedures: Scoop up spilled product using methods minimizing dust, place in suitable container for disposal, wipe area with damp cloth, ventilate area well after cleanup
Precautions for Safe Handling: Use in chemical fume hood or well-ventilated location, avoid inhalation, prevent contact with skin and eyes, employ proper hygiene measures after use
Conditions for Safe Storage: Store in tightly closed container, keep container in cool, dry location protected from light, segregate from incompatible substances like strong oxidizers, acids, bases
Storage Temperature: Typically between 2°C and 8°C (refrigerated) unless specified otherwise by manufacturer
Incompatibilities: Avoid strong acids, oxidizers, alkalis, moisture
Special Instructions: Clearly label containers, restrict access to trained personnel, monitor temperature and humidity in storage area
Occupational Exposure Limits: No specific governmental exposure limits established, but minimize inhalation and surface contact
Engineering Controls: Employ local exhaust ventilation, safety shower, eye wash stations in work area
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), chemical splash goggles or face shield, lab coat or protective suit, approved respirator if dust concentration is high
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, avoid eating, drinking, or smoking in work areas, dispose of contaminated gear properly
Form: White to off-white crystalline powder
Odor: Faint, characteristic smell, not strong or offensive
Solubility: Readily soluble in water
pH (solution): 6.0 – 8.5 (for standard aqueous solution)
Melting Point: Decomposes at elevated temperatures (>180°C)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable under typical circumstances
Vapor Pressure: Negligible at ambient conditions
Density: Approximately 1.6-1.8 g/cm³
Partition Coefficient (Log Pow): Not determined
Other Data: Sensitive to light and moisture, keep container tightly sealed to avoid degradation
Chemical Stability: Stable under standard storage and handling, degrades upon exposure to light, heat, moisture
Hazardous Reactions: No dangerous reactivity under normal conditions, violent reaction possible with strong oxidizers or reductants
Conditions to Avoid: High heat, open flames, direct sunlight, excess moisture
Incompatible Materials: Strong acids, strong alkalis, oxidizing agents
Hazardous Decomposition Products: Toxic nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide
Routes of Exposure: Inhalation, skin absorption, eye contact, ingestion
Acute Toxicity: LD50 (oral rat) >5,000 mg/kg; low acute oral toxicity in animals
Skin Corrosion/Irritation: Can cause irritation, redness, possible allergic dermatitis
Eye Damage/Irritation: May produce moderate eye irritation, pain, or redness
Respiratory or Skin Sensitization: May trigger asthmatic or allergic response in susceptible individuals
Repeated Dose Toxicity: Systemic effects possible in chronic occupational exposure—respiratory hypersensitivity, kidney or liver impact
Carcinogenicity: No carcinogenic effects observed in animal studies and not listed by IARC, NTP, or OSHA
Mutagenicity: Not classified as mutagenic based on available data
Reproductive Toxicity: No effects observed in standard animal studies
Other Effects: Allergic reactions possible in penicillin-sensitive persons
Aquatic Toxicity: Cefuroxime sodium can affect aquatic organisms due to persistence and presence of antibiotics
Persistence and Degradability: Moderately persistent, not readily biodegradable, bioaccumulation not expected
Bioaccumulative Potential: Low, given hydrophilic nature, does not concentrate in organisms
Mobility in Soil: Highly water-soluble, can migrate in aquatic environment
Other Adverse Effects: Large releases may disrupt sewage treatment microbial communities, caution required if discharged in bulk
Waste Treatment Methods: Dispose of material as hazardous medical waste according to local and national regulations, use licensed chemical disposal contractor
Product Disposal: Incineration preferable if permitted, avoid release to environment
Contaminated Packaging: Contain residues in sealed bags or bins, label appropriately, follow chemical waste guidelines for plastics or glassware
Precautions: Do not discharge into drains, avoid contamination of ground or surface waters
UN Number: Not regulated as dangerous goods for transport
Transport Hazard Class: Not a hazardous chemical by UN ID or ADR/RID, IATA, IMDG standards
Packing Group: Not assigned
Special Precautions: Protect from moisture and sunlight, keep containers sealed and upright during shipment, avoid temperature extremes
Proper Shipping Name: Cefuroxime Sodium
Environmental Hazards: Not classified for marine pollutant status, but avoid bulk discharge
Transport Labels: No hazard label required, standard labeling for pharmaceutical intermediates advised
Safety, Health and Environmental Regulations: Not regulated as a hazardous substance under major international chemical control laws including OSHA, TSCA (US), REACH (EU), DSL (Canada) for pharmaceutical forms
Labelling Requirements: Handle as pharmaceutical substance; use workplace hazard labels for allergy and respiratory risk
Chemical Inventory Listings: Likely covered under exemption for substances in medicinal products according to region-specific regulatory authorities
Workplace Safety Recommendations: Provide occupational training for employees, maintain accessible MSDS, comply with exposure controls as set by national guidance
Other Information: Observe workplace hygiene, notify authorities in case of significant release or exposure incident, review updates to national and regional chemical safety texts routinely
