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Product Name: Cefuroxime; Cefuroxime Acid
Chemical Family: Cephalosporin antibiotic
Synonyms: (6R,7R)-7-[2-(2-Furyl)-2-(methoxyimino)acetamido]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Molecular Formula: C16H16N4O8S
Molecular Weight: 424.39 g/mol
Recommended Use: Pharmaceutical manufacture, research, synthesis of antibiotic medications
Manufacturer Information: Provided on commercial packaging or request
CAS Number: 55268-75-2 (Cefuroxime)
Emergency Contact: Listed on package insert or local Poison Center
GHS Classification: Not classified as hazardous according to GHS
Main Hazards: May cause allergic reactions if inhaled, ingested, or upon skin contact; respiratory or skin sensitization possible in those with penicillin allergies; dust can irritate respiratory tract
Signal Word: Warning
Hazard Statements: H317: May cause allergic skin reaction; H335: May cause respiratory irritation
Precautionary Statements: Avoid inhalation, skin, and eye contact; Do not eat, drink, or smoke during use; Use only with adequate ventilation; Wear protective equipment
Other Hazards: Not flammable, no known environmental bioaccumulation risk, may interfere with normal microflora in aquatic settings
Cefuroxime: ~98% w/w
Impurities: Less than 2%, proprietary, typically process-related or degradation products
Cefuroxime Acid: Varies based on supplier specifications; purity exceeds 98% w/w
Excipient/Carrier: None unless otherwise specified on lot certificate
Inhalation: Move affected person to fresh air; seek medical attention for acute reactions, wheezing, or shortness of breath; administer oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing immediately; wash skin thoroughly with soap and water; consult a physician if irritation or allergic reaction develops
Eye Contact: Rinse with large amounts of water for at least 15 minutes; remove contact lenses if present and continue rinsing; seek medical attention if irritation persists
Ingestion: Wash out mouth with water; seek immediate medical attention; never induce vomiting in an unconscious person
Important Symptoms: Allergic symptoms like rash, hives, breathing difficulty, swelling of lips/tongue/throat
Medical Attention: Personnel with known cephalosporin or penicillin allergies should avoid exposure or seek prompt evaluation if exposed
Suitable Extinguishing Media: Water spray, carbon dioxide, foam, dry chemical powder
Specific Hazards: Decomposition may produce hazardous fumes such as nitrogen oxides, sulfur oxides, carbon monoxide, and carbon dioxide
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective clothing
Fire/Explosion Properties: Non-flammable; no unusual fire or explosion hazard
Further Advice: Cool exposed containers with water spray; prevent run-off from entering drains or watercourses
Personal Precautions: Wear gloves, goggles, laboratory coat, and a dust mask; avoid contact with skin and eyes; prevent inhalation of dust
Environmental Precautions: Prevent spillage or washings from entering drains, environment or watercourses; report large releases
Spill Clean-up Methods: Sweep up without generating dust, place in a suitable, closed container for proper disposal; clean spill area thoroughly with water and detergent; ventilate area
Additional Measures: Use HEPA-filtered vacuum if powdered; avoid raising dust clouds or dispersing material by compressed air
Handling: Minimize dust formation; use in a chemical fume hood if available; avoid exposure if known allergy to beta-lactam antibiotics; do not eat, drink, or smoke in work area; wash hands after handling
Storage: Store in tightly sealed original container; keep in a cool, dry place, protected from light; maintain temperature recommended by supplier (usually 2–8°C for long-term stability); prevent unauthorized access
Incompatibilities: Avoid contact with oxidizing agents, acids or bases; consider segregation from strong reducing agents
Special Requirements: Regularly inspect storage containers for signs of physical breakdown or contamination
Control Parameters: No occupational exposure limits established; maintain lowest reasonable exposure
Engineering Controls: Local exhaust ventilation, fume hood, or enclosure recommended for quantities beyond small analytical amounts
Personal Protective Equipment: Nitrile gloves, safety goggles, laboratory coat or disposable suit, appropriate respiratory protection in absence of good ventilation
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, do not bring food/drinks into the laboratory, educate personnel on risks of antibiotic sensitization
Appearance: White to off-white crystalline or amorphous powder
Odor: Odorless
pH (1% solution): 4.0–7.0
Melting Point: Decomposes before melting, above 200°C
Boiling Point: Not applicable, decomposes
Solubility: Freely soluble in water, sparingly soluble in methanol, practically insoluble in chloroform and ether
Vapor Pressure: Not available, negligible
Partition Coefficient (logP): -1.8 to -2.0 (estimated)
Flash Point: Not applicable
Bulk Density: Ranges from 0.4 to 0.7 g/cm³ depending on granulation
Chemical Stability: Stable under recommended conditions; decomposes by hydrolysis, exposure to high heat, moisture, and strong light
Hazardous Reactions: None under normal use; hazard increases with presence of strong acids or bases that cause hydrolysis
Incompatible Materials: Avoid contact with oxidizing materials, alkalis, strong acids, strong reducing agents
Hazardous Decomposition Products: May give off oxides of sulfur, nitrogen, carbon during fire or intense heat
Polymerization: Will not occur
Acute Toxicity: Oral LD50 in rodents above 5,000 mg/kg, low acute toxicity
Chronic Toxicity: No direct evidence of carcinogenicity, mutagenicity, teratogenicity reported in standard laboratory animal studies
Health Hazards: Allergic reactions, including anaphylaxis, may occur in sensitized individuals; occupational exposure linked to rare cases of dermatitis or occupational asthma
Symptoms of Exposure: Rash, hives, redness, irritation, difficulty breathing, sneezing, eye discomfort
Sensitization: Risk higher for individuals with history of penicillin or cephalosporin allergy
Reproductive Toxicity: No evidence in animal studies; caution recommended during pregnancy
Target Organs: Skin, mucous membranes, respiratory tract
Other Effects: Overexposure may disturb healthy flora in exposed workers, particularly if ingestion occurs
Ecotoxicity: Cefuroxime exhibits broad-spectrum antibacterial activity, posing a risk to aquatic and soil microorganisms
Persistence and Degradability: Hydrolyzes gradually in neutral aqueous solution; photodegradable to some extent
Bioaccumulation Potential: Little or no bioaccumulation expected due to hydrophilic nature
Mobility: Expected to be mobile in aqueous environments due to high solubility
Effects in Environment: May disrupt wastewater treatment processes, alter microbial balance in effluent; avoid release to environment
Best Practice: Use only as needed, treat laboratory or production waste before release
Product Disposal: Collect unwanted material in labeled waste bags or sharps containers; dispose through approved pharmaceutical waste management companies
Contaminated Packaging: Rinse thoroughly; follow all applicable regulations for bioactive pharmaceuticals
Environmental Precautions: Prevent release to drains or sewers; do not discharge to surface waters; incineration in a facility compliant with government waste regulations
Waste Code: Generate under non-hazardous pharmaceutical waste unless contaminated by hazardous substances present on site
Special Instructions: Employees must follow institution-specific disposal protocols
UN Number: Not regulated as dangerous goods for transport
Proper Shipping Name: Cefuroxime compound, not subject to international transport regulations
Transport Hazard Class: Not applicable
Packaging Group: Not applicable
Marine Pollutant: Not listed
Special Transport Precautions: Use leak-proof, sealed containers; protect from physical damage and moisture; maintain temperature as recommended
Labeling: Must bear clear labeling with antibiotic type, purity, batch number, and hazard indication
Health and Safety Regulations: Occupational exposure monitoring advised for large-volume handling facilities; subject to pharmaceutical GMP
TSCA Status (USA): Not listed for industrial use
OSHA Hazards: May be classified as a sensitizer
Other Local/International Standards: Meets requirements for FDA, EMA, and corresponding national health agencies for drug manufacturing
REACH Status: Exempt for use in medicinal products under Annex V
Hazard Pictograms: Skin sensitizer, respiratory irritant where applicable
Employer Responsibilities: Provide training, ensure PPE use, maintain MSDS access, conduct appropriate risk assessments before work involving cephalosporin compounds
