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Product Name: Ceftizoxime Sodium
Chemical Formula: C13H12N5NaO5S2
Synonyms: Ceftizoxime Disodium Salt
CAS Number: 68401-82-1
Intended Use: Pharmaceutical intermediate, antibiotic agent
Manufacturer: [Manufacturer information supplied separately as required]
Emergency Contact: Refer to local poison control centers or emergency medical support
Classification: Not classified under GHS for acute toxicity, skin sensitization, or specific target organ toxicity
Signal Word: Warning
Hazard Statements: May cause allergic reactions, respiratory irritation, and skin or eye irritation in sensitive individuals. Respiratory symptoms may occur if inhaled in powdered form.
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with eyes, skin, or clothing. Use only in well-ventilated areas. Do not breathe dust or powder.
Ceftizoxime Sodium: 98%–101%
Other Ingredients: Trace sodium salts, water (up to 2%), potential impurities from manufacturing within acceptable pharmacopoeial limits
Inhalation: Move person into fresh air. Provide oxygen or artificial respiration if breathing is difficult. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash affected area with soap and plenty of water. Seek medical help if signs of irritation or sensitization appear.
Eye Contact: Rinse with plenty of water for at least 15 minutes, holding eyelids open. Seek immediate medical advice.
Ingestion: Rinse mouth and drink water if the person is alert. Do not induce vomiting unless advised by medical personnel. Contact poison control or a physician immediately.
Most Important Symptoms: Possible allergic response, nausea, respiratory difficulty, rash or itching.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: None identified based on routine handling
Special Hazards: Thermal decomposition may produce toxic fumes of nitrogen oxides, sulfur oxides, and sodium compounds
Advice for Firefighters: Use self-contained breathing apparatus and full protective gear. Control runoff to prevent contamination of waterways.
Personal Precautions: Wear gloves, protective mask, goggles, and laboratory gown. Avoid raising dust.
Environmental Precautions: Prevent spillage from entering drains or waterways.
Methods for Cleanup: Sweep up powder carefully without generating dust. Place in a secure, closed container for disposal following local regulations. Clean contaminated area with water and soap.
Handling: Avoid breathing dust or powder. Use appropriate personal protective equipment. Work in well-ventilated space or a chemical fume hood.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat, drink or smoke in work areas.
Storage: Keep container tightly closed. Store in a dry, cool, well-ventilated place away from direct sunlight and sources of moisture.
Conditions to Avoid: Exposure to moisture, high temperatures
Engineering Controls: Local exhaust or fume extraction recommended
Personal Protective Equipment: Laboratory gloves (nitrile or latex), safety glasses with side shields, laboratory coat
Respiratory Protection: Suitable NIOSH-approved mask when powder dust may be generated.
Environmental Protections: Close systems or containment procedures for bulk handling to minimize risk of release.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint medicinal odor
pH: 4.5–7.5 (5% solution in water)
Melting Point: Decomposes above 200°C
Solubility: Freely soluble in water, slightly soluble in ethanol
Boiling Point: Not applicable – decomposes on heating
Molecular Weight: 467.39 g/mol
Flash Point: Not determined
Vapor Pressure: Not applicable
Chemical Stability: Stable under routine storage conditions as recommended
Conditions to Avoid: Moisture, extended exposure to light, high temperature
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, sodium oxide, irritating fumes
Reactivity: No hazardous reactions occur under normal processing and storage
Acute Toxicity: LD50 (oral, rat) > 2000 mg/kg – low toxicity by ingestion
Local Effects: May cause transient irritation to skin, eyes, or respiratory tract
Sensitization: Allergic skin or respiratory responses possible, especially in individuals with penicillin or cephalosporin allergies
Chronic Toxicity: No known chronic effects in workplace conditions; possible gut disturbance if ingested in large amounts
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Mutagenicity: No known mutagenic effects based on available data
Further Information: Those handling the product frequently should undergo regular health checks for signs of sensitization or allergy
Ecotoxicity: Low acute aquatic toxicity expected based on structure and pharmacological activity
Degradability: Readily bio-degradable under natural conditions
Bioaccumulation: No significant potential for bioaccumulation
Mobility in Soil: Highly water-soluble; may migrate in moist soil but remains bioavailable for microbial degradation
Adverse Environmental Effects: Avoid large uncontrolled releases, as with many pharmaceuticals
Product Disposal: Dispose in incinerator or chemical landfill approved for pharmaceutical waste. Comply with local, state, and national regulations.
Container Disposal: Triple rinse containers, then destroy or recycle as permitted by local law
Precautions: Do not allow material or rinse water to reach sewers or waterways
UN Number: Not regulated as dangerous goods under ADR, RID, IMDG, or IATA
Proper Shipping Name: Ceftizoxime Sodium
Transport Hazard Class: No hazard class
Packing Group: None required
Special Precautions: Protect from moisture, excessive heat; ship in sealed original packaging
Inventory Status: Listed in national and international chemical inventories where required for pharmaceutical intermediates
Risk Phrases: R42 – May cause sensitization by inhalation
Safety Phrases: S22, S24/25 – Do not breathe dust; avoid contact with skin and eyes
US Regulations: Not subject to SARA Title III or CERCLA reporting requirements
EU Regulations: Not considered hazardous under CLP Regulation
Labelling: Appropriate hazard labeling for workplace and transport
Other Regulations: Handle according to local occupational safety and health guidelines
