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Product Name: Ceftiofurin
Chemical Family: Cephalosporin antibiotic
Synonyms: Ceftiofur sodium, Excenel, Naxcel
CAS Number: 80370-57-6
Recommended Use: Veterinary antibiotic for bacterial infections
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GHS Classification: Eye irritation (Category 2), Skin sensitizer (Category 1), Respiratory sensitizer (Category 1)
Label Elements: Signal word: Warning
Hazard Statements: Causes serious eye irritation, may cause allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements: Wear personal protective equipment, avoid breathing dust or aerosols, wash hands thoroughly after handling, avoid contact with skin and eyes
Potential Health Effects: Inhalation may trigger respiratory hypersensitivity, repeated skin contact increases risk of eczema, accidental eye exposure causes burning and redness
Environmental Hazards: Harmful to aquatic life with long-lasting effects; avoid environmental release
Ceftiofur Sodium: 90-98%
Water: 1-5%
Stabilizers: <1%
Impurities: Trace, not expected to contribute significantly to toxicity
Other information: Product contains no components known to be carcinogenic at or above threshold limits set by OSHA.
Inhalation: Move to fresh air, monitor breathing, seek medical attention for persistent cough or difficulty breathing
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, call a doctor if irritation or rash appears
Eye Contact: Rinse carefully with plenty of water for at least 15 minutes, remove contact lenses if present, seek prompt medical attention
Ingestion: Rinse mouth, drink water if alert, never give anything by mouth to an unconscious person, obtain medical advice immediately
Most important symptoms: Allergic reactions, asthma-like symptoms, dermatitis
Special instructions: Treat symptomatically and supportively; inform treating physician of exposure to cephalosporin compounds
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Unsuitable Extinguishing Media: High volume water jet may spread powder
Special Exposure Hazards: Thermal decomposition produces toxic fumes such as nitrogen oxides, sulfur oxides, carbon oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective suit
Personal Precautions: Stay upwind of fire, avoid inhalation of dust, prevent runoff
Other Information: Containers may explode if heated; keep cool with water spray if safe to do so
Personal Precautions: Use appropriate personal protective equipment, avoid dust formation, ensure ventilation
Environmental Precautions: Prevent spillage from entering drains, surface water, or soil
Spill Clean-Up Methods: Sweep up and collect in suitable containers for disposal; avoid creating dust, contain and collect spillage with non-combustible absorbent material such as sand; wash spill area thoroughly
Disposal: Dispose of collected waste as required by local regulations
Handling: Avoid exposure by inhalation, skin, or eye contact; use only in well-ventilated areas; practice good industrial hygiene and safety procedures
Storage: Store in a tightly closed, labelled container in a cool, dry, and well-ventilated place away from incompatible chemicals; limit access to trained personnel; protect from direct sunlight and moisture
Incompatible Materials: Avoid storing near acids, strong oxidizing agents; separate from foods and feedstuffs
Specific Use: Only trained professionals should handle bulk drug substance; minimize environmental contamination
Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels below recommended exposure limits
Personal Protection: Respirator approved for dusts and powders if ventilation is insufficient; chemical-resistant gloves (e.g., nitrile), eye protection (goggles or face shield), laboratory coat or full suit as appropriate
Hygiene Measures: Wash hands before breaks and after work; do not eat, drink, or smoke while handling
Occupational Exposure Limits: No OSHA PEL or ACGIH TLV established, but minimize occupational exposure as much as possible
Environmental Exposure: Follow best practices to avoid release into water, soil, or air; treat process water on site or at local facility
Appearance: White to pale yellow crystalline powder
Odor: Slight characteristic odor
Odor Threshold: Not determined
pH: 4.5-6.5 (10% solution)
Melting Point/Freezing Point: Not established (decomposes)
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Not classified as flammable
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: 1.5-1.7 g/cm³
Solubility: Freely soluble in water, insoluble in organic solvents
Partition Coefficient (n-octanol/water): Not available
Auto-Ignition Temperature: Not available
Decomposition Temperature: >180°C
Viscosity: Not applicable
Chemical Stability: Stable at normal temperature and pressure under recommended conditions
Reactivity: Inert to most common reagents, sensitive to strong acids and oxidizers
Conditions to Avoid: Moisture, extreme heat, direct sunlight, freezing temperatures
Incompatible Materials: Strong acids, alkalis, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon oxides, irritating gases and vapors
Polymerization: Product will not undergo dangerous polymerization
Acute Toxicity: Oral LD50 (rat) >2000 mg/kg; low acute toxicity by dermal and inhalation routes
Skin Corrosion/Irritation: Mild to moderate irritation on prolonged contact
Eye Damage/Irritation: Causes serious eye irritation
Respiratory Sensitization: Cephalosporins can cause respiratory allergies in susceptible individuals
Skin Sensitization: Repeated or prolonged contact may cause allergic dermatitis
Carcinogenicity: No evidence found in animal studies; not classified as a human carcinogen
Mutagenicity: Not mutagenic in standard in vitro/in vivo tests
Reproductive Toxicity: Animal studies show no adverse reproductive effects at veterinary doses
Repeated Dose Toxicity: Target organs: skin, respiratory tract
Medical Conditions Aggravated by Exposure: Individuals with known allergies to beta-lactams, history of eczema or asthma
Ecotoxicity: Toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Not readily biodegradable; hydrolyzes slowly in soil and water
Bioaccumulative Potential: Expected to be low due to water solubility and rapid excretion in animals
Mobility in Soil: Product migrates in water; risk of contamination in surface and groundwater
Other Adverse Effects: Large-scale release can disrupt microbial communities in soil and water; avoid direct application or disposal in sensitive environments
Waste Treatment Methods: Dispose of in accordance with local, regional, national, and international regulations
Product Disposal: Incinerate or landfill under controlled conditions approved for hazardous pharmaceutical waste
Packaging Disposal: Rinse containers before recycling or disposal; dispose as hazardous waste if contaminated
Additional Information: Do not discharge into drains or the environment; collect and treat all liquid waste
UN Number: Not regulated by ADR/RID/IMDG/IATA
Proper Shipping Name: Not regulated for transport
Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Protect from extreme temperatures and moisture during transport
Environmental Hazards: Not classified as marine pollutant
Transport in Bulk: Do not transport in bulk unless in dedicated, secure containers
OSHA Status: Product does not contain hazardous ingredients at levels requiring notification
EPA Regulations: Not listed as hazardous under RCRA; avoid environmental contamination
TSCA: Not listed
REACH Status: Exempt for veterinary medicinal use
SARA Title III: Not subject to reporting under Sections 302, 304, 311, 312, or 313
Other Regulatory Information: Ceftiofurin classified under veterinary prescription medicines; follow all local licensing and safe handling requirements
Workplace Classification: Use engineering controls and PPE as outlined by site-specific risk assessment
