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Product name: Ceftiofur Hydrochloride
Chemical family: Cephalosporin antibiotic
Synonyms: Ceftiofur HCl
CAS Number: 103980-44-5
Intended use: Veterinary pharmaceutical ingredient for bacterial infections
Manufacturer Information: Provided upon legitimate inquiry
Emergency phone: Available on packaging or via your local poison control center
Relevant identified uses: Formulation and preparation of veterinary drugs; not intended for human consumption or direct administration without veterinary supervision
Classification: Respiratory sensitizer (Category 1), Skin sensitizer (Category 1), Eye irritant (Category 2A)
Signal word: Warning
Hazard statements: May cause allergy or asthma symptoms or breathing difficulties if inhaled; may cause an allergic skin reaction; causes serious eye irritation
Symptoms of exposure: Skin rash, itching, respiratory discomfort, watery or irritated eyes
Pictograms: Exclamation mark; Health hazard
Precautionary statements: Avoid breathing dust; wash hands thoroughly after handling; wear protective gloves, clothing, eye, and face protection; if experiencing respiratory symptoms, seek medical advice
Ceftiofur Hydrochloride: 98-100%
Impurities: Less than 2% (manufacturing byproducts, not considered hazardous in this context)
Molecular formula: C19H18N5O7S3 • HCl
Molecular weight: 584.03 g/mol (Hydrochloride form)
Active ingredient purity: Minimum 98%
Inhalation: Move person outdoors to fresh air immediately; seek medical attention if respiratory symptoms occur
Skin contact: Remove contaminated clothing; wash affected skin with plenty of soap and water; consult physician if rash or irritation develops
Eye contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; get medical help in case of persistent irritation
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical advice right away or contact poison control
Self-protection: Use gloves, mask, and goggles in case of any direct handling during rescue efforts
Suitable extinguishing media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable extinguishing media: High-pressure water jets (may cause powder to disperse)
Special hazards: Combustible, may emit toxic fumes (carbon oxides, nitrogen oxides, sulfur oxides, hydrogen chloride) in case of fire
Protective equipment: Self-contained breathing apparatus and full protective clothing
Firefighting instructions: Isolate fire area, avoid inhaling fumes or dust; cool containers with water spray to prevent rupture from heat
Personal precautions: Wear disposable gloves, dust mask or respirator, protective eyewear, and a laboratory coat
Spill response: Stop source of the spill; avoid dust formation; sweep up using non-sparking tools and transfer to an appropriate waste container
Environmental precautions: Prevent from entering drains, soil, and surface water
Clean-up procedures: Ventilate area after spillage; wash the spill site thoroughly with water and detergent; dispose of all contaminated materials in accordance with local regulations
Handling: Process in a well-ventilated location; limit airborne exposure by using closed systems or local exhaust; avoid direct contact with substance
Hygiene measures: Prohibit eating, drinking, or smoking in handling areas; wash hands after use
Storage: Store in tightly-sealed original container, away from direct light and humidity; maintain temperature at 15-30 °C in a dry, secure area outside of reach for unauthorized personnel or animals; keep separate from incompatible chemicals (strong oxidizers, acids, bases)
Engineering controls: Local exhaust ventilation, glove boxes, or closed system handling
Respiratory protection: NIOSH-approved particulate respirator if airborne concentration exceeds threshold
Skin protection: Chemical-resistant gloves (nitrile, latex), long-sleeved lab coat
Eye/face protection: Approved safety goggles or face shield
Exposure limits: No specific occupational exposure limit established, but minimize to lowest feasible level as for pharmaceutical actives
Environmental exposure controls: Avoid release to environment; contain wash water from cleaning
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (solution): 3.5–5.5 (10% aqueous solution)
Melting point: Not clearly defined (decomposes before melting)
Boiling point: Decomposes
Solubility: Freely soluble in water; slightly soluble in methanol and ethanol
Partition coefficient: Not available
Vapor pressure: Not applicable; non-volatile solid
Flash point: Not applicable
Density: 1.4–1.5 g/cm³
Evaporation rate: Not applicable
Stability: Stable under recommended storage conditions
Chemical stability: Stable if kept cool and dry in sealed containers
Possibility of hazardous reactions: Dust may form explosive mixtures in air at high concentrations; avoid sources of ignition
Incompatible materials: Strong acids, strong bases, oxidizing agents
Decomposition products: Upon heating, produces toxic gases including carbon monoxide, carbon dioxide, nitrogen oxides, sulfur compounds, and hydrogen chloride
Conditions to avoid: Humidity, elevated temperature, direct sunlight, sources of ignition
Acute toxicity: Low acute oral and inhalation toxicity in mammals
Routes of exposure: Inhalation, ingestion, skin, eyes
Skin corrosion/irritation: May cause irritation and allergic reactions
Serious eye damage/irritation: Can provoke eye irritation
Respiratory sensitization: Known respiratory sensitizer; individuals with allergies to beta-lactam antibiotics may develop severe reactions
Germ cell mutagenicity: Not classified based on available studies
Carcinogenicity: No evidence found in animal studies
Reproductive toxicity: Not observed in standard testing; use caution due to lack of complete data
Other information: Chronic exposure may cause sensitization or other allergic reactions in some people
Ecotoxicity: Harmful to aquatic organisms; avoid release into the environment
Persistence and degradability: Not rapidly biodegradable; can persist in water and soil
Bioaccumulative potential: Not expected to bioaccumulate significantly due to high water solubility
Mobility in soil: May migrate through soil and contaminate water
Other adverse effects: Antibiotic activity may interfere with wastewater treatment microbial activity
Product: Collect and store remaining material as hazardous waste; incinerate or dispose in approved facility in compliance with local, regional, and national regulations
Contaminated packaging: Avoid re-use; destroy containers after triple rinsing and ensure complete disposal in accordance with legal requirements
Environmental precautions: Do not allow material to reach surface waters, sewage system, or soil
Special considerations: Notify local authorities if release occurs in large amounts
UN Number: Not regulated for ground or air transport under normal conditions
Proper shipping name: Ceftiofur Hydrochloride
Hazard class: Not classified as hazardous
Packing group: Not assigned
Environmental hazards: Not a marine pollutant, but due to antibiotic properties, treat as environmentally sensitive material
Transport precautions: Store in secure, dry containers during transit; avoid physical shock or vibration; label and seal properly
US Regulation: Listed under the Federal Food, Drug, and Cosmetic Act as a veterinary pharmaceutical; not subject to OSHA hazard label requirements but managed as hazardous due to sensitization risk
EU Regulation: Regulation (EC) No 1907/2006 (REACH), not classified as a hazardous substance but managed as potentially sensitizing or irritating
Other regulations: Subject to safe handling, storage, disposal, and environmental control requirements under other country-specific pharmaceutical and hazardous material standards
Safety assessment: Must comply with Good Manufacturing Practices (GMP) and control for occupational exposure and environmental protection
Workplace labeling: Clear hazard communication required in all handling areas
