© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product name: Ceftezole Sodium
Chemical family: Beta-lactam antibiotic, Cephalosporin derivative
Synonyms: Ceftezole sodium salt, Ceftizoxime sodium
CAS number: 38996-35-7
Molecular formula: C19H15N8NaO5S3
Molecular weight: 570.56
Recommended use: Laboratory research, pharmaceutical use subject to health oversight
Supplier/Manufacturer: Pharmaceutical companies or research labs registered for antibiotic storage
Emergency contact: Local regulatory authorities or national poison control center
GHS classification: Eye irritation (Category 2A), Skin sensitization (Category 1), Specific target organ toxicity (single exposure, Category 3), Respiratory sensitization (Category 1)
Signal word: Warning
Hazard statements: Causes serious eye irritation. May cause respiratory irritation and allergic skin reactions. May cause symptoms typical for cephalosporin allergies in sensitive individuals.
Precautionary statements: Avoid breathing dust. Wash hands after handling. Use only in well-ventilated areas.
Main routes of exposure: Inhalation, skin, and eyes
Ceftezole sodium: ≥98%
Impurities: ≤2% (unreacted starting materials, degradants, residues from synthesis)
Inactive components: None intentionally present
Additives: None reported
Ingestion: Rinse mouth thoroughly with water, seek medical attention, provide symptomatic care; risk of allergic reaction in susceptible individuals.
Inhalation: Move person to fresh air, monitor for breathing difficulty, seek medical attention; asthma-like symptoms possible.
Skin contact: Remove contaminated clothing, wash skin with plenty of water and soap, watch for rash or irritation, get medical help if symptoms persist.
Eye contact: Immediately flush with plenty of clean, lukewarm water for at least 15 minutes, consult healthcare provider if discomfort persists.
Most important effects: Allergic reactions, difficulty breathing, skin and eye irritation, delayed hypersensitivity
Suitable extinguishing media: Water spray, dry chemical powder, carbon dioxide, alcohol-resistant foam
Unsuitable extinguishing media: No known incompatibilities with standard agents
Specific hazards: Thermal decomposition releases toxic gases such as sulfur oxides, nitrogen oxides, carbon monoxide, sodium compounds
Protective equipment for fire-fighters: Self-contained breathing apparatus, full protective gear
Recommendations: Avoid inhaling vapors or dust; contain runoff to prevent environmental contamination
Personal precautions: Use personal protective equipment (goggles, gloves, mask), avoid dust generation, ventilate the area
Environmental precautions: Prevent further release or spillage if safe, avoid entry into drains or water bodies
Cleanup methods: Scoop up solid material without generating dust, transfer to an approved, labeled container for disposal; wipe residue with wet towel or mop followed by soap and water
Disposal: Dispose according to local, national, or regional regulations
Handling: Use only in a chemical fume hood or well-ventilated area, wear appropriate PPE, avoid ingestion, inhalation, or contact with skin and eyes, minimize dust formation and accumulation
Storage: Store in tightly sealed, labeled containers, away from moisture and incompatible materials, in a cool, dry, well-ventilated place
Incompatible substances: Strong oxidizers, acids, bases, and reducing agents
Occupational Exposure Limits: Not established for Ceftezole sodium; follow good laboratory practices
Engineering controls: Use process enclosures or local exhaust ventilation to keep airborne levels low
Personal protective equipment: Safety goggles, laboratory gloves (nitrile or latex), lab coat, NIOSH-certified dust respirator if powder handling is involved, closed footwear
Hygiene measures: Wash hands before breaks and after handling, do not eat or drink in work area, keep work clothing separate
Appearance: White to off-white crystalline powder
Odor: Faint or none
Odor threshold: Not applicable
pH (1% solution): 4.5–6.5
Melting point: 190–205°C (decomposition)
Boiling point: Not applicable (decomposes)
Flash point: Not flammable
Flammability: Non-combustible
Vapor pressure: Not applicable
Solubility: Freely soluble in water, slightly soluble in methanol, practically insoluble in ethanol, chloroform, and ether
Partition coefficient (log Pow): Not established
Auto-ignition temperature: Not determined
Decomposition temperature: Above 205°C
Viscosity: Not applicable
Chemical stability: Stable under recommended storage conditions
Hazardous reactions: No dangerous reaction under normal use
Conditions to avoid: Excessive heat, strong light, moisture or humidity
Incompatible materials: Strong acids, strong bases, oxidizing and reducing agents, heavy metals
Hazardous decomposition products: Nitrogen oxides, sulfur oxides, sodium oxides, carbon monoxide
Acute toxicity: Oral LD50 (rat): >5000 mg/kg (low acute toxicity by oral route), based on related compounds
Skin corrosion/irritation: May cause mild irritation in direct contact
Eye damage/irritation: Causes serious eye irritation
Respiratory sensitization: May cause asthma-like symptoms or allergy after repeated exposure
Skin sensitization: Risk of allergic reactions, particularly in individuals sensitive to beta-lactam antibiotics
Chronic effects: Prolonged or repeated exposure can aggravate respiratory allergies
Mutagenicity, carcinogenicity, reproductive toxicity: Not classified as a mutagen, carcinogen, or reproductive toxin based on available data
Potential health symptoms: Itching, rash, difficulty breathing, swelling of face or throat, gastrointestinal upset in susceptible persons
Toxicity: Not expected to be highly toxic to aquatic or terrestrial life, but large amounts may disrupt microbial populations
Persistence and degradability: May undergo slow degradation in soil and water; little biodegradation in water treatment systems
Bioaccumulative potential: Low, due to moderate water solubility and molecular weight
Mobility in soil: Can move into water systems from soil, especially if spilled
Other adverse effects: No data for chronic impact on wildlife, but antibiotic contaminants can foster antimicrobial resistance in the environment
Waste disposal methods: Send unused product and contaminated material to authorized hazardous waste treatment facility
Container disposal: Triple rinse container, then puncture and dispose according to local chemical waste regulations
Disposal precautions: Prevent product entry to natural water sources; avoid landfill disposal
Regulatory compliance: Follow local, state, and national regulations regarding disposal of antibiotics and infectious substances
UN number: Not regulated under current ADR, IATA, or IMDG codes for road, air, or maritime transport
Proper shipping name: Not regulated; if mixed with hazardous materials, follow specific protocols
Transport hazard class: None assigned
Packing group: Not applicable
Special precautions: Ensure container is intact, sealed, and clearly labeled; avoid temperature extremes during shipping
EMERGENCY Guidebook number: Not assigned
US regulations: Not regulated as a hazardous chemical under OSHA, but subject to FDA pharmaceutical regulations for manufacture and handling
TSCA inventory: Not listed; for pharmaceutical use, not for general commercial application
EU regulations: Not classified under REACH, but must comply with biopharmaceutical regulations
WHMIS Classification (Canada): D2B (Toxic Material Causing Other Toxic Effects)
Other regulations: Use is restricted to appropriately credentialed facilities; access and use tracked for public health oversight
International regulations: Verification procedures in place by WHO, EMA, and equivalent national agencies for handling of active pharmaceutical ingredients
