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Product Name: Ceftazidime Sodium Carbonate
Chemical Family: Beta-lactam antibiotic / carbonate salt blend
Recommended Uses: Active pharmaceutical ingredient, laboratory reagent
Synonyms: Ceftazidime disodium with sodium carbonate
Manufacturer: [Manufacturer information required]
Emergency Contact Number: [Available emergency contact required]
CAS Number: 78439-06-2 (Ceftazidime), 497-19-8 (Sodium carbonate)
Classification: Eye irritant, respiratory sensitizer, skin sensitizer, not expected to be flammable, possible environmental hazard
Signal Word: Warning
Hazard Statements: May cause allergic reactions or respiratory symptoms in people with penicillin/cephalosporin allergies, causes eye and skin irritation, may impact waterways
Precautionary Statements: Handle in a well-ventilated area, avoid creating dust, wear protective equipment, avoid inhalation, contact with eyes and skin
Label Pictograms: Exclamation mark, health hazard symbol
Other Hazards: Not expected to generate acute toxicity through ingestion under normal handling; cytotoxicity not observed in routine use, but sensitization risk exists
Main Component: Ceftazidime sodium
Concentration (Approximate): 70-80%
CAS Number: 78439-06-2
Supporting Excipient: Sodium Carbonate
Concentration (Approximate): 20-30%
CAS Number: 497-19-8
Impurities: May contain trace manufacturing byproducts, none of significant hazard under standard use
Eye Contact: Rinse gently with water for at least 15 minutes, keep eyelids open, seek medical attention if irritation or vision changes persist
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, medical evaluation for rash or persistent irritation
Inhalation: Move person to fresh air, seek immediate medical evaluation in case of symptoms like breathing difficulty, wheezing, or chest tightness
Ingestion: Rinse mouth, seek medical attention, do not induce vomiting unless directed by medical personnel
Note to Physicians: Ceftazidime reactions may mirror those of other beta-lactam antibiotics (rash, anaphylaxis), provide symptomatic and supportive care
Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Hazards from Combustion: Can produce nitrogen oxides, sulfur oxides, sodium oxides, and carbon oxides under combustion
Protective Equipment: Wear self-contained breathing apparatus and protective suit to avoid inhalation of fumes
Specific Hazards: Powder form can become airborne, may cause respiratory irritation for responders without protection
Advice for Firefighters: Approach from upwind to avoid exposure to smoke, use non-combustible covering for containment if possible
Personal Protection: Wear chemical splash goggles, N95 or higher respirator, and gloves, avoid dust generation
Environmental Precautions: Prevent runoff into sewers, water bodies, or soil to reduce contamination
Methods for Containment: Collect released product using HEPA-filtered vacuum or damp methods, carefully transfer to sealed container for disposal
Clean-Up: Avoid dry sweeping, ventilate area, carefully wipe residues, dispose of cleaning materials in accordance with local regulations
Reporting: Notify relevant safety, health authorities if large quantities are released to minimize community risk
Handling: Engineering controls limit exposure to airborne powder, avoid contact with skin and eyes directly, do not eat, drink, or smoke in handling area
Hygiene Measures: Wash hands after handling, decontaminate equipment and surfaces regularly
Storage Conditions: Store in original, tightly sealed container at 2–8°C, protect from moisture and light
Incompatibilities: Strong acids, oxidizing agents, avoid moisture as hydrolysis may reduce efficacy and stability
Packaging Requirements: Use shatter-resistant and moisture-impermeable bottles or bags, prevent accidental release via secondary containment
Occupational Exposure Limits: None established for ceftazidime or sodium carbonate, practice general dust control
Engineering Controls: Use local exhaust ventilation and HEPA filtration
Protective Equipment: Safety goggles, lab coats, nitrile gloves, and dust masks or respirators offering particulate protection
Environmental Controls: Isolate work areas, use closed systems where possible, implement spill response supplies
Personal Hygiene: No food, drink, or smoking in laboratory, immediate wash procedures for accidental contact
Appearance: White to pale yellow crystalline powder
Odor: Odorless or mild pharmaceutical odor
pH: 5.0–7.5 (1% solution in water)
Solubility: Freely soluble in water, practically insoluble in organic solvents
Melting Point: Decomposes before melting
Vapor Pressure: Not volatile at ambient conditions
Molecular Weight: 636.6 g/mol (Ceftazidime sodium), 106 g/mol (Sodium carbonate)
Partition Coefficient: Not applicable
Other Physical Properties: Stable as a dry powder under recommended storage, sensitive to prolonged exposure to light and moisture
Chemical Stability: Stable under recommended storage, hydrolyzes in aqueous solutions over time
Hazardous Reactions: Not expected during standard use, but decomposes in contact with acids or oxidizers
Incompatible Materials: Acidic substances, strong oxidizers, excessive heat, moisture
Decomposition Products: Sulfoxides, ammonia, CO2, nitrogen oxides, sodium oxide, depending on conditions
Conditions to Avoid: Exposure to direct sunlight, repeated freeze-thaw cycles, high humidity environments
Acute Toxicity: Low oral toxicity expected, not known to cause acute effects in low-exposure settings
Skin Corrosion/Irritation: Possible mild irritation, allergic dermatitis in sensitized individuals
Eye Damage/Irritation: Irritating on direct contact, redness and tearing possible
Respiratory Sensitization: Prolonged or repeated inhalation may cause allergic reactions, particularly in people with sensitivities to cephalosporins
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity: No significant evidence from animal studies or clinical exposure
Reproductive Toxicity: No established reproductive effects, limited human data
Chronic Effects: Allergic sensitization, rare cases of anaphylaxis, delayed allergic reactions possible
Ecotoxicity: Not highly toxic to aquatic organisms at low environmental concentrations, but antibiotics can disrupt microbial processes
Persistence and Degradability: Degrades slowly in aquatic environments, breakdown products may persist for weeks
Bioaccumulation: Not expected to significantly bioaccumulate in aquatic or terrestrial species
Mobility in Soil: Mobile in water due to high solubility, limited adsorption on most soils
Other Adverse Effects: Antibiotic resistance may arise in microbes from continuous low-level exposure in the environment
Product Disposal: Dispose of via incineration or other high-temperature destruction in a licensed chemical waste handler
Contaminated Packaging: Dispose of in compliance with local, regional, and federal regulations, prevent reuse
Waste Codes: Non-hazardous chemical waste, but confirm with local authority
Precautions: Avoid direct release into sewage, waterways, or general landfill
Spill Clean-Up Materials: Dispose along with the product using compatible containers, segregate from general waste streams
UN Number: Not regulated as a dangerous good for land, sea, or air transport
Transport Hazard Class: None assigned
Packing Group: Not regulated
Special Precautions: Protect from direct sunlight and moisture, prevent container breakage
Shipping Name: Ceftazidime Sodium Carbonate, Pharmaceutical Chemical
Land Transport (ADR/RID): Not classified as hazardous material
IMO/IATA Regulations: Not regulated, pack to prevent accidental release
Regulatory Status: Regulated as an antibiotic active in finished pharmaceuticals, not listed as hazardous under major chemical control acts
Inventory Listings: Components listed on TSCA (US), EINECS (EU), AICS (Australia), DSL (Canada)
Labeling Requirements: Pharmaceutical workplace labeling, hazard communication for sensitization and irritancy
OSHA: No specific occupational standard
SARA Title III: Not listed as hazardous substance
REACH (EU): Registered for use as an intermediate or reagent
Other Regulatory Information: Not controlled as a narcotic, precursor, or toxic chemical; safety data available for worker protection and environmental impact
