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Product Name: Cefradine Oral Grade, Pure Powder
Chemical Name: Cefradine
CAS Number: 38821-53-3
Recommended Use: Pharmaceutical ingredient for oral formulations
Supplier Info: Manufacturer or distributor name, contact details including address, emergency phone number
Synonyms: Cephradine, Cefradin
Emergency Contact Number: Dedicated 24-hour response number for chemical emergencies
GHS Classification: Not classified as hazardous under GHS for supplied form
Main Health Hazards: Potential allergen; can cause skin, eye, or respiratory irritation. May provoke allergic reactions in sensitized individuals, especially those with beta-lactam antibiotic allergy
Label Elements: Pictogram not required for GHS; precautionary statements for handling respiratory sensitizers apply
Signal Word: Warning
Precautionary Statements: Avoid inhalation and direct contact; use personal protective gear
Substance: Cefradine oral-grade powder, 100% pure
Chemical Formula: C16H19N3O4S
Impurities: At pharmaceutical specification, no significant impurities
Molecular Weight: 349.4 g/mol
Eye Contact: Rinse immediately with water for at least 15 minutes, keep eyelids open, seek medical attention if irritation develops
Skin Contact: Remove contaminated clothing, wash with soap and water, obtain medical help for persistent burning or allergic symptoms
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, seek medical advice if symptoms occur
Ingestion: Rinse mouth, seek medical assessment; do not induce vomiting unless directed by medical personnel
Advice to Doctor: Treat symptomatically, monitor for signs of allergic response, consider known patient allergies
Suitable Extinguishing Media: Use water spray, coal-dioxide, foam, or dry chemical< br>
Specific Hazards: Incomplete combustion may produce toxic fumes such as oxides of nitrogen, sulfur, and carbon monoxide
Protective Equipment: Firefighters use self-contained breathing apparatus and chemical protective clothing
Special Procedures: Cool exposed containers with water spray, prevent runoff from entering sewers and waterways
Personal Precautions: Evacuate area, wear suitable respiratory protection, avoid dust formation
Environmental Precautions: Prevent release into environment, contain powder to prevent contamination of soil and water
Cleanup: Collect without generating dust, place in labeled waste containers, ventilate area following cleaning
Disposal: Dispose of according to regulatory guidelines for pharmaceutical chemicals
Handling: Handle in well-ventilated areas, avoid breathing dust, prevent skin or eye contact, wear personal protective equipment
Storage: Store tightly closed in original container, keep away from direct sunlight, moisture, and heat; ideally between 2–8°C
Technical Measures: Use local exhaust ventilation, store away from incompatible materials like strong oxidizing agents
Hygiene Practices: Wash hands after handling, avoid eating and drinking near chemical
Workplace Exposure Limits: No specific OSHA, ACGIH, or NIOSH limits established for cefradine; control exposure via fume hoods and local extraction
Engineering Controls: Local exhaust ventilation, safety enclosure for weighing and dispensing
Personal Protective Equipment (PPE): Protective gloves (nitrile or latex), chemical splash goggles, disposable lab coats, N95 or better respirator when powdering
Environmental Controls: Prevent dust release into working atmosphere
Appearance: White or almost white crystalline powder
Odor: Odorless or faint medicinal smell
pH: 3.5–5.5 (50 mg/mL suspension in water)
Solubility: Sparingly soluble in water, practically insoluble in organic solvents
Melting Point: Decomposes above 220°C, no distinct melting
Boiling Point: Not applicable, decomposes before boiling
Vapor Pressure: Not applicable
Partition Coefficient (Log Pow): Not determined
Chemical Stability: Stable under standard conditions, sensitive to moisture and heat, gradually degrades with prolonged exposure
Hazardous Reactions: May react with strong oxidizers; hydrolyzes slowly in aqueous solutions
Incompatible Materials: Strong acids and bases, oxidizing agents
Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide upon thermal decomposition
Acute Toxicity: Oral LD50 (rats) exceeds 10,000 mg/kg, low toxicity expected at workplace exposure
Inhalation: Irritating to respiratory tract, potential to cause coughing or shortness of breath
Skin/Eye Contact: May cause irritation or allergic reaction in some people
Chronic Effects: Allergic sensitization possible with prolonged exposure
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic according to current research
Target Organs: No data supporting systemic toxicity at occupational levels, may cause immune system response in hypersensitive individuals
Ecotoxicity: Environmental data limited; theoretical risk for aquatic or soil microorganisms; like other antibiotics may contribute to resistance in natural settings
Persistence and Degradability: Expected to degrade slowly under environmental conditions
Bioaccumulation: Limited data; not expected to bioaccumulate significantly
Mobility in Soil: Moderate, may migrate via water run off
Other Adverse Effects: Avoid uncontrolled environmental release, follow guidelines for disposal of pharmaceutical actives
Methods of Disposal: Dispose of unused or waste product in accordance with local and national pharmaceutical waste regulations; never flush down drains
Packaging Disposal: Rinse packaging and dispose of through licensed chemical waste contractor or as instructed by local authorities
Environmental Precautions: Do not allow entry into watercourses, sewers, or soil
Special Precautions: Triple rinse containers prior to recycling or incineration if required
UN Number: Not classified as hazardous for transport by air, road, or sea under ADR, IMDG, IATA regulations
Proper Shipping Name: Not regulated
Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Prevent mechanical damage to containers, avoid moisture ingress during transit
Labelling: Not subject to identification for regulatory purposes under GHS for the supplied grade
Inventory Status: Listed in major chemical inventories if intended for pharmaceutical use
OSHA Status: Not regulated as hazardous substance in standard use
Other Regulations: Subject to drug laws and guidelines for active pharmaceutical ingredients in respective jurisdictions, follow workplace health and safety provisions at national and local level
Risk Phrases: May provoke allergy in susceptible persons
