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Product Name: Cefpodoxime Proxetil Nucleus, 7-Amca, 7-Amino-3-Methoxymethyl-3-Cephem-4-Carboxylic Acid
Chemical Formula: C10H12N4O4S2
Synonyms: 7-ACA derivative, 7-AMCA, Cephalosporin Nucleus, 7-Aminocephalosporanic Acid with methoxymethyl substitution
CAS Number: 80195-14-4
Intended Use: Pharmaceutical intermediate, antibiotic synthesis
Supplier Details: Obtain manufacturer and emergency contact information directly from the procurement documentation for the most current numbers and addresses
Recommended Restrictions: For research and industrial manufacturing. Not for direct human or veterinary use without further processing.
Classification: Category 3 Acute Inhalation Toxicity, Category 2 Eye Irritation, Category 1 Skin Sensitizer
Signal Word: Danger
Hazard Statements: May cause allergic skin reaction. Dust may cause respiratory and eye irritation. Exposure may trigger symptoms in susceptible individuals and those previously sensitized to beta-lactam antibiotics.
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Minimize dust generation and accumulation. Wash hands thoroughly after handling. Use only in a well-ventilated environment. Avoid breathing dust or aerosols. Wear protective gloves, eye and face protection.
Chemical Name: 7-Amino-3-Methoxymethyl-3-Cephem-4-Carboxylic Acid
Concentration: 95-100% (purity range typical for research-use substances)
Impurities: Trace beta-lactam byproducts & synthetic intermediates at less than 1%
Hazardous Components: Ingredient itself, known as a potent beta-lactam sensitizer with well-documented risk of allergic reaction to exposed individuals, especially healthcare workers and those with penicillin allergy history.
Inhalation: Remove from exposure source immediately, move the person to fresh air, seek medical attention if irritation symptoms, coughing, shortness of breath, or asthma-like symptoms develop.
Skin Contact: Wash skin thoroughly with soap and water for at least 15 minutes. Remove contaminated clothing and launder before reuse. If rash or irritation persists or develops later, consult a healthcare provider.
Eye Contact: Rinse with plenty of water, lifting eyelids occasionally, for at least 15 minutes. If redness, pain, or visual changes occur, call an ophthalmologist.
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical professionals. Seek medical attention in the event of accidental ingestion or allergic reactions such as hives, swelling, or difficulty breathing.
Symptoms and Signs: Allergic contact dermatitis, sneezing, conjunctivitis, bronchospasm, restrictive breathing, anaphylaxis, and delayed-onset rashes possible in sensitized individuals.
Note for Physician: Treat symptomatically and provide supportive care. Consider the risk of severe beta-lactam allergy.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, foam, or water spray for large fires.
Unsuitable Extinguishing Media: Do not use water jets, as these may spread powders.
Hazardous Combustion Products: Organic vapors including nitrogen oxides, sulfur oxides, carbon monoxide, and carbon dioxide are possible if the substance decomposes in fire.
Advice for Firefighters: Wear self-contained breathing apparatus and full protective suit to avoid exposure to hazardous fumes. Evacuate area, contain run-off from firefighting to prevent contamination of waterways.
Special Hazards: Dust suspended in air can pose explosion risk under specific conditions; avoid ignition sources.
Personal Protection: Equip responders with chemical-resistant gloves, safety goggles, lab coat, and suitable respiratory protection for dusts.
Environmental Precautions: Prevent bulk material, wash water, or residues from entering drains, surface water, or soil.
Cleanup Methods: Vacuum spill using high-efficiency (HEPA) filter-equipped equipment or sweep gently with minimal dust generation. Place spilled material in clearly labeled chemical waste containers for proper disposal.
Decontamination: After visible removal, clean area with damp cloth or detergent solution, dispose of all cleaning materials in hazardous waste containers.
Handling Precautions: Wear personal protective equipment and avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke in areas where chemical is handled. Use only in controlled areas with appropriate ventilation. Limit exposure to those who have been trained in high-potency pharmaceutical handling.
Storage Conditions: Store in a tightly sealed container, protected from light and moisture. Recommended storage between 2–8°C. Label storage area clearly and limit access to authorized personnel.
Incompatible Materials: Strong oxidizers, acids, and bases. Avoid mixing with reactive substances.
Handling Notes: Maintain traceability of material use, and record disposal by batch; focus on robust hygiene protocols in all handling environments.
Exposure Limits: No occupational exposure limits specifically established for this substance, but consider as a sensitizing agent at low airborne levels.
Engineering Controls: Use local exhaust ventilation, powder containment isolators, or glove boxes to reduce airborne concentrations.
Personal Protective Equipment: Certified chemical-resistant gloves (nitrile or equivalent), splash-proof safety goggles, lab coat or Tyvek suit. For dust-generating work, use an approved particulate respirator (N95 or better). Emergency showers and eyewash stations should remain accessible.
Hygiene Measures: Wash hands and exposed skin thoroughly before eating or drinking. Remove contaminated clothing quickly and launder separately from other laundry.
Physical State: Off-white to slight yellowish crystalline powder
Odor: Slight characteristic odor, low volatility
Melting Point: 208–214°C (decomposition)
Solubility: Slightly soluble in water; more soluble in polar organic solvents such as methanol or dimethyl sulfoxide (DMSO)
pH: Neutral to mildly acidic in aqueous suspension
Boiling Point: Not applicable; decomposes before boiling
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log Pow): Data not established; related cephalopsorins show low-moderate partitioning to organic phase
Density: Approximately 1.4–1.5 g/cm³
Flash Point: Not determined (solid, non-flammable characteristics typical at room temperature)
Stability: Stable under recommended conditions (cool, dry, away from direct light). Decomposes on prolonged exposure to heat, acid, or base.
Reactivity: Incompatible with strong acids, bases, and oxidizing agents. Hydrolysis may occur with excess moisture.
Hazardous Polymerization: Not expected to occur under normal handling.
Decomposition Products: Toxic gases including carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides.
Special Note: Chemically related to beta-lactams; hydrolysis destroys the pharmacologically active beta-lactam ring. Careful consideration needed for expired or degraded material.
Acute Toxicity: Limited animal toxicity data; oral LD50 is greater than 2,000 mg/kg (rat). Considered low acute toxicity, but high hazard for allergic sensitization.
Chronic Toxicity: Prolonged exposure increases risk of developing skin and respiratory sensitization; asthma or severe allergic reactions can result from repeated contact.
Irritation: Contact with eyes or mucosal surfaces may cause irritation. Inhalation of dust may cause sore throat, coughing, or sneezing.
Skin Sensitization: Strong evidence supports beta-lactam antibiotics as potent skin sensitizers, even at trace amounts.
Carcinogenicity: Not classifiable; not identified as carcinogenic by IARC, NTP, or OSHA.
Mutagenicity: No evidence of mutagenicity from standard in vitro tests for the cephalosporin class.
Reproductivity: Data insufficient for definitive conclusions—use with caution and consult material with respect to pregnancy and lactation risk.
Ecotoxicity: Potentially harmful to aquatic organisms even in low concentrations. Antibiotics can disrupt microbial activity in water and soil.
Persistence and Degradability: Partially biodegradable in standard wastewater treatment processes, degradation rate may vary considerably based on environmental conditions.
Bioaccumulation: Significant bioaccumulation unlikely based on low log Pow and ready biodegradability, but persistence of antibiotic activity may present concern.
Mobility in Soil: Moderate soil mobility—parent compound or metabolites may transport in surface runoff after accidental release.
Other Adverse Effects: Proper disposal prevents active pharmaceutical from impacting aquatic and terrestrial systems.
Waste Treatment Methods: Dispose of contents and container as hazardous pharmaceutical waste. Incinerate under controlled conditions at a licensed facility.
Do Not: Discharge to drains, water courses, or environment.
Container Handling: Clean and triple-rinse empty containers prior to disposal or recycling in line with regional requirements. Do not reuse packaging.
Special Instructions: Follow all local, regional, and national hazardous waste management regulations for cephalosporin antibiotics and pharmaceutical intermediates.
UN Number: Not regulated for ground, air, or sea transportation in most jurisdictions if shipped as non-infectious, non-flammable solid
Proper Shipping Name: Chemical substance, solid, not otherwise specified
Transport Hazard Class: Nonhazardous for transport according to IATA, IMDG, and ADR
Packing Group: Not assigned
Special Transport Precautions: Protect package from being crushed or punctured during transport, avoid moisture exposure in transit, secure containers to prevent movement or release in case of breakage.
Emergency Response: In the event of transport-related spillage, follow recommended accidental release protocol, notify proper authorities
Labelling: All containers must display the identity of the material, hazard statements, and recommended precautions. Labelling rules follow national and international guidelines for sensitizing pharmaceutical actives.
Inventories: Registered with most chemical control authorities (REACH, TSCA, AICS) in lists for pharmaceutical intermediates.
OSHA: Considered hazardous under Hazard Communication Standard requirements.
Other Regulations: Compliance with workplace safety, pharmaceutical manufacturing, and worker health monitoring standards applies. Ensure handlers are aware of relevant beta-lactam exposure protocols.
Risk Phrases: R42 may cause sensitization by inhalation. R43 may cause skin sensitization.
