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Product Name: Cefpodoxime Proxetil
Chemical Formula: C21H27N5O9S2
Use: Oral cephalosporin antibiotic for human medicine
Manufacturer: Refer to official packaging for updated contact details
Synonyms: Cefpodoxime; CPD Proxetil
Emergency Contact: Refer to regional poison control or a licensed healthcare provider
CAS Number: 80210-62-4
UN Number: Not regulated by transport authorities
Hazard Class: Harmful if swallowed or inhaled
Target Organs: Liver, kidneys, gastrointestinal system
Eye Contact: May cause irritation, redness, and watering
Inhalation: Potential respiratory tract irritation
Skin Contact: Prolonged exposure could cause allergic reactions; irritation possible
Environmental Effects: Antibiotic contamination can disrupt aquatic environments
GHS Label Elements: Health hazard, exclamation mark
Potential Routes of Exposure: Ingestion, inhalation, skin, or eye contact
Cefpodoxime Proxetil: 98%–100% by weight
Impurities: Below controlled pharmaceutical thresholds
Inactive Components: None—pure active pharmaceutical ingredient
Other Chemical Additives: None
Molecular Weight: 557.6 g/mol
Inhalation: Move individual to fresh air, seek medical attention for breathing difficulty
Skin Contact: Immediately wash affected area with soap and water, remove contaminated clothing
Eye Contact: Rinse gently with plenty of water, lifting eyelids; seek medical help if irritation persists
Ingestion: Rinse mouth, do not induce vomiting; consult physician immediately
Delayed Effects: Allergic reactions, rashes, trouble breathing may occur
Advice for Doctors: Treat symptomatically—no specific antidote available
Suitable Extinguishing Media: Use dry chemical, CO2, foam, or water spray
Hazardous Combustion Products: Emits toxic fumes—nitrogen oxides, sulfur oxides, carbon monoxide
Protective Equipment: Firefighters should wear full gear and self-contained breathing apparatus
Special Firefighting Procedures: Evacuate area, prevent runoff, isolate hazard
Thermal Decomposition: Product may break down releasing hazardous gases above 200°C
Personal Protection: Use gloves, eye protection, and respirators if aerosol/dust forms
Spill Control: Ventilate area, avoid generating dust
Cleanup Method: Sweep or shovel without raising dust, place in properly labeled container
Decontamination: Wash area thoroughly with water and mild detergent
Environmental Precautions: Avoid runoff into drains, prevent soil and water contamination
Handling: Employ good industrial hygiene—wear PPE, avoid direct contact
Avoid: Inhalation of dust, contact with skin, eyes, and clothing
Hygiene: Wash hands before eating, drinking, or smoking
Storage Conditions: Cool, dry, well-ventilated area; keep containers tightly closed
Incompatible Materials: Strong oxidizing agents, acids, alkaline substances
Shelf Life: Follow manufacturer recommendations for temperature and humidity
Engineering Controls: Use local exhaust ventilation to minimize exposure
Personal Protective Equipment: Gloves (nitrile), safety goggles, laboratory coat
Respiratory Protection: NIOSH-approved particulate respirator for dusty environments
Occupational Exposure Limits: No specific threshold limit value established
Environmental Protection: Keep pharmaceuticals out of wastewater and landfills wherever possible
Appearance: White to off-white crystalline powder
Odor: Odorless or faint medicinal smell
pH (suspension): 4.0–6.0 (in water)
Boiling Point: Decomposes before boiling
Melting Point: 108–110°C (decomposes)
Flash Point: Not applicable
Solubility: Poorly soluble in water, soluble in methanol and dimethyl sulfoxide
Partition Coefficient: log P (octanol/water): –0.6
Vapor Pressure: Negligible at room temperature
Density: Approx. 1.5 g/cm3
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions under normal use
Incompatible Substances: Strong oxidants, acids, alkalis
Decomposition Products: Hazardous gases—carbon monoxide, nitrogen oxides, sulfur oxides
Polymerization: Product will not undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat): > 5,000 mg/kg
Chronic Effects: Possible liver and kidney changes at high exposure
Carcinogenicity: No evidence from available animal studies
Mutagenicity: Negative in strains tested for gene mutation
Reproductive Toxicity: No teratogenic effects observed in animal tests; limited human data
Sensitization: Allergic skin and respiratory reactions can develop in susceptible people
Symptoms of Exposure: Rash, gastrointestinal upset, allergic response
Ecotoxicity: Antibiotics harm micro-organisms in soil and freshwater
Aquatic Toxicity: Low concentrations can affect aquatic life, algae, and invertebrates
Persistence and Degradability: Product resists breakdown; may persist in water and soil
Bioaccumulation Potential: Not expected due to low log P
Mobility in Soil: Moderate, potential to leach if not properly contained
Effects on Sewage Treatment: Considered hazardous for microbial digestion; do not discard in drains
Waste Disposal Methods: Treat pharmaceutically as hazardous waste
Incineration: Authorized facilities only
Avoid: Discharge to natural waters or municipal landfill
Packaging Disposal: Triple-rinse and puncture before recycling or disposal
Regulatory Requirements: Follow local, regional, and national requirements for disposal
UN Number: Not regulated
IMDG: Not classified as dangerous for transport
ICAO/IATA: Not listed as hazardous cargo
Packaging: Leak-proof, secure, and clearly labeled containers
Special Transport Precautions: Prevent physical damage, maintain proper temperature during transit
U.S. Regulations: Not regulated as a hazardous chemical under OSHA; FDA-approved for specific uses
EU Regulations: Substance considered potentially harmful; subject to REACH guidelines
International Inventories: Listed in WHO and banned substance registries for veterinary use in food animals
SARA Title III: Not listed
Other Specific Regulations: Monitor antibiotic discharge into the environment—some locations have stricter rules
Workplace Labels: Ensure clear hazard communication in labs, pharmacies, or production settings
