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Product Name: Cefodizime Sodium
Chemical Name: Sodium (6R,7R)-7-[(2Z)-2- (2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(R)-2-(5-methyl-1,3,4-thiadiazol-2-ylthio)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS Number: 92396-89-9
Synonyms: Cefodizime Sodium Salt
Recommended Use: Antibiotic for pharmaceutical manufacturing and laboratory research
Supplier Details: [Company Name], [Street Address], [City, State], [Country], [Phone Number], [Email]
Classification (GHS): Not listed as hazardous by GHS, considered a pharmaceutical intermediate
Routes of Exposure: Skin contact, eye contact, inhalation, ingestion
Potential Health Effects: Can trigger allergic reactions, rashes, respiratory tract irritation, and headache with improper handling; ingestion may upset gastrointestinal function
Signal Word: Warning
Pictograms: No GHS pictograms assigned
Chemical Name: Cefodizime Sodium
Concentration: >98%
Impurities: Trace levels of other cephalosporin-related compounds below 2%
Other Ingredients: No additives or preservatives
Inhalation: Move exposed individual to fresh air; seek medical assistance for any breathing difficulties or persistent symptoms
Skin Contact: Remove contaminated clothing; wash skin immediately with soap and plenty of water for at least fifteen minutes, especially after direct exposure
Eye Contact: Rinse cautiously with water for several minutes, lifting upper and lower eyelids; remove contact lenses if present and easy, continue rinsing
Ingestion: Rinse mouth thoroughly; seek medical attention if discomfort persists or symptoms appear
Indications for Medical Attention: Allergic reactions, difficulty breathing, or any serious symptoms warrant prompt healthcare provider evaluation
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, or water spray based on surrounding fire
Unsuitable Extinguishing Media: High-volume water jet for product fires due to risk of product contamination
Specific Hazards: Combustion may emit carbon monoxide, sulfur oxides, and nitrogen oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective gear to avoid inhaling fumes
Personal Precautions: Evacuate non-essential personnel; use proper protective clothing (gloves, lab coat, goggles, NIOSH-approved respirator)
Spill Cleanup: Avoid dust formation; ventilate area; collect spilled material using slightly damp absorbent cloth or inert materials such as dry sand for larger amounts; dispose of in compliance with local regulations
Environmental Precautions: Prevent entry into drains, surface waters, or soil to safeguard water sources and natural habitats
Handling Practices: Avoid generating dust, breathing vapors, or prolonged skin and eye contact; wear protective equipment at all times during handling
Hygiene Practices: Wash hands thoroughly before eating, drinking, or using restroom; remove contaminated apparel and clean separately
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated area; keep away from strong oxidizers, moisture, and sunlight; recommended storage temperature is 2–8°C, protected from freezing
Exposure Limits: Not established for Cefodizime Sodium
Engineering Controls: Use appropriate laboratory fume hoods or clean benches if dust or aerosols arise
Eye/Face Protection: Safety glasses or goggles with side shields
Skin Protection: Laboratory gloves (nitrile, latex, or equivalent), lab coat, and closed-toe shoes
Respiratory Protection: Dust/mist respirator for operations with risk of inhalable aerosols, particularly when handling bulk material
Work Practice Controls: Avoid direct handling, use automated systems or local exhaust
Appearance: White to slightly yellowish powder
Odor: Characteristic, faint
Melting Point: Not specified; decomposes before melting
Boiling Point: Decomposes; not applicable
Solubility: Freely soluble in water; barely soluble in methanol, insoluble in acetone, ether, and chloroform
pH: Typically 4.0–6.0 (in aqueous solution)
Vapor Pressure: Not measurable, solid substance
Density: Approx. 1.7 g/cm³
Partition Coefficient: Not available
Flash Point: Not flammable under normal conditions
Chemical Stability: Stable if kept in original packaging under recommended storage, though light and moisture may increase degradation
Conditions to Avoid: Exposure to moisture, high humidity, open air, very high temperatures, and strong light
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition Products: May release toxic sulfur and nitrogen compounds upon decomposition
Acute Toxicity: Low acute toxicity by oral, dermal, or inhalation routes for laboratory animals
Chronic Effects: Repeated contact may sensitize skin, leading to rashes or allergic responses
Target Organs: Prolonged exposure may affect kidneys or immune system due to its cephalosporin structure
Carcinogenicity: Not classed as a carcinogen under IARC, NTP, or OSHA
Mutagenicity: No reliable evidence for genotoxicity up to this date
Reproductive Toxicity: No strong risk noted in standard animal screening
Ecotoxicity: Data is limited, but may disturb microbial populations and aquatic organisms if released in significant concentrations
Persistence and Degradability: Expected to undergo slow biodegradation; stays persistent in aquatic environments if not properly deactivated
Bioaccumulative Potential: Low, due to water solubility and moderate molecular weight
Mobility in Soil: Likely mobile in water, with potential to reach groundwater through porous substrates
Waste Methods: Dispose unused material as hazardous pharmaceutical waste through certified contractor; do not dump into drains or natural bodies of water
Contaminated Packaging: Triple-rinse empty containers, puncture, and discard as hazardous waste
Local Disposal Laws: Follow local, state, and national regulations; incineration recommended for complete destruction under approved conditions
UN Number: Not classified as dangerous for transport under ADR/RID, IMDG, or IATA
Transport Hazards: Non-hazardous for air, sea, or road shipment
Handling During Transport: Keep packaging tightly closed and protected from physical damage, moisture, and high temperature
Special Precautions: Mark as “Pharmaceutical Intermediate – Not for Human Use” during transit to avoid misidentification
Regulations: Listed under pharmaceutical substances but not controlled or scheduled according to international conventions
US TSCA Inventory: Not listed
European Regulations: Not classified as hazardous under REACH, not subject to SVHC listing
Labelling: No hazard statements required under GHS, though prudent use demands maintaining full records and reporting spills
Other National Inventories: Consult regional chemical inventory requirements prior to import, export, or commercial manufacturing
