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Product Name: Cefmetazole Sodium
Chemical Name: Cefmetazole Sodium Salt
Synonyms: Cefmetazole sodium hydrate, CMZ-Na
Molecular Formula: C15H14N8NaO5S3
Molecular Weight: 528.51 g/mol
CAS Number: 56796-39-5
Intended Use: Pharmaceutical raw material, antibiotic intermediate, research and laboratory applications
Manufacturer Contact: Refer to product label for emergency phone number, supplier details, and address
Emergency Phone: Provided on shipping documents and MSDS cover page for immediate hazards
Recommended Use Restrictions: Do not use outside of intended applications prescribed by technical or medical professionals
Hazard Class: Not classified as hazardous according to GHS for most uses, but may cause irritation and sensitization in some individuals
Signal Word: None required by major frameworks, but caution advised due to possible health concerns
Hazard Statements: Possible allergen, mild irritation to eyes and skin, may cause respiratory discomfort if inhaled as powder
Pictogram: No GHS pictograms required
Precautionary Measures: Avoid inhalation, ingestion, direct skin or eye contact; use standard laboratory precautions
NFPA (Fire, Health, Reactivity): Health: 1, Flammability: 0, Reactivity: 0
Active Ingredient: Cefmetazole Sodium
Purity: Typically >97% pharmaceutical grade
Impurities: May contain trace amounts of related substances (specific impurity limits set by pharmacopeia, generally below 1.0%)
Additives/Fillers: None in pure active powder; reconstituted solutions may contain excipients specified by the preparing pharmacist
Ingredient Listing: Cefmetazole Sodium only (no hazardous fillers present)
Inhalation: Move affected person to fresh air immediately; seek medical attention if symptoms like coughing or shortness of breath develop
Skin Contact: Wash affected area with plenty of water and soap; remove any contaminated clothing
Eye Contact: Rinse open eyes with running water for several minutes, lifting eyelids to ensure thoroughness; seek prompt attention if irritation persists
Ingestion: Rinse mouth thoroughly; never attempt to induce vomiting; seek emergency care if large quantities swallowed or symptoms occur
Most Important Symptoms and Effects: Allergic reactions, rashes, respiratory irritation possible for sensitive individuals
Suitable Extinguishing Media: Use media appropriate for surrounding fire (water spray, dry chemical, CO2, foam)
Unsuitable Extinguishing Media: Avoid direct water jet on burning powder
Special Hazards: Decomposes upon heating, releasing sulfur oxides and nitrogen oxides; dust may form explosive mixtures in air
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and standard firefighting clothing to avoid inhalation of fumes
Advice for Firefighters: Move containers away from fire area if safe; control water runoff to prevent environmental contamination
Personal Precautions: Avoid dust formation; wear safety goggles, gloves, and lab coat
Emergency Procedures: Ventilate area and evacuate unnecessary personnel
Environmental Precautions: Prevent from entering drains, surface, or groundwater
Methods for Clean-Up: Collect spillage carefully using non-sparking tools; transfer to a clearly labeled waste container; clean area with damp paper towel
Disposal: Dispose of according to local and national regulations for pharmaceutical waste
Reporting Requirements: Notify safety coordinator or supervisor for larger spills
Handling: Use containment tools to avoid loose powder; minimize dust generation; always handle with appropriate PPE
Hygiene Practices: Wash hands thoroughly after handling; avoid eating, drinking, or smoking in work area
Storage Conditions: Store in airtight container, at 2-8°C unless otherwise specified by label; keep away from moisture, incompatible materials and direct sunlight
Incompatibilities: Avoid strong oxidizing agents, extreme heat; instability increases in humid or unsealed conditions
Storage Containers: Use tightly sealed, compatible glass or HDPE containers
Labeling: Ensure clear labeling with content, hazard, batch number, and expiry date
Occupational Exposure Limits: No established OSHA PEL, ACGIH TLV, or EU limits; minimize exposure as pharmaceutical active
Engineering Controls: Use chemical fume hoods or well-ventilated workspaces; apply local exhaust ventilation for weighing and sampling
Personal Protective Equipment (PPE): Safety goggles, laboratory gloves (nitrile recommended), disposable lab coat, dust mask or NIOSH-approved respirator for powder handling
Hygiene Measures: Change gloves frequently; avoid hand-to-face contact; wash after handling
Environmental Exposure Controls: Avoid release to drains or environment, contain at source
Appearance: Off-white to pale yellow crystalline powder
Odor: Odorless to faint drug-like smell
pH: 4.0–6.0 (1% solution)
Boiling Point: Not applicable; decomposes before boiling
Melting Point: 180–185°C (with decomposition)
Solubility: Freely soluble in water, slightly soluble in alcohol
Vapor Pressure: Negligible, non-volatile solid
Partition Coefficient (Log Pow): Not significantly lipophilic (log P expected below 0)
Flash Point: Not flammable under normal conditions
Explosive Properties: Dust may pose explosion risk in poorly ventilated areas
Chemical Stability: Stable in dry, sealed conditions; sensitive to moisture and heat
Possibility of Hazardous Reactions: No dangerous reactions under recommended use; hazardous decomposition possible at high temperatures
Conditions to Avoid: Excessive heat, humidity, open containers
Incompatible Materials: Strong oxidizing agents, acids
Decomposition Products: Nitrogen oxides, sulfur oxides, carbon oxides, sodium compounds
Acute Toxicity: LD50 (oral, rat): >2000 mg/kg; considered low toxicity, but not intended for oral consumption in humans unless under physician care
Irritation and Corrosivity: Mild irritant to eyes and skin; inhalation may cause respiratory discomfort
Allergenic Potential: Documented cases of hypersensitivity in exposed workers or patients; serious allergic reactions possible in sensitive persons
Chronic Exposure: No known long-term carcinogenic, mutagenic, or reproductive risks identified in available studies
Symptoms of Exposure: Rash, itching, shortness of breath, respiratory irritation, headache in rare cases
Target Organs: Skin, eyes, respiratory tract
Ecotoxicity: Cefmetazole shows moderate toxicity towards aquatic organisms; exact LC50 (fish) >100 mg/L; caution warranted with water discharge
Persistence and Degradability: Undergoes slow biodegradation; not readily eliminated in wastewater treatment
Bioaccumulative Potential: Low, due to high solubility and polar structure
Mobility in Soil: Expected to be highly mobile; may leach into groundwater if released
Other Adverse Effects: Large-scale contamination could disrupt aquatic microbial life; pharmaceutical residues monitored in several regions
Waste Disposal Methods: Small laboratory amounts may be incinerated in approved chemical disposal facility; pharmaceutical waste contractor for bulk material
Container Disposal: Triple-rinse, deface label, and dispose as pharmaceutical waste
Environmental Precautions: Avoid disposal in household drains, sewage, or natural water bodies; follow local regulatory requirements strictly
Regulatory Classification: May qualify as hazardous chemical waste due to antibiotic activity
UN Number: Not regulated as dangerous good for transport via ADR/RID/IMDG/IATA
Proper Shipping Name: Cefmetazole Sodium
Transport Hazard Class: Not assigned
Packing Group: Not assigned; normal packaging sufficient for routine transit
Special Precautions: Avoid temperature extremes, moisture ingress, and rough handling; ship in sealed, labeled containers
Bulk Transport: Not recommended except under controlled conditions
Labelling: Not classified as hazardous under US OSHA, EU CLP, or GHS, though safe handling measures still required
Chemical Inventory Status: Listed in relevant pharmacopeias, major chemical registries (such as EINECS, TSCA: see supplier for confirmation)
OSHA HazCom: Not classified as hazardous, but handle under pharmaceutical control measures
REACH Compliance: Meets REACH exemption criteria for medicinal products; consult local EU importer for details
Other Regulations: Not a controlled substance; observe local workplace safety rules for pharmaceutical actives
Workplace Monitoring: Best practice recommends exposure monitoring in bulk-handling or formulation plants
