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Product Name: Cefdinir Active New Ester
Chemical Name: 7-[2-(2-Amino-4-thiazolyl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylic acid, New Ester Form
CAS Number: 91832-40-5
Recommended Use: Pharmaceutical intermediate used in antibiotic formulation
Supplier: Manufacturer Contact Information Available Upon Request
Emergency Telephone: Provided by Manufacturer
Storage Conditions: Store below -20°C, protected from light and moisture to avoid degradation and loss of potency
Classification: Skin irritant, Eye irritant, Sensitizer, Potential respiratory irritant
Label Elements: Hazard pictograms: Exclamation mark (irritant/skin sensitizer), Health hazard (respiratory/organ effects)
Signal Word: Warning
Hazard Statements: Causes irritation to skin and eyes. May cause allergic reactions. Prolonged inhalation affects respiratory system.
Precautionary Statements: Wear protective gear. Avoid inhalation and contact with skin and eyes. Handle under well-ventilated conditions.
Cefdinir Active New Ester: ~98%
Minor Impurities: Estimated ≤2% (process-related intermediates, no solvents retained under low temperature storage)
Hazardous Components: No additional hazardous substances anticipated at storage temperature; free from known carcinogens by process design
Molecular Formula: C14H13N5O5S2
Molecular Weight: 395.41 g/mol
Inhalation: Move affected person into fresh air immediately. Seek medical attention for persistent symptoms such as coughing or respiratory discomfort.
Skin Contact: Wash area thoroughly with plenty of water and soap. Remove contaminated clothing. Get medical advice if irritation develops.
Eye Contact: Rinse gently under running water for 15 minutes, holding eyelids open. Seek ophthalmic guidance for persistent redness or pain.
Ingestion: Do not induce vomiting. Rinse mouth with water. Get medical assistance—bring product information if possible.
Note to Physician: Treat symptomatically, monitor for allergic reaction and support respiration if necessary.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Special Hazards: May emit nitrogen oxides, sulfur oxides, carbon monoxide, and other toxic vapors during decomposition
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Additional Precautions: Evacuate area, cool exposed containers with water spray, and prevent runoff from entering drains
Personal Precautions: Wear protective coveralls, gloves, and safety goggles. Avoid dust formation, ventilate area well
Environmental Precautions: Prevent spillage from entering soil, sewage, or waterways; alert authorities if contamination occurs
Cleanup Methods: Collect with inert absorbent, sweep up without raising dust, place in sealed container for disposal according to local, regional, and national guidelines
Decontamination: Wash tools and surfaces with soap and water after removal. Dispose of washes as chemical waste
Handling: Avoid direct contact or inhalation; use in fume hood or well-ventilated area. Maintain good industrial hygiene; keep containers tightly closed
Storage: Store at low temperature (≤ -20°C), protect from light, store in clearly labeled, airtight, and moisture-proof containers. Avoid repeated freeze-thaw cycles to preserve product integrity
Incompatibility: Strong acids, strong oxidizing agents, strong bases—contact may lead to reaction and degradation
Engineering Controls: Use local exhaust ventilation or process enclosures
Occupational Exposure Limits: No established threshold limit; practice careful handling and minimize exposure
Engineering Controls: Fume hood, local exhaust, routine monitoring of air for dust and vapor levels
Personal Protective Equipment: Impermeable gloves (nitrile or PVC), full laboratory coat, eye protection (chemical goggles), face shield if risk of splash present
Respiratory Protection: Use dust mask or NIOSH-approved respirator if occupational exposure risk exists
Hygiene Considerations: Avoid eating, drinking, or smoking during use; wash hands thoroughly after handling
Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Solubility: Sparingly soluble in water, soluble in methanol and dimethyl sulfoxide
Melting Point: ~197°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at ambient conditions
pH: Not applicable (will vary slightly with solvent)
Partition Coefficient: Data not available
Flash Point: Not flammable in powdered form under low temperature
Chemical Stability: Stable under recommended storage; decomposition accelerated by heat, light, moisture
Reactivity: Reacts with strong acids, bases, and oxidizers; avoid contact to prevent hazardous decomposition
Decomposition Products: Nitrogen oxides, sulfur oxides, organic fragments
Polymerization: No hazardous polymerization
Special Sensitivities: Prone to hydrolysis—keep dry
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral and dermal LD50 data not established due to limited testing on humans; animal studies indicate moderate toxicity with potential for allergic reaction
Chronic Effects: Prolonged exposure may result in sensitization, allergic dermatitis, possible liver and kidney effects in susceptible individuals
Symptoms: Irritation of skin, eyes, and respiratory tract; potential gastrointestinal upset if ingested
Carcinogenicity: Not listed as known or suspected carcinogen by IARC, NTP, or OSHA
Mutagenicity/Reproductive Toxicity: No evidence found under recommended use and storage conditions
Ecotoxicity: Potential toxicity to aquatic organisms—avoid release into environment
Persistence and Degradability: Not readily biodegradable, may persist in soil and water over time
Bioaccumulation Potential: Data suggest low bioaccumulation, but avoidance of environmental discharge is prudent
Mobility in Soil: Limited data; low mobility expected when handled properly
Other Adverse Effects: Antibiotic properties may disrupt microbial community balance in natural water systems
Waste Treatment Methods: Dispose of as hazardous pharmaceutical waste according to local, state, and national regulations
Container Handling: Empty containers retain product residue—handle as hazardous. Triple rinse, destroy labels, and puncture before discarding.
Recommended Disposal: Incineration in approved chemical waste facility is preferred; avoid landfill disposal if incineration unavailable
Additional Guidance: Do not mix with other waste streams. Document disposal procedures for compliance auditing
UN Number: Not regulated for transport under current IATA, IMDG, or ADR recommendations when shipped at low temperature for laboratory/research quantities
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Special Precautions: Keep sealed, maintain cold chain throughout transport, provide documentation indicating product properties and emergency guidance
Marine Pollutant: No mandatory marking, but avoid accidental release during shipment
US Federal Regulations: Not listed under SARA 302/304/313, CERCLA, or TSCA
EU REACH Status: Intermediate for pharmaceutical use; not subject to registration for certain research and development activities
Labeling Requirements: Adhere to GHS (Globally Harmonized System) for workplace labeling and hazard communication
Workplace Control: Regulated by OSHA Hazard Communication Standard; safety data available to employees upon request
National Inventory Listings: Check with supplier for up-to-date inclusion
Other Applicable Laws: Subject to transport, workplace safety, and chemical hygiene plans as required by site jurisdiction
