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Product Name: Cefcapene Precursor Acid
Chemical Name: (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2-[(Z)-methoxyimino]acetamido]-3-cephem-4-carboxylic acid
Synonyms: Intermediate for Cefcapene Synthesis
Manufacturer: [Company name and address required]
Emergency Contact: [Phone number required, recommend local or company-specific]
Recommended Use: Active pharmaceutical intermediate, laboratory chemical; use under guidance of qualified professionals.
CAS Number: [Insert specific CAS Number if available]
Globally Harmonized System (GHS) Classification: Eye Irritant (Category 2), Skin Sensitizer (Category 1), Respiratory Sensitizer (Category 1)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, may cause allergic skin reaction, harmful if swallowed or inhaled, may damage kidneys through prolonged exposure.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid all unnecessary exposure. Wear protective gloves and eye/face protection. Do not breathe dust or fumes. Wash thoroughly after handling.
Cefcapene Precursor Acid: 95-99%
Other Intermediates or Byproducts: Less than 5%, proprietary or process-related impurities
Stabilizers or Additives: None intentionally added
Impurity Profile: Potential for trace organic solvents, minor degradation products; characterization required for each batch.
Inhalation: Move to fresh air immediately. Keep patient comfortable. Seek medical attention for persistent symptoms or if respiratory issues develop.
Skin Contact: Remove contaminated clothing. Wash thoroughly with mild soap and water. Use emollients for irritation. Medical attention recommended if rash or persistent irritation develops.
Eye Contact: Rinse cautiously with plenty of water, lifting eyelids as needed. Continue for at least fifteen minutes. Emergency medical attention needed for redness, pain, or vision impairment.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Drink small amounts of water only if fully conscious. Seek immediate medical help.
Most Critical Symptoms: Respiratory sensitivity, skin rash, eye damage, allergic reactions, gastrointestinal upset.
Advice for Doctor: Symptomatic treatment; consider antihistamines or corticosteroids for allergic reaction.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide.
Special Hazards: Combustion releases hazardous gases, including nitrogen oxides, sulfur oxides, and carbon monoxide.
Protective Equipment: Wear full protective gear and self-contained breathing apparatus. Use fully enclosed suits in case of large-scale fire.
Fire-Fighting Instructions: Remove containers from risk area if safe. Cool containers with water spray to prevent rupture. Avoid inhaling smoke, fumes, or dust.
Personal Protection: Wear disposable gloves, lab coat, chemical safety goggles, and suitable respiratory protection.
Environmental Precautions: Prevent undiluted material from entering water courses or soil. Avoid contamination of public sewage systems.
Containment Methods: Sweep up spilled powder gently to avoid dust generation. Use non-sparking tools. Keep containers sealed after cleanup.
Cleaning Procedures: Collect residues with damp towel or absorbent pad. Dispose of according to local regulations. Ventilate all affected areas thoroughly.
Handling Precautions: Use only in properly ventilated areas. Avoid dust formation and prevent physical contact with product. Handle as if toxic and allergenic.
Hygiene Recommendations: Do not eat, drink, or smoke during use. Wash hands and face before breaks and after handling.
Storage Conditions: Store in tightly closed containers, in a cool, dry, well-ventilated space. Protect from heat, light, moisture, and incompatible chemicals.
Temperature Range: Recommended storage temperature between 2°C and 8°C.
Segregation: Keep away from oxidizers, acids, and reducing agents.
Engineering Controls: Ensure effective local exhaust ventilation in workspaces; use chemical fume hoods for open handling.
Personal Protective Equipment (PPE):
- Body protection: laboratory coat or coverall
- Eye protection: safety goggles with side shields
- Hand protection: chemical-resistant gloves (nitrile or neoprene suggested)
- Respiratory protection: N95 or P3 respirator, especially for powders or insufficient ventilation
Environmental Controls: Use closed systems or secondary containment for transfers. Implement spill containment measures.
Appearance: White to off-white crystalline powder
Odor: Slight or none
Odor Threshold: Not established
pH (solution): 3.0–4.5 at 10 mg/mL in water
Melting Point: 190–210°C (decomposition suspected above 210°C)
Solubility: Freely soluble in water, slightly soluble in methanol, insoluble in non-polar solvents
Vapor Pressure: Not applicable (solid)
Relative Density: 1.37–1.41 (calculated, not measured)
Partition Coefficient (log Kow): Data not available
Viscosity: Not applicable
Flash Point: Not flammable in standard conditions
Auto-ignition Temperature: Not self-igniting
Explosive Properties: Not expected under normal storage and use
Oxidizing Properties: Not an oxidizer
Decomposition Products: Nitrogen oxides, sulfur oxides under thermal stress
Chemical Stability: Stable under normal temperature and storage conditions.
Reactivity: May react with strong oxidizers or acids.
Conditions to Avoid: Excessive heat, humidity, direct sunlight, and exposure to open air.
Hazardous Decomposition Products: Nitrogen oxides, sulfur dioxide, carbon monoxide upon decomposition.
Polymerization: Not expected under recommended conditions.
Incompatibilities: Strong bases, strong reducing agents, mineral acids.
Acute Toxicity: Data are limited; expected oral LD50 in rats > 2000 mg/kg based on structural analogy to cephalosporin intermediates.
Routes of Exposure: Inhalation, ingestion, skin and eye contact; all can cause adverse effects.
Skin Sensitization: Sensitizer; known to trigger immune reactions, especially in individuals sensitized to beta-lactam antibiotics.
Respiratory Sensitization: Fine dust may cause asthma-like symptoms or exacerbate existing conditions.
Eye Damage/Irritation: Dust causes ocular irritation, redness, watering, possible damage to corneal tissue after prolonged exposure.
Chronic Effects: Repeated or prolonged exposure may impact kidneys or immune system. Allergic reactions more common in individuals with similar sensitivities.
Carcinogenicity/Mutagenicity: Not known to be carcinogenic. No mutagenicity data available but caution indicated due to beta-lactam structure.
Reproductive Toxicity: Not determined, recommended to avoid exposure during pregnancy.
Aquatic Toxicity: May be hazardous in large quantities to aquatic life due to persistence and bioactivity of beta-lactam structure.
Persistence and Degradability: Moderate; susceptible to hydrolysis under certain conditions, byproducts formed.
Bioaccumulative Potential: Low predicted, based on water solubility and chemical nature.
Mobility in Soil: Moderate–high mobility due to solubility in water; may leach through soil.
Other Adverse Effects: Dispose of carefully; residues may promote antimicrobial resistance in natural environments.
Waste Treatment Methods: Dispose of via incineration or chemical destruction where permitted. Avoid landfill disposal.
Contaminated Packaging: Empty containers should be triple-rinsed and offered for recycling or reconditioning. Follow regulatory requirements.
Precautions: Do not regroup unused chemical with household waste. Do not flush large amounts into wastewater systems.
Hazardous Waste Status: Classified as hazardous waste due to toxicological properties; handle in accordance with national/local regulation.
UN Number: Not classified for transport under most international regulations (verify with local standards).
Proper Shipping Name: Research chemical, not otherwise specified.
Transport Hazard Class: Not regulated; treat as hazardous for all practical purposes.
Packing Group: Not assigned.
Environmental Hazards: Not designated as marine pollutant.
Special Precautions: Ensure containers are tightly sealed, cushioned to avoid breakage, clearly labeled with hazard indication.
GHS Compliance: Meets recommendations for workplace chemical safety labeling and handling.
US TSCA: Not listed for general commercial use; research and pharmaceutical use only.
EU REACH: Intermediate in controlled supply chain; use only by trained professionals.
Worker Protection: Follow occupational hygiene and exposure limits set by OSHA, EU, or local authorities.
Other regulations: Not classified under other international chemical restrictions, but professional chemical safety assessment recommended prior to large-scale use.
