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Product Name: Cefazolinic Acid
Chemical Formula: C14H14N8O4S3
Synonyms: Cefazolin acid, Cephazolinic acid
Recommended Use: Pharmaceutical synthesis, antibiotic intermediate
Manufacturer Details: Supplied by pharmaceutical ingredient producers; full contact details included on shipping documents
Emergency Contact: Emergency response available via local poison control or manufacturer emergency number
CAS Number: 25953-19-9
GHS Classification: Not classified as hazardous under standard GHS criteria, but can cause moderate irritation with extended exposure
Signal Word: Warning
Hazard Statements: Dust may cause eye and skin irritation, mild respiratory discomfort upon inhalation; not proven to be carcinogenic in humans
Precautionary Statements: Avoid contact with eyes and skin, prevent inhalation of dust
Potential Health Effects: Eyes—redness, itching; Skin—irritation, redness, itching; Inhalation—dry cough, mild throat irritation; Ingestion—nausea, gastrointestinal upset if large amounts consumed
NFPA Ratings: Health: 2, Flammability: 0, Reactivity: 0
Main Ingredient: Cefazolinic Acid – Purity greater than 98%
Impurities: Less than 1% by weight, proprietary or pharmacopoeia-standard by-products
Form: Fine white to off-white crystalline powder
Other hazardous ingredients: Product does not include other hazardous components at concentrations above reporting thresholds
Inhalation: Move person to fresh air immediately; seek medical attention if symptoms develop
Eye Contact: Rinse eyes kept open for several minutes under running water; urgent medical attention not typically necessary except for persistent irritation
Skin Contact: Wash with mild soap and running water; remove contaminated clothing
Ingestion: Rinse mouth with plenty of water; call a physician for large or deliberate ingestion
Most Important Symptoms: Mild mucous membrane irritation, possible allergic reaction in sensitive individuals
Suitable Extinguishing Media: Use water spray, carbon dioxide, foam, or dry chemical powder
Unsuitable Extinguishing Media: Avoid direct streams of water as powder may disperse
Special Hazards from Combustion: Releases carbon oxides, sulfur oxides, nitrogen oxides if burned
Fire-Fighter Precautions: Wear full protective gear and self-contained breathing apparatus
Explosion Risk: Dust cloud may produce combustible conditions in enclosed spaces, but risk is very low in normal storage conditions
Personal Precautions: Avoid inhalation and contact with skin or eyes; use recommended personal protection
Environmental Precautions: Prevent entry into drains, sewers, or natural water sources
Methods for Clean-up: Collect spilled powder with a low-sparking tool and place in suitable labeled waste containers; ventilate spill area; wash area with soap and water after cleanup completed
Safe Handling: Work in well-ventilated space; avoid generating dust; do not eat, drink, or smoke while handling
Storage Conditions: Store sealed in original container at controlled room temperature (15–30°C), away from direct sunlight and incompatible materials like strong acids, bases, and oxidizers
Shelf Life: Typically two to three years under recommended storage conditions; check manufacturer's guidance
Incompatibilities: Strong oxidizing agents, reducing agents, heavy metals
Engineering Controls: Local exhaust ventilation or fume hood
Exposure Limits: No established ACGIH, OSHA or NIOSH limits for active ingredient; general nuisance dust limit of 10 mg/m³ recommended
Personal Protective Equipment: Safety glasses with side shields, laboratory gloves, long-sleeved clothing
Respirator Protection: Dust mask approved for particulates if respiratory sensitization risk exists
Hygiene Measures: Wash hands thoroughly after handling and before eating or drinking
Appearance: White to off-white crystalline powder
Odor: Odorless or very faint medicinal smell
pH (1% solution): 4.5 to 6.0
Melting Point/Range: Decomposes above 200°C
Solubility: Slightly soluble in water, insoluble in organic solvents like chloroform and ether
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient: Not available
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to high temperatures, direct sunlight, moisture
Incompatible Materials: Strong acids and bases, strong oxidizing substances
Hazardous Decomposition: Heat can produce sulfur oxides, nitrogen oxides, and carbon oxides
Polymerization: Not known to occur under normal conditions
Routes of Entry: Inhalation, ingestion, skin, eyes
Acute Toxicity: Low toxicity expected from small accidental exposures; exact LD50 in mammals not publicly documented
Chronic Effects: May cause allergic reactions in sensitive or previously sensitized workers
Carcinogenicity: Not listed by IARC, NTP, OSHA as carcinogenic
Other Health Hazards: Repeated or excessive exposure might sensitize some individuals, especially those with a history of allergies to beta-lactam antibiotics
Aquatic Toxicity: Limited data available; as a class, cephalosporin acids degrade over time, but direct discharge into water ecosystems could impact microbial populations
Persistence and Degradability: Biodegrades slowly in soil and water; should not be released uncontrolled
Bioaccumulation: No evidence of bioaccumulation; chemical does not persist in tissues
Mobility in Soil: Low mobility, binds to organic material
Other Adverse Effects: Still best practice to avoid release into waterways due to possible antimicrobial effects on beneficial microflora
Waste Disposal: Dispose in accordance with local, regional, and national regulations; incineration in approved facility preferred
Container Disposal: Triple-rinse and puncture containers; recycle or dispose as chemical waste
Precautions: Do not allow product or runoff to contaminate soil, groundwater, or surface water
UN Number: Not regulated for ground, air, or sea transport
Proper Shipping Name: Not restricted
Transport Hazard Class: Not classified as hazardous
Packing Group: Not assigned
Special Transport Notes: Keep container tightly closed in transit; protect from moisture
Labeling: Complies with requirements for Schedule for pharmaceutical ingredients—avoid misuse
TSCA: Not listed
DSL Status (Canada): Not listed
EU Regulations: Not included as hazardous under current EU chemical guidelines
Workplace Regulations: Standard industrial hygiene rules apply
Other Restrictions: For professional or industrial use only; not for direct consumer sale unless incorporated into finished pharmaceuticals
