© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Cefazolin Sodium
Common Names: Cefazolin sodium for injection, Ancef, Kefzol
Chemical Formula: C14H13N8NaO4S3
Recommended Use: Pharmaceutical antibiotic, treatment of bacterial infections
CAS Number: 27164-46-1
Manufacturer: Multiple sources, including major pharmaceutical companies
Emergency Contacts: Local poison control center, company emergency phone line
Hazard Class: Not classified as hazardous by GHS
Physical Hazards: May form dust, can create respiratory irritation
Health Hazards: May trigger allergic reactions, especially in penicillin-sensitive individuals; eye and skin irritation possible on contact
Environmental Hazards: Expected to have low aquatic hazard; large spills may disrupt wastewater treatment processes
Signal Words: Warning (specific to individuals with known allergies)
Pictograms: None mandated, but “exclamation mark” may support communication of risk
Cefazolin Sodium: 100% (active ingredient)
Impurities: Trace byproducts from manufacturing below reporting threshold
Additives: May include buffers or diluents in clinical formulations (consult manufacturer label for details)
Inhalation: Move person to fresh air, seek medical attention for persistent cough or breathing difficulties
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, see a doctor if symptoms develop
Eye Contact: Rinse eyes with water for several minutes, remove contact lenses, continue rinsing, seek medical advice if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, get immediate medical assistance; allergic responses may require emergency intervention
Notes to Physician: Treat symptoms, monitor for allergic reaction, provide supportive care as needed
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Hazardous Combustion Products: May release nitrogen oxides, sulfur oxides, sodium compounds
Protective Equipment for Firefighters: Wear full protective gear including self-contained breathing apparatus
Special Procedures: Avoid dispersing dust; move containers away from fire area if safe to do so
Flammability: Not highly flammable, but powder may burn if exposed to heat and flame
Personal Precautions: Avoid breathing dust, prevent skin and eye contact, use appropriate PPE
Environmental Precautions: Keep spills out of drains and watercourses
Cleanup Measures: Vacuum (with HEPA filter) or wet-sweep powders; avoid dry sweeping; place waste in sealed containers for proper disposal
Decontamination: Wash area with water and mild detergent after substance is removed
Notification: Report large or hazardous spills to local authorities as required
Handling: Wear gloves, masks, and protective eyewear; keep workspaces clean to prevent dust accumulation
Avoid Exposure: Particularly important for individuals with known allergies or with chronic respiratory conditions
Storage Requirements: Store in tightly closed containers; keep in dry, cool, and well-ventilated areas, away from incompatible substances
Specific Controls: Use dedicated equipment or disposable supplies when handling bulk powder to prevent cross-contamination with other drugs
Engineering Controls: Work in fume hood or local exhaust ventilation when handling active ingredient
Respiratory Protection: Use NIOSH-approved particulate respirator if dust is present
Skin Protection: Chemical-resistant gloves, long-sleeved lab coats
Eye/Face Protection: Safety goggles or face shield
Hygiene Measures: Wash hands after handling, avoid eating or drinking around material, remove contaminated clothing promptly and launder before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless or faint medicinal smell
Solubility: Freely soluble in water, practically insoluble in alcohol, chloroform, and ether
pH (solution): 4.5 to 6.0 (reconstituted)
Molecular Weight: 476.5 g/mol (sodium salt)
Melting Point: Decomposes before melting
Boiling Point: Not applicable (organic compound, decomposes)
Vapor Pressure: Negligible
Partition Coefficient (log Kow): Not available
Flash Point: Not determined
Chemical Stability: Stable under recommended storage conditions
Thermal Decomposition: Prolonged exposure to heat or moisture leads to degradation
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, sodium compounds, possibly toxic fumes
Reactivity: No dangerous reactions known under normal handling and storage
Acute Toxicity: LD50 (oral, rat): >2000 mg/kg, not highly toxic by ingestion
Routes of Exposure: Inhalation, skin, eyes, accidental ingestion
Symptoms: Allergic reaction (rash, itching, anaphylaxis in severe cases); gastrointestinal distress if ingested; respiratory irritation from dust
Chronic Effects: Repeated exposure in susceptible individuals may cause sensitization
Mutagenicity/Carcinogenicity: Not classified as carcinogenic or mutagenic
Reproductive Toxicity: No evidence of adverse reproductive effects in animal studies
Ecotoxicity: Low environmental toxicity reported; antimicrobial action may affect aquatic and microbial communities at high concentrations
Persistence and Degradability: Moderately biodegradable, but may persist in water if used in large volumes
Bioaccumulation: Not expected to bioaccumulate
Mobility in Soil: Water-soluble, may migrate through soil and reach groundwater
Other Effects: Antibiotic properties could impact sewage treatment and natural microbial ecosystems if released in significant amounts
Waste Disposal Methods: Dispose of unused material, contaminated PPE, and clean-up residue as pharmaceutical waste in accordance with local regulations
Incineration: Suitable for large quantities, using high-temperature, licensed facilities
Prohibitions: Do not flush to sewer or waterway, avoid landfill disposal when possible
Container Disposal: Rinse and render packaging unusable before discarding according to hazardous waste rules
Regulatory Guidance: Consult local, regional, and national guidelines for pharmaceutical and antibiotic disposal
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Cefazolin Sodium
Packing Group: Not assigned
Hazard Labels: None mandated for road, air, or sea
Special Precautions: Protect containers from moisture and extreme temperatures during transport
Transport Regulation: Not a regulated hazardous material under IATA, IMDG, or DOT for standard clinical volumes
US Regulations: Listed as prescription-only drug, not a hazardous substance per OSHA; reportable quantities for bulk material governed by EPA and FDA
EU Regulations: Classified under medicinal products directive; not listed as hazardous under REACH
Workplace Standards: Not assigned a specific occupational exposure limit; general dust and pharmaceutical safety guidelines apply
Other Global Standards: Follow local, regional, and international protocols for pharmaceutical handling and environmental safety
Labeling Guidelines: Containers and packaging to indicate prescription use, risk of allergic reaction, and proper handling instructions
