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Product Name: Cefathiamidine
Other Names: Cefathiamidine Hydrochloride, Semisynthetic Cephalosporin
CAS Number: 37051-76-6
Recommended Use: Antibiotic agent, pharmaceutical substance
Manufacturer: Refer to supplier label for updated manufacturing details
Contact Information: Emergency phone number and supplier contact found on the original container label
GHS Classification: Not classifiable as hazardous according to GHS standards for pharmaceuticals in final dosage forms
Main Hazards: Risk of sensitization in allergic individuals, mild skin and eye irritation, respiratory exposure possible during handling bulk powder
Signal Word: Warning
Pictograms: Exclamation mark symbol
Hazard Statements: May cause allergic skin reaction, possible respiratory tract irritation
Precautionary Statements: Avoid dust formation, keep out of reach of children, wash hands thoroughly after handling
Cefathiamidine: 90-100% (active pharmaceutical ingredient)
Other Ingredients: Trace process-related impurities or excipients for formulated products
Molecular Formula: C16H17N7O4S4
Molecular Weight: 487.6
Skin Contact: Remove contaminated clothing, flush exposed skin with soap and water for at least 15 minutes
Eye Contact: Rinse with plenty of clean water for at least 15 minutes, remove contact lenses if present
Inhalation: Move to fresh air, keep warm and at rest, seek medical attention if symptoms develop
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel
Medical Attention and Special Treatment: Allergic reactions need immediate treatment, present this data sheet to physicians
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol resistant foam
Unsuitable Extinguishing Media: High volume water jet
Special Hazards: Combustion forms carbon oxides, nitrogen oxides, sulfur oxides, hydrochloric acid fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Fire-Fighting Methods: Avoid raising dust, contain contaminated run-off, ventilate area post-extinguishment
Personal Precautions: Avoid contact with skin and eyes, wear dust-resistant respirators, ensure proper lab ventilation
Environmental Precautions: Prevent entry into sewers or waterways, contain spill with absorbent barriers
Spill Clean-Up Methods: Vacuum or sweep up to minimize dust, place in closed container for disposal, wash spill site with water after material pickup
Decontamination: Wash tools and floor surfaces with soap and water after collection
Safe Handling: Use in well-ventilated work areas, avoid creating dust or aerosols, wear required PPE
Conditions for Safe Storage: Store in tightly closed, moisture-resistant containers, protect from light, store at 2–8°C unless otherwise indicated
Incompatible Materials: Strong oxidizing agents, acidic and basic substances may affect stability
Regulatory Storage Category: Non-hazardous for general warehouse purposes, treat as prescription pharmaceutical
Special Precautions: Restrict access to authorized healthcare or laboratory personnel
Occupational Exposure Limits: Not established for cefathiamidine, keep airborne levels as low as possible
Engineering Controls: Use local exhaust ventilation or process enclosures wherever dust or aerosols could occur
Personal Protective Equipment: Nitrile gloves, long-sleeved lab clothing, chemical splash goggles
Respiratory Protection: Dust mask or NIOSH-approved respirator if airborne concentrations will be significant
Hygiene Measures: Wash hands after handling, remove PPE before eating or drinking
Appearance: White to pale yellow crystalline powder
Odor: Odorless or faint
pH (solution): 2.0-4.0 (in aqueous solution)
Solubility: Freely soluble in water, practically insoluble in solvents like chloroform or ether
Melting Point: Decomposes above 235°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Vapor Pressure: Not available
Stability in Solution: Hydrolyzes in alkaline media, heat, and strong light
Chemical Stability: Stable under recommended storage at 2-8°C and away from light
Conditions to Avoid: High temperatures, moisture, exposure to strong light
Incompatible Materials: Strong acids, bases, and oxidizing agents
Hazardous Decomposition Products: Sulfur oxides, carbon oxides, nitrogen compounds, hydrochloric acid fumes
Polymerization: Does not undergo polymerization under normal conditions
Acute Toxicity: Data in animals suggest low oral, dermal, and inhalation toxicity in normal exposure scenarios
Skin Corrosion/Irritation: May cause mild irritation on prolonged exposure
Serious Eye Damage/Irritation: Possibly irritating, not corrosive
Respiratory Sensitization: Sensitization possible if dust is formed and inhaled
Skin Sensitization: Risk of allergic response in sensitized individuals
Genotoxicity/Carcinogenicity: No evidence of mutagenicity or carcinogenicity in studies to date
Reproductive Toxicity: No specific data for teratogenicity; use during pregnancy only if benefit outweighs risk
Repeated Dose Toxicity: Based on animal studies, repeated exposure could affect liver and kidneys at high doses
Potential Health Effects: Allergic individuals may experience anaphylaxis upon contact or ingestion
Ecotoxicity: Not expected to pose significant environmental hazard at therapeutic concentrations released via patient use
Aquatic Toxicity: Limited data, cephalosporins can be toxic to aquatic microorganisms at elevated concentrations
Persistence and Degradability: Expected to degrade via hydrolysis and microbial activity
Bioaccumulative Potential: Likely insignificant, not expected to bioaccumulate
Mobility in Soil: Binds to organic matter, moderate mobility
Additional Environmental Hazards: Avoid uncontrolled release into the environment, wastewater treatment should remove residues
Waste Disposal Methods: Collect solid waste in tightly sealed, labeled containers, dispose as pharmaceutical waste in accordance with local regulations
Packaging Disposal: Triple-rinse containers, puncture to prevent reuse, dispose as hazardous or controlled waste
Contaminated Materials: Treat cleaning materials, PPE, and spill residues as pharmaceutical waste
Precautions: Do not discharge into surface water or municipal sewage without treatment
UN Number: Not assigned for pharmaceutical dry bulk
Transport Hazard Class: Not classified as dangerous for transport under ADR, IMDG, or IATA regulations
Packing Group: Not regulated
Special Transport Precautions: Protect container from damage, moisture, and direct sunlight
Label Requirements: No hazard label required in finished product form
Safety, Health, and Environmental Regulations: Subject to regulation for pharmaceuticals by national and regional health authorities
OSHA Status: Not specifically listed as a hazardous chemical by OSHA
TSCA Status: Not listed as a chemical under the U.S. Toxic Substances Control Act
WHMIS Classification (Canada): Exempt as a pharmaceutical
EU Directives: Controlled as medicinal product, not classified under EU dangerous substances guidelines
Additional Regulations: Use and disposal controlled under pharmaceutical and environmental legislation in each jurisdiction
