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Product Name: Cefamandole Nafate
Chemical Name: (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetamido]-3-[carbamoyloxy]methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
Synonyms: Cefaurethane sodium, Cefauretan sodium
CAS Number: 3485-14-9
Recommended Use: Antibiotic agent for clinical and laboratory use
Company Information: Manufacturer identification details should be included on actual documentation.
Emergency Overview: White to off-white powder, may cause allergic reactions, targets respiratory system on prolonged exposure.
Classification: Not listed as a controlled substance, but considered hazardous due to risk of sensitization and respiratory irritation.
Hazard Statements: May cause skin and eye irritation, possible respiratory sensitization, risk of allergic reactions.
Signal Word: Warning
Precautionary Statements: Avoid contact with eyes, skin, and clothing; do not breathe dust; individuals with penicillin or cephalosporin sensitivity may be at greater risk.
Component: Cefamandole Nafate (active ingredient)
Chemical Formula: C19H17N7NaO10S3
Concentration: 100% or as specified on label
Impurities: Trace manufacturing byproducts may be present, generally less than 1%
Inhalation: Remove to fresh air immediately, seek medical attention if symptoms persist or develop
Skin Contact: Wash with plenty of soap and water for at least 15 minutes, remove contaminated clothing, medical attention if irritation continues
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, seek medical advice
Ingestion: Rinse mouth with water, do not induce vomiting, seek prompt medical help
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or appropriate foam
Unsuitable Extinguishing Media: Do not use high volume water jet as it may spread powder
Special Fire Fighting Procedures: Wear self-contained breathing apparatus and full protective gear
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides, sodium oxides
Personal Precautions: Use personal protective equipment, avoid breathing dust, keep unprotected persons away
Environmental Precautions: Prevent material from entering water sources or sewers
Cleanup Methods: Sweep up and place in suitable, properly labeled containers for disposal, ventilate area, avoid generating dust
Handling: Avoid exposure to eyes, skin, and clothing; use local exhaust or general ventilation; never eat, drink, or smoke while handling
Storage: Keep container tightly closed in dry, cool, and well-ventilated environment, protect from light and incompatible substances, store away from food and beverages
Engineering Controls: Work in a chemical fume hood or with local ventilation
Eye Protection: Safety goggles or face shield
Hand Protection: Nitrile or latex gloves
Body Protection: Lab coat or similar protective clothing
Respiratory Protection: Dust mask or respirator if exposure risk occurs
Hygiene Measures: Wash hands thoroughly after handling, do not touch face or exposed skin until safety precautions completed
Appearance: White or almost white crystalline powder
Odor: Odorless
Molecular Weight: 585.56 g/mol
Melting Point: Decomposes
Solubility: Freely soluble in water, practically insoluble in organic solvents
pH: Slightly acidic to neutral in water
Other Information: Stable as dry powder, sensitive to light and moisture
Chemical Stability: Stable under recommended conditions, decomposes above melting
Conditions to Avoid: Excessive heat, exposure to light, moisture
Incompatible Materials: Strong oxidizers, acids, alkalis
Hazardous Decomposition Products: May emit toxic fumes of carbon oxides, nitrogen oxides, sulfur oxides, sodium oxides
Acute Toxicity: May cause stomach upset, nausea, skin irritation
Chronic Effects: Repeated or prolonged exposure may result in allergic reactions (such as rash, asthma), risk of anaphylaxis in sensitive individuals
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Signs and Symptoms: Rash, itching, difficulty breathing, gastrointestinal upset
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: No significant data available, standard precautions apply
Ecotoxicity: Limited data available, antibiotics may pose risk to aquatic environments by disrupting microbial processes
Persistence and Degradability: Expected to have moderate persistence; breakdown products may retain biological activity
Bioaccumulative Potential: Likelihood of accumulation in aquatic organisms considered low
Mobility in Soil: Expected to be mobile in aqueous environment
Other Effects: Potential hazard for water systems, avoid discharge into environment
Waste Treatment Methods: Dispose of material in compliance with local, regional, and national regulations
Disposal of Packaging: Triple rinse empty containers before disposal, follow approved waste disposal methods for pharmaceutical materials
Additional Precautions: Do not release diluted or undiluted product into public waterways
Pharmaceutical Waste: Use licensed hazardous waste disposal contractor, record-keeping essential
UN Number: Not regulated for transport
Transport Hazard Class: Not classified as dangerous goods
Packing Group: None assigned
Proper Shipping Name: Cefamandole Nafate
Safety Precautions: Keep containers closed, avoid water or physical damage during transport
Safety, Health and Environmental Regulations: Product complies with applicable chemical safety and occupational health laws
US Federal Regulations: Not listed in SARA Title III or CERCLA; standard workplace safety practices required
International Regulatory Status: Subject to regulation as a prescription pharmaceutical, not controlled
Labeling Requirements: Must carry pharmaceutical and safety information
Inventory Status: Not included on TSCA inventory due to status as a drug ingredient
