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Product Name: Carprofen
Synonyms: Rimadyl, Carprofenum
Chemical Name: 6-chloro-α-methyl-9H-carbazole-2-acetic acid
CAS Number: 55453-84-6
Recommended Use: Veterinary anti-inflammatory medication
Supplier: Contact details provided by distributor or manufacturer
Emergency Contact Number: Access local emergency services or poison control
Hazard Classification: Eye irritation (Category 2A), Specific target organ toxicity (single exposure, Category 3), Acute oral toxicity (Category 4)
Signal Word: Warning
Hazard Statements: Causes eye irritation; may cause respiratory irritation; harmful if swallowed
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust; use only outdoors or in a well-ventilated area; wash hands thoroughly after handling; do not eat, drink or smoke when using this product
Potential Health Effects: Eye and skin irritation, respiratory discomfort, gastrointestinal upset if ingested
Chemical Identity: Carprofen
CAS Number: 55453-84-6
Concentration: 100% pure substance or as specified in commercial formulations
Impurities: May contain minor manufacturing-related impurities, typical of pharmaceutical grade material
Additives: None for pure substance
Inhalation: Move individual to fresh air immediately; seek medical attention if symptoms develop or persist.
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing and wash before reuse.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids occasionally; remove contact lenses if present and easy to remove; seek medical help for persistent irritation.
Ingestion: Do not induce vomiting; rinse mouth with water; seek prompt medical attention.
Note for Physicians: Symptomatic treatment recommended; no specific antidote known
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam.
Unsuitable Extinguishing Media: Avoid high pressure water streams that may spread burning material.
Specific Hazards: Combustion may produce toxic and irritating fumes, such as hydrogen chloride, nitrogen oxides, and carbon monoxide.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear to prevent exposure to products of combustion.
Special Instructions: Cool exposed containers with water spray and evacuate area if fire becomes uncontrolled
Personal Precautions: Use appropriate personal protective equipment, including gloves, safety glasses, and masks to prevent dust inhalation.
Environmental Precautions: Prevent substance from entering drains, sewers, or waterways; contain spill to avoid environmental contamination.
Methods for Clean Up: Sweep up carefully without generating excessive dust and transfer to a suitable waste container; ventilate area; wash spill site after material pickup
Disposal: Dispose of collected residue in compliance with local regulations to avoid pollution
Secondary Exposure Prevention: Minimize handling and use only trained personnel in cleanup
Handling: Avoid contact with skin, eyes, and clothing; minimize dust generation; work in a well-ventilated area and use personal protective equipment as needed.
Storage Requirements: Store in tightly closed container in a cool, dry, and well-ventilated location away from incompatible materials, such as strong acids, bases, and oxidizing agents.
Temperature Sensitivity: Protect from exposure to excessive heat and direct sunlight to maintain stability
Labeling: Clearly mark containers with product identity and hazard warnings
Hygiene Recommendations: Do not eat, drink, or smoke in areas where this chemical is handled; wash thoroughly after handling
Engineering Controls: Use local exhaust ventilation or general room ventilation to minimize airborne concentrations.
Personal Protective Equipment: Wear chemical resistant gloves (nitrile or neoprene), safety goggles, and lab coats.
Respiratory Protection: Use dust mask or respirator in situations with poor ventilation or where dust generation is probable.
Environmental Controls: Implement spill containment and proper waste management practices to protect natural resources
Exposure Limits: No established occupational exposure limits for carprofen, handle with pharmaceutical compound precautions
Appearance: White to off-white powder
Odor: Odorless
Molecular Formula: C15H12ClNO2
Molecular Weight: 273.7 g/mol
Melting Point: 196-200°C
Solubility: Slightly soluble in water, soluble in organic solvents like DMSO and methanol
pH: Not applicable in solid form
Boiling Point: Not applicable (decomposes prior to boiling)
Vapor Pressure: Negligible
Flash Point: Data not available
Partition Coefficient (log Pow): 4.13
Density: Data not available for powder form
Chemical Stability: Stable under recommended storage conditions; light and heat sensitivity can affect shelf life.
Reactivity: Not highly reactive under normal conditions.
Possible Hazardous Reactions: Strong oxidizing agents may oxidize the compound, generating hazardous decomposition products
Conditions to Avoid: Excessive heat, exposure to sunlight, moisture
Hazardous Decomposition Products: Fumes of carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides in case of combustion or decomposition
Routes of Exposure: Inhalation, ingestion, and skin or eye contact
Acute Toxicity: Harmful if swallowed; estimated LD50 (oral, rat) about 282 mg/kg
Chronic Effects: Prolonged exposure may affect liver, gastrointestinal system, and may produce allergic reactions; repeated exposure increases risk
Symptoms: Nausea, vomiting, abdominal pain, eye redness, skin irritation, respiratory discomfort if inhaled
Sensitization: Rare cases of skin sensitization reported in pharmaceutical workers
Carcinogenicity/Mutagenicity: Not classified as a human carcinogen; no mutagenic effects noted in available testing
Reproductive Toxicity: No firm evidence in animal studies; recommended precautions for pregnant women
Ecotoxicity: Toxic to aquatic organisms, especially fish and invertebrates; potential for bioaccumulation requires downstream consideration
Persistence and Degradability: Moderately persistent; partial biodegradation in aquatic environments reported
Mobility in Soil: Moderate mobility in soil, with binding to organic matter
Bioaccumulative Potential: Moderate to high, log Pow indicates tendency to accumulate in biota
Other Harmful Effects: Unused or waste product may pose risk to domestic animals or wildlife if improperly disposed
Waste Disposal Methods: Incineration in authorized hazardous waste facility recommended for bulk quantities; small quantities can go in hazardous pharmaceutical waste streams
Contaminated Packaging: Triple rinse containers, render unusable, and dispose according to local hazardous waste regulations
Regulatory Requirements: Waste handlers must follow national and local environmental protection standards
Do Not Dispose: Never discharge into drains, watercourses, or soil
Community Guidance: Collect unused medicine from pet owners through take-back programs to limit environmental loading
UN Number: Not classified as a dangerous good for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: No direct aquatic hazard label required, though bulk spills must be avoided
Special Precautions: Shield from moisture and direct sunlight during transport; secure closed containers
TSCA Status (USA): Not listed for non-human pharmaceuticals
WHMIS Classification (Canada): Pharmaceutical product exemption
REACH (EU): Exempt as veterinary active ingredient
OSHA (USA): Not subject to specific hazard communication standards for finished pharmaceuticals; exercise general safety controls
Waste Classification: Handle as hazardous pharmaceutical waste for disposal
Other Local Regulations: Labeling and handling instructions depend on national and state requirements; users required to comply with pharmaceutical storage laws
