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Material Safety Data Sheet for Carbocisteine

1. Identification

Product Name: Carbocisteine
Chemical Name: (R)-2-amino-3-(carboxymethylsulfanyl)propanoic acid
Synonyms: S-Carboxymethyl-L-cysteine
CAS Number: 638-23-3
Recommended Use: Pharmaceutical applications, expectorant
Manufacturer: [Contact Information, Company Name, Address]
Emergency Contact: [Phone Number, Email Address]
Supplier: [Supplier Information as required]

2. Hazard Identification

GHS Classification: Not a hazardous substance or mixture according to the Globally Harmonized System
Label Elements: None required
Hazard Statements: May cause mild skin or eye irritation
Precautionary Statements: Avoid inhalation, ingestion, or contact with skin and eyes
Other Hazards: Not known to pose chronic health risks under normal use; dust may cause respiratory irritation

3. Composition / Information on Ingredients

Chemical Name: Carbocisteine
Chemical Formula: C5H9NO4S
Molecular Weight: 179.19 g/mol
Concentration: >99% (pure substance)
Impurities: Trace organic or inorganic contaminants less than 0.1%
Additives: None intentionally added

4. First Aid Measures

Inhalation: Move to fresh air, seek medical attention if breathing becomes difficult
Eye Contact: Rinse with plenty of water for at least 15 minutes, consult physician if irritation persists
Skin Contact: Wash affected area thoroughly with soap and water; remove contaminated clothing
Ingestion: Rinse mouth with water; do not induce vomiting without medical advice; obtain medical attention in case of distress
Symptoms: Irritation of respiratory tract, eyes, or skin can happen especially in people with sensitivity or pre-existing conditions

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Unsuitable Media: Avoid high-pressure water streams
Specific Hazards: Burns can release irritating or toxic sulfur oxides, nitrogen oxides, carbon monoxide
Protective Equipment: Wear self-contained breathing apparatus and protective gear
Advice for Firefighters: Evacuate area, avoid inhalation of combustion products, contain runoff water

6. Accidental Release Measures

Personal Precautions: Use gloves, goggles, lab coat, and mask if dust forms
Environmental Precautions: Prevent entry into drains, waterways, and soil
Methods for Cleanup: Sweep or shovel into suitable container for disposal, ventilate area, clean residue with damp cloth
Disposal: Dispose of material and contaminated containers according to local, regional, or national regulations

7. Handling and Storage

Handling: Avoid breathing dust, minimize dust generation, use in well-ventilated area, do not eat or drink in work area
Storage: Store in tightly closed container, keep in cool, dry place away from light, sources of ignition, oxidizing materials, or strong acids
Incompatibilities: Reacts with strong oxidizers or acids

8. Exposure Controls and Personal Protection

Exposure Limits: No specific occupational exposure limits available
Engineering Controls: Handle with local exhaust or general room ventilation
Respiratory Protection: Use approved dust mask or respirator in case of insufficient ventilation
Skin Protection: Wear chemical-resistant gloves
Eye Protection: Use safety glasses or goggles
Other Protection: Wear lab coat, avoid contact with skin and eyes, maintain good hygiene practices

9. Physical and Chemical Properties

Physical State: Solid
Appearance: White to off-white crystalline powder
Odor: Odorless or faint odor
pH (1% Solution): 2.5 - 3.5
Melting Point: 210 - 230°C (with decomposition)
Boiling Point: Not available (decomposes before boiling)
Solubility: Soluble in water, slightly soluble in alcohol
Partition Coefficient: Log Pow: -2.8
Vapor Pressure: Not applicable
Density: Approx. 1.3 g/cm³
Flash Point: Not flammable
Auto-ignition Temperature: Not self-igniting
Explosive Properties: Not known to be explosive

10. Stability and Reactivity

Chemical Stability: Stable under normal conditions, sensitive to high heat or strong acids
Reactivity: Reacts with strong oxidizing agents, strong acids
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Does not undergo hazardous polymerization
Conditions to Avoid: High temperature, open flames, incompatible chemicals

11. Toxicological Information

Acute Toxicity: Oral LD50 (rat): >5000 mg/kg
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity based on available data
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Mild irritation possible with dust exposure
Sensitization: Not expected to sensitize skin or respiratory tract
Other Data: Used as a medicine, but large amounts might cause gastrointestinal upset

12. Ecological Information

Ecotoxicity: Not expected to be acutely harmful to aquatic or terrestrial organisms based on available evidence
Mobility: High water solubility suggests significant mobility in soil
Persistence and Degradability: Readily biodegradable
Bioaccumulation: Low bioaccumulation potential (Log Pow <0)
Other Adverse Effects: Avoid discharge in large quantities into environment to minimize risks

13. Disposal Considerations

Waste Treatment Methods: Collect and transfer to approved chemical waste facility
Disposal of Unused Product: Dispose as non-hazardous chemical waste via incineration or landfill in accordance with local regulations
Contaminated Packaging: Rinse containers before disposal, follow standard procedures for plastic and glass disposal
Special Precautions: Prevent uncontrolled release to the environment, keep away from watercourses

14. Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not classified as dangerous for transport
Transport Hazard Class: None
Packing Group: None
Marine Pollutant: No
Special Precautions: Protect from direct sunlight and moisture during transit
Transport in Bulk: Not applicable

15. Regulatory Information

Regulatory Status: Not listed as hazardous under major regulations (OSHA, ECHA, REACH, TSCA, IARC)
Safety Assessment: Approved for medicinal use in many countries, but subject to prescription and pharmaceutical control
TSCA Inventory: Listed
EINECS Number: 211-334-0
Restrictions: For laboratory, research, or pharmaceutical use only; not intended for food or cosmetic applications
Notification Requirements: Ensure registration and notification according to local regulatory frameworks
Label Requirements: Exempt from hazard labeling except as required for workplace safety