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Product Name: Carbidopa
Chemical Name: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid
CAS Number: 28860-95-9
Manufacturer: Major pharmaceutical companies and suppliers
Recommended Use: Pharmaceutical intermediate, antiparkinsonian agent
Synonyms: L-(-)-α-Hydrazino-3,4-dihydroxy-α-methylpropionic acid
Classification: Not classified as hazardous according to OSHA Hazard Communication Standard
Label Elements: No hazard pictogram required; precautionary labeling may refer to dust inhalation and skin contact
Potential Health Effects: Eye irritation, mild respiratory discomfort, possible reactions in sensitive individuals
Emergency Overview: White to off-white powder, not volatile, dust may cause mechanical irritation of eyes or mucous membranes
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Chemical Name: Carbidopa
CAS Number: 28860-95-9
Concentration: 100% (pure substance)
Impurities / Stabilizers: None expected in pharmaceutical-grade lots
Molecular Formula: C10H14N2O4
Molecular Weight: 226.23 g/mol
Eye Contact: Flush eyes with water for at least 15 minutes, lifting eyelids, seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, get medical attention in case of persistent irritation
Inhalation: Move to fresh air, keep person comfortable, seek medical help if symptoms do not resolve
Ingestion: Rinse mouth, drink water if conscious, do not induce vomiting unless directed by medical personnel, obtain medical attention
Important Symptoms: Eye redness, sneezing or coughing, mild skin irritation
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam
Unsuitable Extinguishing Media: Strong water jet may cause splatter
Specific Hazards: Decomposition may give off nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Self-contained breathing apparatus, chemical resistant clothing
Firefighting Instructions: Avoid inhaling fumes or gases from decomposition, use typical methods to limit spread of fire, remain upwind
Personal Precautions: Put on protective gloves, safety goggles, NIOSH-approved dust mask
Environmental Precautions: Prevent entry to sewers or waterways, sweep up spills without raising dust, ventilate area
Methods for Containment and Cleanup: Pick up with minimum dust generation using dry methods, place in properly labeled containers for disposal, wash area with water
Other Information: Dispose of according to local regulations, minimize area contamination, remove personnel if significant dust forms
Handling: Wear personal protective equipment, handle in ventilated areas, avoid generating dust, wash hands after use
Storage Conditions: Keep in tightly closed, dry containers, store away from light and moisture, maintain storage temperature below 25°C
Incompatible Materials: Strong oxidizing agents, strong acids, reducing agents
Precautions: Post safety signage, keep away from food and drinks, ensure containers are clearly labeled
Exposure Limits: No OSHA or ACGIH exposure limits specifically for carbidopa, limit exposure to dust and airborne particles
Engineering Controls: Local exhaust ventilation, closed handling systems for large scale
Eye Protection: Safety glasses or chemical splash goggles
Skin Protection: Lab coats, gloves (nitrile recommended)
Respiratory Protection: NIOSH-approved dust mask or respirator in high-exposure situations
Hygiene Measures: Wash hands and face before eating or drinking, no smoking or eating in work zone
Appearance: White to off-white crystalline powder
Odor: None
Odor Threshold: Not applicable
pH: 3.5 – 4.5 (saturated solution)
Melting Point: 276–278°C (with decomposition)
Boiling Point: Not applicable (decomposes on heating)
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not considered flammable
Vapor Pressure: Not available
Vapor Density: Not available
Relative Density: 1.5–1.7
Solubility: Soluble in water
Partition Coefficient (n-octanol/water): <0.5
Auto-Ignition Temperature: Not available
Decomposition Temperature: Over 200°C
Viscosity: Not applicable
Chemical Stability: Stable under normal ambient conditions, sensitive to light and moisture
Reactivity: No dangerous reactions identified in normal use
Incompatible Materials: Strong oxidizers, acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide on thermal breakdown
Conditions to Avoid: Prolonged exposure to heat, direct sunlight, damp storage
Acute Toxicity: Low acute toxicity expected, LD50 (oral, rat) estimated > 5000 mg/kg
Skin Corrosion/Irritation: May cause slight irritation to sensitive skin
Serious Eye Damage/Irritation: Dust may cause mechanical irritation
Respiratory Sensitization: May cause mild irritation
Germ Cell Mutagenicity: Not established
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No known reports in humans, typical use occurs under medical supervision
Other Effects: Chronic exposure data not available, high dust levels should be avoided
Ecotoxicity: Not expected to be acutely harmful; pharmaceutical disposal may impact aquatic life with improper disposal
Persistence and Degradability: Expected to persist slightly in the environment due to chemical stability
Bioaccumulative Potential: Low due to high water solubility and low partition coefficient
Mobility in Soil: Expected to be mobile in water due to solubility
Other Adverse Effects: Data limited; safe disposal practices recommended to prevent contamination
Waste Disposal Methods: Place solid or contaminated cleanup materials in sealed, labeled containers, follow facility procedures and local regulations
Do Not: Allow product to reach sewage system or water bodies
Additional Information: Consider incineration for large amounts, consult waste disposal contractor for advice on sealed pharmaceutical substances
Special Precautions: Double-bag and box for transport to waste handler, document disposal in accordance with state pharmaceutical waste controls
UN Number: Not regulated for road, air, or sea transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not hazardous under international transport protocol
Packing Group: Not assigned
Special Precautions for User: Protect containers from wetting or physical damage, label as pharmaceutical product
Environmental Hazards: None significant, avoid spillage during transport
OSHA Status: Not regulated
EPA Status: Not listed as hazardous substance
TSCA: Listed
IARC/NTP/OSHA Carcinogen List: Not listed
State Regulatory Status: Not specifically regulated under California Proposition 65
International Inventories: Included in several chemical inventories; status checked depending on use country
Other Information: Medical use regulated by prescription laws, workplace exposure kept as low as reasonably achievable
