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Material Safety Data Sheet: Carbetapentane Citrate

Identification

Product Name: Carbetapentane Citrate Chemical Name: 1,2,3,6-Tetrahydro-1,1-dimethyl-3-phenylpyridine citrate SYNONYMS: Pentoxyverine Citrate Trade Names: Carbetapentane, Pentoxyverine Recommended Use: Antitussive (cough suppressant) in pharmaceutical preparations Manufacturer: Provided by pharmaceutical manufacturing company; emergency contact details should always be checked on the product label Contact Telephone: Manufacturer’s main telephone line CAS Number: 77-09-8 UN Number: Not classified under current transport regulations Product Code: Refer to specific supplier documentation Address: See product packaging or supplier

Hazard Identification

Classification: Not classified as hazardous according to current GHS criteria, but overdosing or inhalation of dust can create a health risk Physical Hazards: May produce fine dust during manufacture or handling Health Hazards: Potential for central nervous system effects in overdose; may irritate respiratory tract; large exposures may cause drowsiness, dizziness, or nausea Environmental Hazards: No significant acute risk, but avoid contamination of drains or waterways Signal Word: No signal word for standard use; overdose and improper handling may change risk profile Pictograms: No GHS pictogram required Precautionary Statements: Do not breathe dust; wash hands thoroughly after handling; avoid release to environment Other Hazards: Careful with dust formation and ingestion beyond recommended dose; improper disposal could impact aquatic environments

Composition / Information on Ingredients

Chemical Structure: 1,2,3,6-Tetrahydro-1,1-dimethyl-3-phenylpyridine citrate Active Ingredient: Carbetapentane Citrate CAS Number: 77-09-8 (Carbetapentane base) Concentration: Typically supplied as a 100% active pharmaceutical ingredient or diluted in formulation Impurities: Pharmaceutical grade, low impurity within regulatory specifications Additives: Formulations may contain excipients like lactose, corn starch, or microcrystalline cellulose (see drug specification)

First Aid Measures

Inhalation: Move to fresh air. Seek medical attention for any symptoms like dizziness, confusion, or respiratory discomfort Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical advice and show this safety sheet Skin Contact: Wash thoroughly with soap and water. Remove contaminated clothing and launder before reuse. Seek attention if irritation persists Eye Contact: Rinse immediately with water for fifteen minutes; keep eyes wide open; seek medical attention if irritation or pain continues Most important symptoms/effects: Headache, drowsiness, nausea, dizziness, possible respiratory depression in case of major exposure Special Treatment: Symptomatic and supportive care; medical professionals may use activated charcoal if significant ingestion is suspected

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, CO2, or foam Unsuitable Extinguishing Media: Avoid high-pressure streams Special Hazards: Fire may produce hazardous decomposition products like nitrogen oxides, carbon monoxide, and carbon dioxide Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear; approach fire from upwind side Other Advice: Use water spray to cool containers near fire; prevent runoff from entering waterways

Accidental Release Measures

Personal Precautions: Avoid generating dust; ventilate area; prevent contact with skin, eyes, and clothing; use suitable personal protective equipment Environmental Precautions: Prevent entry into drains, sewers, or waterways; minimize environmental contamination Cleanup Methods: Sweep or vacuum up material using methods that minimize dust generation; collect in closed, labeled containers for disposal Other Precautions: Avoid dry sweeping if possible—use a dust suppressant or wet method

Handling and Storage

Handling Protections: Prevent dust formation; wash hands after handling; keep containers tightly closed when not in use Fire/Explosion Hazards: Not flammable in typical storage, but fine powder may present dust explosion risk in rare circumstances Storage Conditions: Keep in cool, dry, well-ventilated area away from incompatible substances; store in original container Incompatible Materials: Strong oxidizing agents; acids and bases may affect stability Other Storage Advice: Keep out of reach of children; ensure packaging is secure and labeled

Exposure Controls and Personal Protection

Control Parameters: No occupational exposure limit established; general pharmacy or lab dust limits may apply Engineering Controls: Use appropriate local exhaust ventilation to keep airborne concentrations below recommended limits Respiratory Protection: Use NIOSH-approved dust mask or respirator if dust is generated and ventilation is inadequate Hand Protection: Wear protective gloves made of nitrile or other resistant material Eye Protection: Chemical safety goggles recommended Skin/Body Protection: Laboratory coat or coveralls Hygiene Measures: Do not eat, drink, or smoke when handling this product; wash hands before breaks and at end of work

Physical and Chemical Properties

Appearance: White to off-white crystalline powder Odor: Odorless or faint pharmaceutical smell pH: Not applicable in solid state; weakly acidic in aqueous solution Melting Point: Around 168–172 °C for carbetapentane citrate Boiling Point: Decomposes before boiling Solubility: Freely soluble in water, alcohol Vapor Pressure: Not applicable Density: Information not typically required; consult supplier Flash Point: Not applicable (combustible only as dust) Partition Coefficient (log Pow): Data limited; generally low as citrate salt Stability in Light/Heat: Stable under reasonable conditions

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions Hazardous Reactions: None under normal handling Incompatible Materials: Strong acids, strong bases, oxidizing agents Thermal Decomposition: May produce irritating fumes, nitrogen oxides, carbon monoxide, carbon dioxide when heated to decomposition Polymerization: Will not occur Other Advice: Keep away from sources of extreme heat or sunlight

Toxicological Information

Acute Toxicity: Low acute toxicity at therapeutic doses; may cause CNS effects, respiratory depression, or GI symptoms at high doses Skin Corrosion/Irritation: Not a primary irritant under routine exposure Eye Damage/Irritation: May cause discomfort, avoid direct eye contact Respiratory Sensitization: Fine dust can cause respiratory discomfort Carcinogenicity: No classification by IARC, NTP, or OSHA Reproductive Toxicity: No evidence available in humans; not recommended in pregnancy unless benefit outweighs risk Chronic Effects: See package insert; misuse can be hazardous Other Effects: May cause drowsiness or dizziness

Ecological Information

Toxicity to Aquatic Life: Not acutely toxic in small quantities but pharmaceuticals can be harmful to aquatic organisms in bulk Persistence/Degradability: Expected to be moderately biodegradable Bioaccumulation: Low potential Mobility in Soil: Data not extensively studied; citrate salt increases water solubility Other Adverse Effects: Avoid uncontrolled release to environment

Disposal Considerations

Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations Waste Code: Dispose using special pharmaceutical waste channels Packaging Disposal: Empty containers should be decontaminated and disposed of safely Environmental Precautions: Do not discharge into drains or watercourses

Transport Information

UN Number: Not regulated as a hazardous material for transport UN Proper Shipping Name: Not regulated Hazard Class: None Packing Group: None Transport Precautions: Protect packages from physical damage and moisture during transit Marine Pollutant: Not designated Additional Transport Information: Follow national/international parcel rules for pharmaceuticals

Regulatory Information

Product Safety: Approved for pharmaceutical use according to national drug regulatory agencies Labeling Requirements: Product labeling must comply with drug regulations, include risk and safety phrases OSHA Hazard Communication: Not classified as hazardous GHS: Not classified as hazardous on its own Controlled Substance Status: Varies by country—consult national drug schedules Inventory Status: Listed in national inventories as pharmaceutical Other Regulatory Notes: Comply with workplace health and safety regulations for pharmaceuticals