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Product Name: Carbamazepine
Chemical Name: 5H-dibenz[b,f]azepine-5-carboxamide
Synonyms: Tegretol, Atretol, Carbamazephine
CAS Number: 298-46-4
Recommended Use: Pharmaceutical ingredient, anticonvulsant, mood stabilizer
Supplier Information: Complete name, address, emergency phone number of the supplying company
Emergency Contact: National Poison Center or equivalent local resource
Formula: C15H12N2O
Classification: According to GHS—Acute toxicity (oral, dermal, inhalation); skin and eye irritant; may cause respiratory irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled; Causes serious eye irritation; May cause allergy or asthma symptoms
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust; wash skin after handling; use only outdoors or in a well-ventilated area; wear protective gloves, clothing, and eye protection
Potential Health Effects: Irritation to skin, eyes, and respiratory tract; adverse effects on liver, kidneys, or nervous system with repeated or prolonged exposure; allergic reactions in susceptible individuals
Environmental Hazards: Toxic to aquatic life with long lasting effects
Substance: Carbamazepine
Concentration: ≥98% pure active ingredient
Other Ingredients: Trace impurity levels only, specified by manufacturer
CAS Number: 298-46-4
EINECS: 206-062-7
Inhalation: Move person to fresh air, keep at rest, seek immediate medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, flush skin with soap and water, seek medical advice for irritation or allergic reaction
Eye Contact: Rinse thoroughly with water for at least fifteen minutes, lift eyelids occasionally, get prompt medical attention
Ingestion: Rinse mouth, do not induce vomiting, seek medical help and show the SDS
Most Important Symptoms: Nausea, drowsiness, confusion, rashes, labored breathing
Note to Doctor: Symptomatic treatment only; monitor for delayed neurological or hepatotoxic effects
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Unsuitable Extinguishing Media: Strong water jet
Hazards from Combustion: May produce toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide
Special Protective Equipment: Full protective clothing and self-contained breathing apparatus
Advice for Firefighters: Keep containers cool with water spray; prevent runoff water from entering drains or watercourses
Personal Precautions: Use appropriate personal protective equipment including gloves, safety goggles, NIOSH-approved respirator
Environmental Precautions: Prevent contamination of soil, surface, and groundwater; do not allow entry into drains or waterways
Clean-Up Methods: Sweep or vacuum spilled material carefully to avoid dust formation; transfer to properly labeled container for disposal; ventilate area well; wash the site with water after complete removal of material
Decontamination: Collect residues and wash affected area with detergent and water
Safe Handling: Avoid contact with eyes, skin, and clothing; avoid breathing dust; handle in a well-ventilated area or with exhaust ventilation; wash thoroughly after handling; never eat, drink, or smoke in work areas
Storage Conditions: Store in tightly closed original containers in a cool, dry, well-ventilated place out of direct sunlight; segregate from oxidizing agents, foodstuffs, solvents, and incompatible chemicals
Incompatible Materials: Strong acids, oxidizers, strong bases
Specific End Use: For pharmaceutical processing and research only; not for direct consumer use
Exposure Limits: No occupational exposure limits specifically established for carbamazepine in most jurisdictions; handle as an active pharmaceutical ingredient with appropriate containment
Engineering Controls: Local exhaust ventilation, process enclosures, and dust extraction system
Personal Protective Equipment (PPE): Chemical resistant gloves (nitrile, neoprene), laboratory coat or coveralls, safety goggles, face shield for large-volume operations, NIOSH-approved respirator or PAPR when handling bulk powder
Hygiene Measures: Do not eat, drink or smoke during use; wash hands and face before breaks and after handling
Environmental Controls: Prevent product from entering environment uncontrolled
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Slightly basic (in water)
Melting Point/Range: 189°C to 193°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable under standard conditions
Evaporation Rate: Not applicable
Flammability: Not easily ignitable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not determined
Specific Gravity: 1.34 (water = 1)
Solubility: Sparingly soluble in water; soluble in alcohol, acetone
Partition Coefficient (log Kow): 2.3
Autoignition Temperature: Not established
Decomposition Temperature: Above 193°C
Viscosity: Not relevant in solid state
Stability: Stable under normal temperatures and recommended storage conditions
Hazardous Reactions: Reacts with strong oxidizing agents, acids, or bases, which can cause decomposition
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, and possibly other harmful fumes
Polymerization: Will not polymerize
Conditions to Avoid: Excessive heat, direct sunlight, sources of ignition, incompatible materials
Acute Toxicity—Oral LD50 (rat): 1180-2500 mg/kg
Skin Corrosion/Irritation: May cause mild to moderate irritation on prolonged contact
Eye Damage/Irritation: Causes irritation with redness and pain
Sensitization: Allergic skin reactions and rare respiratory sensitization in sensitive individuals
Repeated Dose Toxicity: Liver and kidney damage documented in animal studies at high exposure
Carcinogenicity: Not classified as carcinogenic to humans by IARC; long-term effects uncertain
Mutagenicity: No strong evidence of mutagenicity in standard tests
Reproductive Toxicity: Developmental toxicity and birth defects reported in animal testing and rare human cases
Other Information: Possibility of Stevens-Johnson Syndrome or blood disorders (aplastic anemia, leukopenia) in susceptible individuals
Ecotoxicity: Harmful to aquatic organisms; toxic to fish, daphnia, and algae at moderately low concentrations
Persistence and Degradability: Not readily biodegradable; persists in the environment
Bioaccumulative Potential: Moderate potential, log Kow of 2.3 indicates risk in aquatic food chains
Mobility in Soil: Low to moderate; leaching to groundwater possible mainly in sandy or loose soils
Other Adverse Effects: Pharmaceutical residues detected in surface water and sewage effluent; risk of chronic aquatic exposure
Waste Treatment Methods: Must not be disposed of with household waste; incineration in a chemical incinerator with afterburner and scrubber recommended
Contaminated Packaging: Dispose of as unused product; decontaminate containers before recycling or discarding
Sewage Disposal: Avoid discharge to wastewater systems and natural waters
Precautions for Disposal: National and local regulations for pharmaceutical and hazardous waste apply; responsible lab/environmental officer should supervise all disposals
UN Number: Not classified as a hazardous substance under UN transport guidelines
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Not restricted
Packing Group: Not applicable
Marine Pollutant: No
Special Transport Precautions: Avoid release to environment; keep container tightly closed and upright during transport
ADR/RID, IATA, IMDG: Not listed as dangerous for these regulations; carriage requires general precautions for pharmaceuticals and powders
Safety, Health, and Environmental Regulations: Subject to workplace safety and environmental protection law in most jurisdictions; not listed as controlled under the US TSCA or listed substances regulations
OSHA Status: Not considered hazardous under 29 CFR 1910.1200
WHMIS (Canada): Class D2B - Toxic material causing other toxic effects
California Prop 65: Not listed
REACH/CLP (EU): Registration required for supply in quantities over 1 tonne/year; classification as harmful and irritant to health
Other Chemical Inventory Lists: Included on EINECS, AICS, DSL
Label Elements: Must provide warning regarding risk to health and aquatic environment; proper labeling for bulk transport and handling
