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Chemical Name: Captopril
Class: ACE inhibitor, antihypertensive agent
CAS Number: 62571-86-2
Common Appearance: White crystalline powder
Odor: Slight sulfur-like smell
Uses: Treatment of hypertension, heart failure, diabetic nephropathy
Molecular Formula: C9H15NO3S
Molecular Weight: 217.29 g/mol
Acute Risks: Can irritate eyes, skin, and respiratory tract on contact; risk of headache, cough, rash, taste disturbances in therapeutic use
Chronic Exposure: May impact kidney function, risk of angioedema
GHS Label Elements: Skin sensitization, specific toxicity to organs, irritation
Signal Word: Warning
Routes of Entry: Inhalation, ingestion, skin and eye contact
Carcinogenicity: Not classified as carcinogenic under IARC, NTP, or OSHA
Target Organs: Kidneys, cardiovascular system
Active Substance: Captopril (approximately 98% purity in pharmaceutical grade material)
Impurities: Trace related compounds, residual solvents
Excipients: None in raw bulk powder; pharmaceutical tablets may include starch, cellulose, magnesium stearate
Inhalation: Remove to fresh air immediately; seek medical attention if irritation persists
Skin Contact: Wash thoroughly with plenty of water and mild soap
Eye Contact: Rinse eyes with water for several minutes; obtain medical advice for persistent irritation
Ingestion: Seek medical advice promptly; do not induce vomiting unless instructed by healthcare professional
Health Surveillance: Individuals with chronic exposure should have periodic kidney function checks
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Combustion Products: Emits toxic fumes including sulfur oxides, nitrogen oxides, carbon oxides
Protective Equipment: Full protective gear, self-contained breathing apparatus
Special Hazards: Fine powders can form explosive mixtures in air
Precautions: Avoid inhalation of combustion gases, evacuate unnecessary personnel from area
Personal Protection: Use gloves, lab coat, goggles, dust mask
Spill Response: Sweep up without creating dust, place in sealed container for proper disposal
Environmental Precautions: Avoid release into sewers or surface water
Clean-Up Methods: Wash contaminated surfaces with water and detergent after material removal
Handling: Use only in well-ventilated areas; avoid generation of dust; prevent contact with skin, eyes, clothing
Storage: Store in tightly sealed container at controlled room temperature, away from moisture and heat sources
Incompatible Materials: Strong oxidizing agents, acids
Hygiene Measures: Do not eat, drink, or smoke during handling; wash hands thoroughly after use
Occupational Exposure Limits: No specific exposure limit established; minimize contact and dust exposure
Engineering Controls: Use local exhaust ventilation for bulk handling or weighing
Personal Protective Equipment: Safety goggles, protective gloves resistant to chemicals, laboratory coats
Respiratory Protection: Dust mask or respirator for high dust situations
Environmental Exposure Controls: Prevent run-off into waterways, implement procedures to contain accidental discharge
Appearance: Solid, white crystalline powder
Odor: Mild sulfur scent
Melting Point: 105-108°C
Solubility: Freely soluble in water and methanol
pH (aqueous solution): Acidic, typically around 2-3 in water
Boiling Point: Not applicable for solid compound
Vapor Pressure: Negligible at room temperature
Flash Point: Not flammable under normal conditions
Partition Coefficient (log Kow): Approximately 0.1
Chemical Stability: Stable when dry, degrades in presence of moisture and light
Conditions to Avoid: High humidity, exposure to light
Incompatible Materials: Strong acids, strong oxidizers
Decomposition Products: Sulfur dioxide, nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Not known to occur
Acute Toxicity: LD50 (oral, rat) reported between 1300-2100 mg/kg in animal studies
Potential Effects: Can cause skin rash, low blood pressure, taste disturbances, occasional cough
Sensitization: Risk of skin sensitization in sensitive individuals
Chronic Effects: Prolonged high doses may impact renal function or produce blood abnormalities
Special Risk Groups: Pregnant women, individuals with history of angioedema or kidney disease should use with great caution
Environmental Impact: Not expected to bioaccumulate, but persistence in aquatic systems causes concern
Aquatic Toxicity: Harmful to fish and aquatic organisms at high concentrations
Degradability: Partial biodegradability in soil and water; presence in wastewater effluent observed
Mobility in Soil: Moderate mobility due to water solubility
Precautionary Approach: Avoid uncontrolled release, support pharmaceutical waste management in hospitals and labs
Waste Handling: Dispose of in accordance with local regulations for pharmaceuticals
Methods: Incineration or secure landfill preferred for bulk waste
Precautions: Prevent contamination of soil and water; containers should be recycled or disposed of through licensed contractors
Unused or Expired Medication: Return to pharmacy take-back programs instead of sewer or trash
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Captopril, pharmaceutical preparation
Hazard Class: Not classified as hazardous by land, sea, or air
Packaging Recommendations: Use leak-proof containers, avoid moisture ingress
Regulatory Status: Listed under national and international pharmaceutical regulations; not subject to major chemical inventory restrictions
OSHA Classification: Not specifically regulated as hazardous chemical in workplace quantities
TSCA/REACH Listings: Registered as a pharmaceutical substance
Labeling: Prescription use only, controlled where relevant under medicine act
Other Compliance: Subject to disposal rules for pharmaceuticals and handling standards in health facilities
