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Product Name: Camptothecin
Synonyms: CPT, S-(+)-Camptothecin, Queen’s tree alkaloid
Chemical Formula: C20H16N2O4
CAS Number: 7689-03-4
Intended Use: Laboratory research, chemotherapy research
Manufacturer Information: Supplier address and emergency contact should be found on the original label; always verify before handling.
Recommended Restrictions: For research use only, not for human or veterinary use.
GHS Classification: Acute toxicity (oral, dermal, inhalation), Specific Target Organ Toxicity (repeated exposure), Eye irritation
Hazard Statements: Toxic if swallowed, contact causes severe irritation to eyes and skin, prolonged or repeated exposure may damage organs
Signal Word: Danger
Symbol: Skull and crossbones, Exclamation mark
Precautionary Statements: Avoid ingestion, inhalation, and skin contact. Wear protective gloves, clothing, and eye protection. Have proper ventilation and wash hands thoroughly after handling.
Chemical Name: Camptothecin
Concentration: 98-100% pure
Impurities: Minor levels of structural analogs, not typically relevant to acute hazard profile
Other Ingredients: None commonly present in laboratory samples
Eye Contact: Immediately rinse eyes with water for 15 minutes while holding eyelids open; seek medical attention without delay
Skin Contact: Remove any contaminated clothing, rinse skin thoroughly with water and soap; medical evaluation recommended
Inhalation: Move individual to fresh air, monitor for symptoms such as cough or respiratory distress, seek medical attention
Ingestion: Do not induce vomiting; rinse mouth with clean water and call poison control or healthcare provider
Most Important Symptoms/Effects: Nausea, vomiting, skin and eye irritation, possible damage to organs with repeated exposure
Advice for Physicians: Treat symptomatically, monitor for delayed reactions associated with cytotoxic compounds
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Extinguishing Media: Do not use high-pressure water stream
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides under fire conditions
Protective Equipment and Precautions for Firefighters: Full protective gear including self-contained breathing apparatus, avoid inhalation of combustion products, ensure proper ventilation
Fire/Explosion Hazards: Not particularly flammable, but toxic emissions possible
Personal Precautions: Wear suitable gloves, lab coat, and goggles, avoid breathing dust, ensure area is well-ventilated
Environmental Precautions: Prevent spill from entering drains, surface water, or soil
Containment and Cleanup Methods: Sweep carefully with minimal dust generation and place in appropriate, labeled waste container; decontaminate spill area with soap and water
Recommended Equipment: Use HEPA-filtered vacuum, disposable absorbent materials for small spills, consult safety office for large spills
Precautions for Safe Handling: Handle inside certified chemical fume hood, avoid exposure through inhalation, ingestion, and skin contact, use only with trained staff
Conditions for Safe Storage: Store in tightly closed containers in cool, dry, well-ventilated space, protect from light, clearly label storage areas
Incompatible Materials: Strong oxidizers, acids, and bases
Other Measures: Keep away from food, beverages, and personal items; restrict unauthorized access
Occupational Exposure Limits: No established OSHA or NIOSH values available; treat as hazardous by default standards
Engineering Controls: Chemical fume hood, local exhaust ventilation
Personal Protective Equipment (PPE): Nitrile or neoprene gloves, safety goggles, lab coat, approved respirator for dust/powder
Hygiene Measures: Remove protective gear and wash hands before leaving lab, avoid cross-contamination, do not eat or drink in work area
Environmental Controls: Implement spill containment and waste disposal controls in line with local regulations
Appearance: Pale yellow to off-white crystalline powder
Odor: Odorless
Molecular Weight: 348.36 g/mol
Melting Point: 265-270°C (decomposes)
Solubility: Slightly soluble in water, soluble in DMSO, methanol, ethanol
pH: Not applicable in solid form, slightly acidic in solution
Boiling Point: Not available
Vapor Pressure: Negligible under normal conditions
Density: Around 1.5 g/cm³
Partition Coefficient (log Kow): Not readily available
Evaporation Rate: Not expected to evaporate at room temperature
Chemical Stability: Stable under recommended storage conditions; susceptible to photodegradation and hydrolysis in aqueous media, especially at high pH
Possibility of Hazardous Reactions: No data on polymerization; reacts with strong oxidizing agents
Conditions to Avoid: Moisture, light, prolonged exposure to air
Materials to Avoid: Strong bases, acids, and oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide on decomposition under heat or fire
Routes of Exposure: Ingestion, inhalation, dermal, ocular
Acute Toxicity: LD50 (rat, oral) ≈ 100 mg/kg; toxic in small quantities, high risk to laboratory workers handling bulk material
Chronic Toxicity: Animal studies show hepatotoxicity, nephrotoxicity, and potential reproductive toxicity; evidence of DNA synthesis inhibition
Symptoms: Gastrointestinal distress, kidney and liver effects, skin and eye irritation, bone marrow suppression at higher doses
Sensitization: Not reported, but personnel should take standard precautions
Carcinogenicity: Not classifiable by IARC due to limited data; related compounds under investigation for antitumor activity
Mutagenicity and Reproductive Toxicity: Positive results in some in vitro tests; avoid exposure if planning pregnancy
Aquatic Toxicity: Harmful to aquatic life due to cytotoxic properties
Persistence and Degradability: Not readily biodegradable, subject to slow hydrolysis
Bioaccumulative Potential: Data insufficient, likely to be low due to poor solubility
Mobility in Soil: Limited due to low water solubility and strong adsorption to substrate
Other Effects: Cytotoxicity poses risk to sewage treatment systems if large quantities are disposed of improperly
Waste Disposal Methods: Collect waste in clearly labeled hazardous waste containers; hand over to licensed chemical disposal service
Unused Material: Do not pour in sink or municipal trash; treat as cytotoxic and follow institutional guidelines
Contaminated Packaging: Dispose of as hazardous waste; decontaminate before discarding if possible
Local Regulations: Follow all federal, state, and local procedures for hazardous chemical waste, consult environmental office if unsure
UN Number: Not assigned for small laboratory quantities, may require special classification for large shipments
Proper Shipping Name: Toxic solid, organic, n.o.s. (Camptothecin)
Transport Hazard Class: Class 6.1 (toxic substance)
Packing Group: III (moderate hazard)
Marine Pollutant: No specific information, but avoid release in transit
Special Transport Precautions: Securely pack and label, avoid physical damage, ensure emergency procedures are available during transport
OSHA Hazard Communication: Classified as hazardous; subject to laboratory safety standards
TSCA: Listed; use subject to research and development exemptions
SARA Title III: Not specifically listed; toxicity may trigger required reporting for certain quantities
California Proposition 65: Not listed as carcinogen or reproductive toxin
WHMIS Classification (Canada): D1B (toxic material causing immediate and serious toxic effects)
Other International Regulations: Subject to import/export regulations as a cytotoxic/cytostatic chemical
Workplace Labeling: Clearly label all storage and transport containers with identity, hazards, and emergency contacts as per GHS and local rules
