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Product Name: Calcium Levofolinate / Calcium Folinate
Chemical Name: (6S)-N-[p-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, calcium salt
Synonyms: Calcium folinate, Calcium leucovorin
CAS Number: 1492-18-8
Recommended Use: Pharmaceutical intermediate, medicinal active agent in chemotherapy rescue
Manufacturer: Details supplied by distributor or manufacturer
Contact Information: Emergency phone numbers typically supplied by manufacturer, local poison control or health authority
Emergency Overview: White to off-white powder, odorless
GHS Classification: Not classified as a hazardous substance under GHS criteria for this concentration
Potential Health Effects: Inhalation, ingestion, and skin contact may cause mild irritation; large-scale exposure effects not well documented
Eye Contact: Dust may cause eye irritation
Chronic Effects: Data lacking for long-term health impact
Environmental Effects: Not expected to be hazardous to environment under normal use
Signal Word: None required
Hazard Pictograms: None required
Precautionary Statements: Avoid creating dust, wash thoroughly after handling, use with good laboratory hygiene practice
Chemical Name: Calcium Levofolinate
Concentration: 97-100%
Cas Number: 1492-18-8
Impurities: Pharmaceutical grade may contain trace related substances under regulatory thresholds
Molecular Formula: C20H21CaN7O7
Molecular Weight: 511.51 g/mol
Inhalation: Move individual to fresh air, seek medical attention if symptoms persist
Skin Contact: Wash area with water and soap, remove contaminated clothing
Eye Contact: Rinse with copious amounts of water for several minutes, keep eyelids open, seek medical attention for continued irritation
Ingestion: Rinse mouth, drink water, do not induce vomiting, seek medical care if large amounts have been swallowed or adverse effects appear
Notes to Physician: Symptomatic treatment advised, no specific antidote on record
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable Media: Direct stream of water may spread powder
Hazardous Combustion Products: Oxides of carbon, nitrogen, calcium compounds, irritating fumes
Special Equipment: Firefighters should wear self-contained breathing apparatus, full protective gear
Special Hazards: Dust formation possible; product itself is not highly flammable but packaging may burn
Advice for Firefighters: Approach from upwind to avoid hazardous smoke gases, avoid breathing airborne particles
Personal Precautions: Avoid dust generation, ventilate area, use appropriate personal protective equipment including gloves and goggles
Environmental Precautions: Prevent product from entering drains or water sources
Cleanup Methods: Contain spill, sweep or shovel up material into suitable container for disposal, wash spill area with water if appropriate
Handling of Waste: Collected material should be managed based on local regulatory requirements; minimize dust exposure during cleanup
Handling: Use only in well-ventilated settings, avoid dust and contact with skin and eyes, wash hands after use
Storage: Store in tightly closed containers, in cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers
Container Materials: Use original packaging or chemical-resistant containers suitable for pharmaceuticals
Incompatibilities: Oxidizing agents, acids
Special Handling Advice: Implement good warehouse practices, keep away from children and unauthorized personnel
Exposure Limits: No occupational exposure limits established for this compound
Engineering Controls: Use local exhaust ventilation where dust may be generated
Personal Protective Equipment: Wear safety glasses or goggles, lab coat or apron, chemical-resistant gloves
Respiratory Protection: Dust mask or respirator if dust levels exceed recommended limits
Hygiene Measures: Wash hands and face after handling, no eating or drinking in work area, remove contaminated clothing before entering eating areas
Appearance: White to pale yellow powder
Odor: Odorless
pH: 6.5–8 (1% aqueous solution)
Melting Point: Decomposes before melting
Solubility: Freely soluble in water at room temperature, practically insoluble in ethanol and acetone
Boiling Point: Not applicable, decomposes at elevated temperatures
Vapor Pressure: Not expected to be volatile
Density: No data
Partition Coefficient (log Kow): Not available
Flash Point: Not applicable
Explosive Properties: Not explosive
Oxidizing Properties: Not oxidizing
Chemical Stability: Stable under standard conditions of temperature and pressure
Reactivity: No dangerous reactions known under normal conditions
Conditions to Avoid: Exposure to moisture, extreme heat, strong light
Materials to Avoid: Strong oxidizing agents, acids
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, calcium oxide, possibly toxic fumes
Acute Toxicity: No acute toxicity data available for humans, not expected to be acutely toxic based on structure and related compounds
Skin Corrosion/Irritation: Not classified as skin irritant
Serious Eye Damage/Irritation: Dust may cause mild irritation
Respiratory or Skin Sensitization: No evidence of sensitization
Mutagenicity: Not mutagenic in standard testing
Carcinogenicity: Not classified as carcinogen
Reproductive Toxicity: No reproductive toxicity at therapeutic doses
Specific Target Organ Toxicity – Single Exposure: No data
Specific Target Organ Toxicity – Repeated Exposure: No data
Potential Adverse Effects: Overdose may lead to gastrointestinal discomfort, rarely allergic reactions in sensitive individuals
Ecotoxicity: Not expected to be hazardous to aquatic or terrestrial environments under normal use
Persistence and Degradability: Data not available, likely biodegradable under environmental conditions
Bioaccumulation Potential: Not expected to persist or bioaccumulate
Mobility in Soil: Likely to have low mobility based on water solubility and ionic nature
Other Ecological Effects: No significant effects identified in laboratory or field studies
Additional Notes: Pharmaceutical residues should be prevented from entering waterways
Waste Disposal Methods: Dispose of in compliance with local, regional, and national regulations for pharmaceutical waste
Contaminated Packaging: Dispose of used, empty packaging as controlled waste according to official instructions
Special Precautions: Avoid generating dust during disposal, do not flush into surface water or sewer systems
UN Number: Not regulated for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified as dangerous goods under international transport regulations
Packing Group: Not assigned
Special Precautions for Transport: Avoid direct sunlight and moisture during transport, store securely to prevent package damage
Safety, Health, and Environmental Regulations: Not listed under major chemical inventories such as TSCA, EINECS/ELINCS, or DSL
Pharmaceutical Regulations: Subject to specific regulations for drugs and medical substances by agencies such as FDA, EMA, or national regulatory authorities
Workplace Regulations: Use and handling may be regulated under occupational health and safety laws in some regions
Labeling Requirements: Follows pharmaceutical labeling rules where applicable
Other Regulation: Not subject to major transport, environmental, or international restriction
