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Material Safety Data Sheet (MSDS) for Calcium Gluconate

Identification

Product Name: Calcium Gluconate
Chemical Formula: C12H22CaO14
CAS Number: 299-28-5
Relevant Uses: Used in medicine to treat calcium deficiencies, in laboratories, and food-grade applications
Manufacturer/Supplier: Information varies by origin; consult supplier documentation
Contact Information: Emergency contact often listed on supplier document for quick access
Synonyms: Gluconic acid, calcium salt

Hazard Identification

Classification: Not classified as hazardous under OSHA HazCom or GHS standards
Main Hazards: Dust may cause mechanical irritation to eyes, skin, and lungs; large quantities may disrupt electrolyte balance in the body; ingestion of excessive amounts can cause gastrointestinal discomfort
Pictogram: Typically not required for non-hazardous substances, but always verify with supplier
Label Elements: No significant symbols or precautionary statements required beyond basic hygiene and protective advice

Composition / Information on Ingredients

Ingredient: Calcium Gluconate
Chemical Identity: Calcium Gluconate (CAS: 299-28-5) nearly pure form in most grades
Concentration: Typically >98% by weight
Impurities: Trace water, possible sodium or other gluconates in minor quantities depending on source
Additives: Pharmaceutical grade may contain stabilizers or water of hydration

First Aid Measures

Inhalation: Move to fresh air; get medical attention if coughing or difficulty breathing persists
Skin Contact: Wash affected skin thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse with running water for at least 15 minutes; seek medical help if irritation persists
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical advice if large amounts have been swallowed or if symptoms like nausea, vomiting, or abdominal cramps develop
Note to Physician: Monitor blood calcium levels in case of large ingestion or symptoms of hypercalcemia

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide—address combustion of packaging
Hazardous Byproducts: Product itself does not ignite; decomposition beyond 200°C may release harmful gases like carbon oxides
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Special Instructions: Avoid breathing dust and fumes; contain and control contaminated run-off water to keep out of drains

Accidental Release Measures

Personal Precautions: Wear dust mask, gloves, goggles; minimize dust generation and inhalation
Environmental Precautions: Prevent run-off into sewers or natural waterways as high concentrations may disrupt aquatic ecosystems
Clean-Up Methods: Sweep up material, collect in sealed containers for disposal; use damp cloth to collect fine residual dust
Disposal of Waste: Place material in tightly closed containers for proper disposal according to local regulations

Handling and Storage

Handling: Use with adequate ventilation to prevent dust formation; avoid inhalation and contact with eyes or skin
Hygiene Practices: Wash hands thoroughly after handling, do not eat or drink in work area
Storage Conditions: Keep container sealed when not in use; store in dry, cool, well-ventilated location
Incompatibilities: Avoid strong acids and oxidizers that can decompose the product
Recommended Shelf Life: Store at room temperature, away from moisture, to extend stability

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established specifically for calcium gluconate; use generic dust exposure guidelines for nuisance particulates (e.g., OSHA PEL 15 mg/m3 total dust)
Engineering Controls: Local exhaust ventilation or dust collection recommended for large-scale use
Personal Protective Equipment: Dust mask or respirator for airborne exposure, safety goggles, laboratory coat, impervious gloves
Other Precautions: Provide eye wash stations and emergency showers in areas with risk of exposure to dust

Physical and Chemical Properties

Appearance: White, odorless powder or granules
Physical State: Solid at room temperature
Melting Point: Decomposes without melting (above 200°C)
Solubility in Water: Soluble (3% at room temperature)
pH (solution): pH of 10% solution approximately 6–8
Specific Gravity: 1.5–1.75
Odor: None
Vapor Pressure: Not applicable (non-volatile)
Boiling Point: Not applicable
Other Properties: Stable under recommended conditions with slight hygroscopic nature

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Materials to Avoid: Strong acids (may produce gluconic acid and calcium salt precipitation), strong oxidizers
Hazardous Decomposition Products: Decomposes at high temperature to release carbon dioxide, carbon monoxide
Polymerization: Does not occur
Reactivity: Low reactivity under normal conditions; hydrolyzes in acidic solutions

Toxicological Information

Acute Toxicity: Low toxicity; oral LD50 in rats > 10,000 mg/kg
Chronic Effects: Repeated excessive ingestion can lead to hypercalcemia with symptoms like muscle weakness, confusion, kidney stones
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Irritation: Dust may cause mild irritation to eyes, skin, and respiratory tract
Carcinogenicity: Not listed by IARC, NTP, or OSHA as carcinogen
Other Data: No evidence of mutagenicity or reproductive toxicity at usual exposure levels

Ecological Information

Ecotoxicity: Not expected to be toxic to aquatic organisms at typical concentrations; large spills may affect water hardness and disrupt aquatic balance
Persistence and Degradability: Biodegradable; breaks down into natural components
Bioaccumulation: Low potential; readily excreted by living organisms
Mobility in Soil: Soluble in water, may move through soil, but doesn’t persist
Other Effects: Monitor excessive release to prevent disturbance of water chemistry

Disposal Considerations

Waste Disposal: Dispose of in compliance with local, regional, and national laws; small amounts may be washed away with excess water, but avoid bulk disposal through drains
Container Disposal: Triple rinse and offer recycling if available or dispose of as solid waste
Precautions: Prevent contamination of groundwater or waterways
Recommended Practice: Use licensed waste contractor for non-routine or large quantities

Transport Information

UN Number: Not regulated
Transport Hazard Class: Not classified as hazardous for transport
Packaging Requirements: Use sealed, labeled containers to avoid accidental release of dust during transit
Shipping Name: Calcium Gluconate
Environmental Hazards: None applicable under transport regulations
Special Precautions: Protect from moisture, excessive heat during shipping

Regulatory Information

U.S. Regulations: Not specifically listed as hazardous by OSHA, TSCA listed
EU Regulations: REACH registered, not classified as dangerous
Canadian Regulations: DSL/NDSL listed
Other Country Regulations: Vary by location; not usually subject to export/import restrictions
SDS Requirements: Prepared following GHS and regional hazard communication rules
Labeling: Not required to use hazard symbols under most regulations; basic identification and hygiene precaution labeling suggested