© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Butenafine Hydrochloride
Chemical Name: 1-Butyl-4-[4-phenyl-2-(methylthio)butyl]-1-piperidine hydrochloride
Synonyms: Butenafine HCl, Mentax
CAS Number: 92323-29-0
Recommended Use: Topical antifungal agent
Manufacturer/Supplier: [Company Name, Address, Contact Information]
Emergency Phone Number: [Insert number for emergencies]
Classification: Not classified as hazardous under GHS criteria for pure substance; powder form can cause irritation to eyes, skin, and respiratory tract.
Signal Word: Caution
Hazard Statements: May cause mild skin and eye irritation, harmful if swallowed in large quantities, dust may cause respiratory irritation.
Precautionary Statements: Avoid breathing dust, use with adequate ventilation, wash thoroughly after handling, wear protective gear.
Chemical Identity: Butenafine Hydrochloride
CAS Number: 92323-29-0
Concentration: 100% (pure active ingredient)
Molecular Formula: C23H27N•HClS
Impurities (if any): Trace organic solvents, residuals below detection thresholds
Relevant Impurities: No known relevant impurities classified as hazardous at supplied purity
Inhalation: Move person to fresh air. Seek medical attention if cough or breathing difficulties appear. Remove any tight clothing.
Skin Contact: Rinse thoroughly with water and mild soap. Remove contaminated clothing. Seek medical attention if irritation develops.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Hold eyelids open. Seek medical attention if irritation persists.
Ingestion: If swallowed, rinse mouth with water. Do not induce vomiting. Seek immediate medical attention for large quantities.
Most Important Symptoms and Effects: Mild irritation, potential allergic reaction for sensitized individuals.
Suitable Extinguishing Media: Use dry chemical, CO2, or water spray. Foam can also be used.
Specific Hazards Arising from Chemical: Combustion can produce toxic fumes of carbon monoxide, carbon dioxide, hydrochloric acid, and sulfur oxides.
Fire-Fighter Protective Equipment: Self-contained breathing apparatus and full protective clothing recommended.
Further Information: Cool exposed containers with water spray to prevent rupture.
Personal Precautions: Avoid creating dust, ventilate affected area, evacuate non-essential personnel, avoid contact with skin and eyes.
Emergency Procedures: Use recommended personal protective equipment. Contain spill to prevent environmental release.
Containment and Cleanup: Scoop up material with non-sparking tools. Avoid generating airborne particulates. Place in chemical waste container for disposal following local regulations. Wash spill area thoroughly.
Handling: Handle with gloves, goggles, and protective clothing. Avoid dust generation. Use only in well-ventilated areas.
Safe Storage Conditions: Keep container tightly closed in a cool, dry, and well-ventilated location. Store away from sources of ignition and incompatible materials.
Storage Incompatibilities: Separate from acids, oxidizers, and combustible materials.
Occupational Exposure Limits: No specific exposure limit established for this compound. Handle as a pharmaceutical active.
Engineering Controls: Use laboratory fume hood, local exhaust ventilation to prevent airborne exposure.
Personal Protective Equipment: Chemical-resistant gloves, lab safety goggles, protective lab coat. Respiratory protection if dust generation cannot be controlled.
Environmental Controls: Prevent run-off into drains, soil, or waterways.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH (1% solution): 4.0 to 5.0
Melting Point/Range: 227-232°C
Boiling Point/Range: Not applicable
Flash Point: Not applicable
Evaporation Rate: Not determined
Solubility: Soluble in ethanol, slightly soluble in water
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: 1.23 g/cm3 (estimate)
Partition Coefficient (log P): 2.5–3.0
Auto-ignition Temperature: Not determined
Chemical Stability: Stable under recommended storage conditions. May degrade under high humidity and temperature.
Reactivity: Reacts with strong oxidizing agents, acids, strong bases.
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, hydrogen chloride generated at extreme heat.
Polymerization: Will not occur.
Conditions to Avoid: Exposure to moisture, incompatible substances, open flames, and high temperatures.
Likely Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg (low acute toxicity); Inhalation LC50 (rat): not available
Skin Irritation: Mild irritation possible, especially on prolonged exposure
Eye Irritation: May cause irritation, redness, tearing
Chronic Toxicity: Repeated overexposure may lead to skin sensitization; insufficient data for carcinogenicity, genotoxicity, or reproductive toxicity at therapeutic doses
Symptoms of Overexposure: Irritation, nausea, headache, allergic reactions
Ecotoxicity: Data limited; not expected to be acutely toxic to aquatic life at low concentrations. May be harmful in large quantities.
Persistence and Degradability: Expected to degrade slowly in the environment; not classified as persistent based on structure.
Bioaccumulative Potential: Based on partition coefficient, low to moderate potential for bioaccumulation.
Mobility in Soil: Low water solubility limits mobility; adheres to soil particles.
Other Adverse Effects: Avoid uncontrolled release; no specific data on interaction with wastewater or treatment plants.
Waste Disposal Methods: Dispose of material according to national, state, and local environmental regulations as pharmaceutical waste.
Contaminated Packaging: Wash thoroughly before recycling or disposal; triple rinse and offer for recycling if possible.
Special Precautions for Disposal: Do not release to sewer or environment; avoid incineration without scrubbers to limit pollutant generation.
UN Number: Not classified as dangerous for transport under UN, ADR, IATA, IMDG codes
Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None
Special Precautions: Transport in sealed, labeled containers. Protect from moisture, rough handling, and extreme temperatures during shipping.
TSCA (USA): Listed
REACH (EU): Not individually registered as of latest update, used primarily as a pharmaceutical substance
OSHA Status: Not hazardous as per 29 CFR 1910.1200
WHMIS (Canada): Not classified as controlled
DSL/NDSL (Canada): Listed on DSL
EINECS/ELINCS (Europe): Not listed separately as medicinal ingredient
Other Local Regulations: Product use regulated under pharmaceutical product legislations; consult local health and safety regulations for workplace handling and waste
