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Product Name: Bupropion Hydrochloride
Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Synonyms: Wellbutrin, Zyban
Molecular Formula: C13H18ClNO•HCl
Molecular Weight: 276.2 g/mol
CAS Number: 31677-93-7
Recommended Use: Pharmaceutical active ingredient, research chemical
Supplier: Refer to manufacturer or distributor label for contact details
Emergency Contact: Refer to manufacturer’s emergency contact
Hazard Classification: Acute Toxicity (Oral, Category 4), Eye Irritation (Category 2A), Reproductive Toxicity (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, suspected of damaging fertility or the unborn child
Precautionary Statements: Wear protective gloves, eye protection, and a dust mask. Wash hands thoroughly after handling. Avoid release to the environment.
Potential Health Effects: Irritation to eyes and skin, potential for neurologic effects at high exposures, may affect CNS
Environmental Hazards: Toxic to aquatic organisms with long-lasting effects
Chemical Name: Bupropion Hydrochloride
CAS Number: 31677-93-7
Concentration: 98-100%
Impurities: Minor organic synthesis by-products, total impurities less than 2%
Other Ingredients: None reported in pure substance
Inhalation: Move person to fresh air, keep at rest; seek medical attention if symptoms develop.
Skin Contact: Wash affected area with soap and water; remove contaminated clothing; consult healthcare provider if irritation persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do; seek medical attention.
Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel; seek immediate medical advice.
Most Important Symptoms and Effects: Irritation, headache, dizziness, possible seizures at high doses
Notes to Physician: Provide symptomatic and supportive treatment; monitor vital signs and neurological function
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide.
Unsuitable Extinguishing Media: Strong water jets.
Specific Hazards: Emits toxic fumes of hydrogen chloride, nitrogen oxides, and carbon monoxide under fire conditions.
Protective Equipment: Firefighters need full protective clothing and self-contained breathing apparatus.
Special Precautions: Avoid release of contaminated runoff from fire control to the environment
Personal Precautions: Wear gloves, lab coat, respirator, and eye protection.
Environmental Precautions: Avoid discharge to drains or surface waters
Spill Cleanup Methods: Sweep up dry material, avoid generating dust. Place residue in a sealed container. Wash the spill site with water and detergent following clean-up. Dispose of waste in accordance with local regulations
Precautions for Safe Handling: Avoid inhalation of dust, avoid skin and eye contact. Use in well-ventilated area, protect from moisture exposure.
Hygiene Measures: Wash hands before breaks, after handling, and at end of work.
Storage Conditions: Store in a tightly closed container, away from light, moisture, and incompatible substances.
Incompatibilities: Strong oxidizers, strong acids, bases
Storage Temperature: Store between 15-30°C (59-86°F)
Occupational Exposure Limits: No specific exposure limits have been established for bupropion hydrochloride.
Engineering Controls: Use local exhaust ventilation or work in a fume hood when dealing with large quantities.
Personal Protective Equipment: Chemical resistant gloves, safety goggles, NIOSH-approved dust mask or respirator, laboratory coat.
Environmental Exposure Controls: Procedures to avoid contamination of air, water, and soil outside of the working area
Appearance: White to off-white crystalline powder
Odor: Odorless or slight amine-like smell
Odor Threshold: Not determined
pH: 3–4.5 (1% aqueous solution)
Melting Point: 233–234°C
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water, methanol; very slightly soluble in chloroform
Partition Coefficient (log P): -0.1 (estimated for hydrochloride form)
Vapor Pressure: Not applicable (solid at room temperature)
Density: Approximately 1.1–1.2 g/cm³
Other Properties: Stable under recommended storage conditions, non-volatile solid
Chemical Stability: Stable under normal conditions, away from moisture and light.
Reactivity: Not reactive under normal handling and storage conditions.
Incompatible Materials: Strong acids, strong bases, oxidizers.
Hazardous Decomposition Products: May produce carbon oxides, hydrogen chloride, nitrogen oxides when subjected to heat or fire.
Hazardous Polymerization: Not known to occur
Conditions to Avoid: High temperatures, direct sunlight, and humid environments
Acute Toxicity: Oral LD50 (rat): 340–520 mg/kg
Skin Corrosion/Irritation: May cause mild skin irritation
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Sensitization: Not classified as a respiratory sensitizer
Specific Target Organ Toxicity: May cause central nervous system effects, seizures at high doses and with overdose
Additional Effects: At therapeutic doses, neurological effects (insomnia, agitation, tremor), potential for allergic reactions
Carcinogenicity/Mutagenicity: Not identified as carcinogenic or mutagenic in animal studies
Reproductive Toxicity: Animal studies suggest potential risk to reproduction and fetal development
Other Information: Long term exposure not well studied; use caution if pregnant or breastfeeding
Ecotoxicity: May be harmful to aquatic life with long lasting effects; toxicity data limited
Persistence and Degradability: Not rapidly biodegradable; risk of persistence in aquatic environments
Bioaccumulative Potential: Low likelihood of significant bioaccumulation (low partition coefficient)
Mobility in Soil: Moderate mobility in the environment, risk for contamination of water sources
Other Effects: No known significant effect or critical hazards to the ozone layer or wildlife with typical laboratory quantities
Waste Treatment Methods: Collect and containerize material for chemical waste disposal.
Disposal of Product: Dispose of through licensed hazardous waste disposal contractor.
Disposal of Packaging: Triple rinse empty containers, dispose in accordance with local, regional, and national regulations.
Environmental Precautions: Do not release into drains, water courses, or soil
UN Number: Not classified as a dangerous good for transport per ADR, IATA, IMDG.
Proper Shipping Name: Bupropion Hydrochloride
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions for User: Secure containers and protect from physical damage during transport; follow internal policies for handling and shipping pharmaceutical actives
US Regulations: Not listed as a controlled substance by the US DEA; prescription pharmaceutical (FDA). May appear in TSCA inventory as a research chemical.
EU Regulation: Classified as medicinal product, not subject to REACH registration under normal pharmaceutical use. Not on ECHA SVHC list.
Other Global Listings: Verify status under individual country pharmaceutical and chemical control laws.
Labeling Requirements: Hazard, precautionary, and product-specific statements required on all containers.
Workplace Regulation: Handle according to OSHA, NIOSH, and related guidelines for pharmaceutical actives.
