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Product Name: Bumetanide
Chemical Name: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Synonyms: Bumex
CAS Number: 28395-03-1
Recommended Use: Diuretic medication, research purposes
Manufacturer: Contact details available from supplier; confirm with latest supplier SDS
Emergency Contact: Refer to company protocol or local poison control resources
Classification: May cause skin and eye irritation; not classified as flammable; toxic if ingested in significant quantities
GHS Label Elements: Warning, irritant pictogram
Hazard Statements: Causes irritation to eyes, skin, and respiratory tract; harmful if swallowed; potential allergen risk
Precautionary Statements: Avoid contact with skin and eyes; use in ventilated area; avoid inhalation of dust; use appropriate personal protective equipment (PPE)
Chemical Formula: C17H20N2O5S
Active Ingredient: Bumetanide
Concentration: 100% for pure chemical; refer to formulation specifics
Impurities: Information available from manufacturer; potentially present in minor concentrations
Inhalation: Remove person to fresh air; seek medical attention if symptoms persist or develop
Skin Contact: Rinse with water; remove contaminated clothing; seek attention for irritation or allergic reactions
Eye Contact: Flush eyes with water for at least 15 minutes; seek medical support if irritation remains
Ingestion: Do not induce vomiting; rinse mouth; seek immediate medical advice
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, or foam; select agent based on surrounding fire
Special Protective Equipment: Use self-contained breathing apparatus and full protective clothing
Hazards During Fire: Decomposition generates irritating and toxic gases such as nitrogen oxides, sulfur compounds, carbon oxides
Additional Guidance: Prevent fire runoff from contaminating surface and ground water
Personal Precautions: Wear respirator, gloves, and protective clothing; avoid generating dust
Environmental Precautions: Do not allow to enter drains or watercourses
Cleanup Methods: Sweep up spill with minimal dust; place in secure container; wash spill area with suitable cleaning agent
Disposal: Follow chemical waste protocols; consult local regulations
Handling: Work in well-ventilated environment; avoid direct contact with powder and prolonged exposure
Hygiene Measures: Wash hands thoroughly after handling; avoid contact with eyes and skin
Storage Conditions: Keep container tightly closed and stored in cool, dry place; protect from light and moisture; segregate from incompatible materials like strong oxidizers and acids
Packing Materials: Use shatterproof, sealed, chemical-resistant packaging
Engineering Controls: Use local exhaust ventilation or work in fume hood
Personal Protection: Chemical-resistant gloves, safety goggles, lab coat or apron; use respirator for dust
Occupational Exposure Limits: Not established; minimize exposure as a precaution
Environmental Control: Monitor and contain spills to prevent release into ecosystem
Appearance: White or off-white crystalline powder
Odor: Odorless or slight characteristic odor
Molecular Weight: 364.42 g/mol
Melting Point: 202-204°C
Solubility in Water: Slightly soluble; more soluble in organic solvents like ethanol or DMSO
pH: Not readily available; slight acidity possible in solution
Boiling Point: Not applicable under ambient pressure; decomposes
Vapor Pressure: Negligible at ambient conditions
Chemical Stability: Stable under recommended storage conditions; moisture sensitive
Reactivity: Does not react under normal process conditions
Incompatibility: Avoid strong oxidizing agents, acids, alkalis
Decomposition: Emits noxious fumes such as nitrogen oxides, sulfur oxides, carbon compounds at high temperatures
Polymerization: Does not polymerize
Acute Toxicity: LD50 (oral, rat) approximately 100-300 mg/kg
Chronic Effects: Prolonged exposure may harm kidney, cause skin reactions, or sensitize skin
Routes of Exposure: Inhalation, skin, ingestion
Symptoms: Irritation, nausea, vomiting, possible drowsiness or confusion in larger doses
Carcinogenicity: No clear evidence in current literature; refer to latest studies for updates
Ecotoxicity: Harmful to aquatic life with long-lasting effects
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulation Potential: Low, but monitor for long-term presence in water bodies
Mobility in Soil: Limited mobility due to low solubility
Other Ecological Advice: Do not dispose of in sewage or waterways; restrict environmental release
Waste Disposal Method: Treat as hazardous chemical waste; follow local, regional, national, and international guidelines
Contaminated Packaging: Dispose of as hazardous waste; decontaminate if possible or use certified waste contractor
Recommended Treatment: Incineration in approved facility with gas scrubbing system
Potential Health Hazards: Avoid any method that may distribute dust or fumes; use PPE
UN Number: Not assigned for non-commercial bulk transport; check current regulations
Proper Shipping Name: Chemical, n.o.s. (not otherwise specified)
Hazard Class: Not classified as hazardous for transport under most regulations
Packing Group: Not regulated for routine transport
Special Precautions: Prevent package breakage and spillage; transport in compliant chemical containers
Label Requirements: Caution label for laboratory reagents recommended
Inventories: Listed in major global chemical inventories
Workplace Regulation: Subject to occupational exposure standards in health care and research settings
Labeling Requirements: Comply with GHS for irritation and toxicity
Restrictions: Prescription-only status in pharmaceutical use; training required for handlers
Other Regulation: Handle according to local, regional, and national guidelines; R&D use must follow institutional biosafety procedures
