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Chemical Name: Brucine Sulfate
Common Names: Brucine Sulphate, Brucinium Sulfate
Chemical Formula: C46H56N4O10·H2SO4
Physical Appearance: White or off-white crystalline powder; bitter taste
Intended Use: Used as a reagent in labs, research activities, and possibly in trace toxicology screening
Odor: Odorless
Solubility: Soluble in water, partly soluble in ethanol
Other Identifiers: Substance typically purchased for analytical, research purposes only
Main Health Hazards: Toxic if inhaled, swallowed, or absorbed through the skin; causes irritation to eyes, skin, and respiratory system; neurotoxic in high doses
GHS Classification: Acute toxicity (oral, dermal, inhalation); Hazardous to aquatic environments
Hazard Statements: Exposure may result in convulsions, muscle twitching, cardiac effects, or death. Risk increases if not handled with suitable protection.
Pictograms: Skull and crossbones for acute toxicity, exclamation mark for irritant effects
Chronic Exposure: Repeated exposure could damage nervous system
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Substance: Brucine Sulfate
CAS Number: 4845-38-7
Purity: Usually over 98% unless mixed or diluted for specific applications
Additives/Impurities: May contain trace moisture depending on storage and air exposure
Inhalation: Remove responsible person to fresh air, loosen tight clothing, seek immediate medical help
Splash in Eye: Flush eyes with running water for 15-20 minutes; get prompt medical attention
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with soap and water, consult Poison Control
Ingestion: Do not induce vomiting; rinse mouth with water; seek urgent medical advice
Rescue Advice: Show doctor or first responders the label or this information
Suitable Extinguishing Media: Water spray, dry powder, CO2 extinguishers, or foam
Specific Hazards Relating to Fire: During a fire, toxic fumes (nitrogen oxides, carbon oxides, sulfur oxides) may form
Protective Equipment: Use self-contained breathing apparatus and full protective gear
Suggestions for Fire Response: Avoid breathing smoke, try to contain runoff water used for firefighting
Spill Control: Evacuate area, ventilate space; avoid contact with substance
Personal Precautions: Wear gloves, goggles, lab coat, and a dust mask or respirator
Cleanup Procedures: Collect spilled material using scoops and damp wipes; dispose in a sealed container
Avoid Wash Water Runoff: Prevent entry into drains or water systems
Handling: Keep containers tightly closed, minimize dust, always work in a fume hood
Avoid Actions: Never eat, drink, or smoke while handling; avoid inhaling or direct skin contact
Storage: Store locked up in dry, well-ventilated space away from food, incompatible materials, acids, combustibles
Temperature Range: Room temperature, away from heat sources
Exposure Limits: No official OSHA or ACGIH limits for Brucine Sulfate, but treat as highly hazardous
Engineering Controls: Use fume hoods, local exhaust, splash shields for routine work
Personal Protection: Chemical-resistant gloves (such as nitrile), safety goggles, lab coat, and face protection for splash risk
Hygiene Advice: Wash hands after use, remove contaminated garments before leaving lab
Physical State: Solid (powder or crystal)
Color: White to off-white
Melting Point: 178–180°C (decomposes)
Solubility: Readily dissolves in water; less soluble in organic solvents
Odor: No detectable odor
Other Notes: May decompose on prolonged exposure to air and light
Chemical Stability: Stable under standard handling conditions; slowly degrades with exposure to light or air
Reactive Combinations: Strong oxidizers, acids, or bases accelerate breakdown and may cause hazardous byproducts
Decomposition Products: Toxic fumes possible, notably carbon monoxide, oxides of nitrogen and sulfur
Routes of Entry: Oral, inhalation, dermal, ocular
Acute Toxicity: Highly toxic; may cause convulsions, respiratory paralysis, cardiac arrest with accidental exposure
Symptoms of Poisoning: Nausea, muscle twitches, confusion, agitation, seizures
Long-Term Risk: Chronic exposure damages nervous system, possible carcinogenic effect unconfirmed in humans but not ruled out
Noted Incidents: Brucine is related to strychnine in toxicity; poisoning cases in literature highlight extreme danger
Environmental Impact: Highly toxic to aquatic organisms, possible bioaccumulation in water bodies
Persistence: Not rapidly biodegradable; may persist in surface and groundwater
Spill Concern: Prevent release into environment; containment required during any spill or waste process
Regulatory Restrictions: Some regions restrict discharge or disposal into waterways
Waste Disposal: Treat as hazardous chemical waste, not suitable for municipal trash or drains
Destruction Methods: Professional incineration preferred; never pour down sink
Container Handling: Decontaminate, label, and send to chemical waste facility
Legal Requirements: Follow stringent local, state, or national regulations for toxic wastes
General Rules: Subject to strict regulatory transport rules as a toxic substance
Packing Group: Toxic Substances, regulated during shipping, not safe for transport in passenger luggage or regular postal services
Special Precautions: Package securely, clear hazard labeling, avoid rough handling
International Listings: Covered under various poison and controlled substance regulations
National Restrictions: Many countries restrict non-research use of brucine and its salts
Workplace Rules: Restricted access in labs; documentation and licensing needed for purchase or large-scale use
Worker Safety Standards: Employers must train staff, supply protective gear, maintain chemical inventories
