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Product Name: Brucine Hydrochloride
Chemical Name: 2,3-dimethoxystrychnidin-10-one hydrochloride
Synonyms: Brucine Monohydrochloride
CAS Number: 5892-10-4
Molecular Formula: C23H27N2O4.HCl
Molecular Weight: 430.93 g/mol
Intended Use: Laboratory chemical, research and analysis
Supplier Contact: [Company Contact Information]
Emergency Phone: [Emergency Number]
GHS Classification: Acute Toxicity – Oral (Category 2); Skin Irritation (Category 2); Eye Irritation (Category 2); Aquatic Acute Toxicity (Category 1)
Pictograms: Skull and crossbones, Exclamation mark, Environment
Signal Word: Danger
Hazard Statements: Fatal if swallowed; Causes skin irritation; Causes serious eye irritation; Very toxic to aquatic life
Precautionary Statements: Avoid skin and eye contact; Avoid release to the environment; Wear suitable protective equipment during handling; Wash hands thoroughly after use
Potential Health Effects: Ingestion can cause severe intoxication; Contact with skin or eyes may lead to irritation or lasting injury; Exposure routes include ingestion, inhalation, and dermal absorption
Chemical Component: Brucine Hydrochloride
Concentration: ≥98%
Impurities: Trace levels of unreacted sources or by-products
Other Components: None reported as hazardous under current regulations
CAS Registry Number: 5892-10-4
Inhalation: Move to fresh air; seek medical attention if symptoms develop; administer artificial respiration if breathing stops.
Skin Contact: Remove contaminated clothing; rinse affected skin with plenty of water for at least 15 minutes; consult a physician.
Eye Contact: Rinse eyes immediately with water for at least 15 minutes, lifting upper and lower eyelids; seek medical attention.
Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical intervention.
Acute Symptoms: Muscle spasms, convulsions, central nervous system effects, gastrointestinal distress
Advice for Doctor: Treat symptomatically, monitor respiratory and cardiovascular function, manage seizures as clinically indicated
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, or water spray
Specific Hazards: May produce toxic fumes if exposed to fire, including hydrogen chloride, nitrogen oxides, and carbon oxides
Protective Equipment: Self-contained breathing apparatus and full firefighting protective clothing
Special Procedures: Evacuate area; prevent run-off from entering drains or watercourses; cool containers with water spray to prevent pressure build-up
Explosion Risk: Product not classified as flammable; fine powder may form mixtures with air, increasing risk if exposed to ignition sources
Personal Precautions: Evacuate unnecessary personnel; use recommended personal protective equipment including gloves, goggles, and a lab coat; avoid inhalation and contact
Environmental Precautions: Prevent spillage from entering drains, soil, or water bodies
Clean Up Methods: Collect spilled material using an inert absorbent; transfer to a suitable closed container for disposal; ventilate area and cleanse surfaces with soapy water
Secondary Hazards: Contaminated materials should be handled according to disposal considerations to avoid secondary contamination
Safe Handling: Use in a fume hood or well-ventilated area; avoid formation of dust or aerosols; do not eat, drink, or smoke during use
Technical Measures: Ground and bond containers when transferring powders; use explosion-proof ventilation
Storage Conditions: Store in a tightly sealed container; keep in a cool, dry, well-ventilated area; protect from light and incompatible substances
Segregation from Incompatibles: Keep away from oxidizers, strong acids, and strong bases; segregate from food and animal feed
Special Requirements: Follow local, regional, and national storage codes for toxic chemicals
Occupational Exposure Limits: No established limits; handle as a hazardous substance
Engineering Controls: Work in fume hood; implement mechanical exhaust where appropriate
Eye Protection: Safety goggles with side shields
Skin Protection: Protective gloves (nitrile or better), lab coat or chemical-resistant apron
Respiratory Protection: Use approved respirator if allowable airborne concentrations are exceeded or if ventilation is inadequate
Hygiene Measures: Wash hands before breaks and after using product; remove contaminated clothing and wash before reuse
Environmental Controls: Minimize escape into environment; follow spill response and disposal procedures carefully
Appearance: White crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH (solution): Not available
Melting Point/Freezing Point: 264–266°C (uncorrected, decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not determined
Flammability: Not classified as flammable
Vapor Pressure: Negligible
Vapor Density: Not available
Relative Density: Not determined
Solubility: Soluble in water, soluble in ethanol
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 264°C
Viscosity: Not applicable
Molecular Weight: 430.93 g/mol
Reactivity: Product remains stable under recommended storage conditions
Chemical Stability: Stable when stored under normal temperature and pressure
Conditions to Avoid: Excessive heat, moisture, exposure to light
Incompatible Materials: Strong oxidizers, acids, and alkalies
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, and carbon dioxide upon thermal decomposition
Possibility of Hazardous Reactions: May react with strong oxidizing agents; no hazardous polymerization expected
Acute Toxicity: Highly toxic; estimated oral LD50 (rat) 30 mg/kg
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms: Convulsions, muscle rigidity, salivation, respiratory distress, tremor, possible seizure or coma
Skin Corrosion/Irritation: Causes skin irritation on contact
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Sensitization: Not classified
Skin Sensitization: Not classified
Chronic Toxicity: Long-term effects include potential neurotoxicity
Carcinogenicity: Not listed by IARC, NTP, OSHA
Germ Cell Mutagenicity: No data available
Reproductive Toxicity: Not well documented
Target Organs: Central nervous system, neuromuscular pathways
Additional Toxicological Data: No evidence for cumulative toxicity under laboratory exposure conditions
Ecotoxicity: Very toxic to aquatic life; acute and chronic effects expected in aquatic environments
Persistence and Degradability: Limited data; compound predicted persistent in soil and water environments
Bioaccumulative Potential: Potential for bioaccumulation exists based on structure and physical properties
Mobility in Soil: Expected low to moderate mobility due to water solubility
Other Adverse Effects: Environmental release can result in secondary poisoning in aquatic and terrestrial organisms; minimize environmental discharge whenever possible
Waste Disposal Methods: Collect and label all waste material clearly; dispose as hazardous waste in accordance with local and national regulations
Contaminated Containers: Rinse thoroughly before disposal; dispose of under existing hazardous waste guidelines
Precautions: Prevent container breakage or dispersal of dust in transit; do not discharge into environment, drainage systems, or natural bodies of water
Special Instructions: Consult with a licensed professional waste disposal service to handle large amounts or accidental releases
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (includes Brucine Hydrochloride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant; label accordingly
Special Precautions for User: Ensure containers are correctly labelled; avoid transport with foodstuffs or feeds; follow transport regulations for dangerous goods
Regulatory References: IMDG, IATA, DOT guidelines apply
Classification: Subject to significant national and international regulations as a highly toxic compound
Labelling Requirements: Skulls and crossbones, environmental, health hazard pictograms required
Inventory Status: Listed on TSCA, EINECS, and other chemical inventories
Specific Legislation: Subject to regulations under OSHA Hazard Communication Standard (29 CFR 1910.1200), European Directives for Classification, Packaging, and Labelling of Dangerous Substances
SARA Title III (Sections 302, 304, 311/312, 313): Not listed
REACH Status: Substance of very high concern consideration due to toxicity
Other Information: Handle in strict accordance with regulatory guidelines; users must follow training for handling acutely toxic materials
