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Product Name: Bromocriptine Mesylate
Chemical Formula: C32H40BrN5O5S
Synonyms: 2-Bromo-ergocryptine methanesulfonate
CAS Number: 22260-51-1
Intended Use: Used primarily in pharmaceuticals for the treatment of Parkinson’s disease, hyperprolactinemia, and certain types of pituitary tumors
Supplier Information: Pharmaceutical manufacturers, research chemical providers
Emergency Contact: Refer to local regulations and supplier emergency numbers
Hazard Classification: Toxic if swallowed; possible reproductive toxin; may cause allergic skin reaction
Label Elements: Danger signal word, skull and crossbones pictogram, exclamation mark
Potential Health Effects: Acute exposure can cause headaches, dizziness, nausea, vomiting, abdominal cramps, fatigue, cardiac disturbances
Environmental Hazards: Harmful to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing dust; wash thoroughly after handling; use personal protective equipment as required; avoid release into environment
Substance: Bromocriptine Mesylate
Purity: Typically above 98% for pharmaceutical grade
Impurities: Minimal residual solvents, ergoline derivatives
Other Components: No significant excipients or complementary substances in pure form
Molecular Weight: 750.66 g/mol
Inhalation: Remove person to fresh air. If breathing is difficult, oxygen may be given; medical attention recommended.
Skin Contact: Remove contaminated clothing; wash skin gently and thoroughly with soap and water; seek medical advice if irritation or allergic reaction persists.
Eye Contact: Rinse with plenty of water for at least 15 minutes; keep eyelids open; seek immediate eye specialist consultation.
Ingestion: Rinse mouth, do not induce vomiting; drink plenty of water; immediate medical attention required.
Most Important Symptoms: Nausea, dizziness, extremity tingling, respiratory compromise, hypersensitive reactions
Advice for Medical Personnel: Provide symptomatic and supportive care
Suitable Extinguishing Media: Small fires can be controlled by dry chemical, water spray, carbon dioxide, or foam
Specific Hazards: Emits toxic fumes of carbon oxides, nitrogen oxides, hydrogen bromide, sulfur oxides upon burning
Special Procedures: Wear self-contained breathing apparatus and full protective clothing; avoid inhalation of combustion materials
Explosion Data: Not considered explosive, but gently heat; avoid dust accumulation in closed spaces
Firefighting Equipment: Chemical resistant gloves, boots, goggles, positive pressure breathing apparatus
Personal Precautions: Evacuate area, avoid contact with skin, eyes, and clothing; use personal protective equipment including gloves, goggles, laboratory coat, mask
Environmental Precautions: Prevent substance from entering drains, water sources, or soil
Cleanup Methods: Carefully sweep, scoop, or vacuum spill material without raising dust; place in suitable closed container for legal disposal
Disposal: Dispose in accordance with regional regulations and company practices for pharmaceutical waste
Decontamination: Wipe surfaces with damp cloth and appropriate cleaning agent
Precautions for Safe Handling: Avoid all direct contact with eyes, skin, clothing; prevent formation of dust; handle only in well-ventilated areas and use approved safety systems
Hygienic Measures: Wash hands after use, do not eat or drink in the work area; remove contaminated clothing immediately
Storage Conditions: Store in tightly closed containers in cool, dry, well-ventilated location away from sunlight, oxidizers, strong acids, strong bases
Incompatibilities: Keep apart from oxidizing agents, strong acids, bases
Storage Temperature: 2-8°C recommended for long-term stability; protect from moisture and physical damage
Exposure Limits: No occupational exposure limits established specifically for Bromocriptine Mesylate
Engineering Controls: Handle within chemical fume hood or designated containment area; use HEPA-filter ventilation if powder handling required
Personal Protective Equipment: Lab coat or gown, chemical resistant gloves, safety glasses with side shields or face shield, NIOSH-approved dust respirator for powder
Hand Protection: Nitrile or latex gloves
Eye/Face Protection: Tight-sealing goggles, face shield
Work Hygiene: Immediate cleanup of spills, avoid touching face during handling, frequent hand washing, restrict access to area
Appearance: White to off-white crystalline powder
Odor: Odorless or mild characteristic odor
pH: 4.5-5.5 (1% aqueous solution)
Solubility: Very slightly soluble in water, more soluble in methanol, ethanol, DMSO
Boiling Point: Not applicable, decomposes before boiling
Melting Point: 240–246°C (decomposition)
Vapor Pressure: Negligible under normal conditions
Partition Coefficient (log P): Approximately 3.6
Particle Size: Powder, micronized forms available for pharmaceutical preparation
Evaporation Rate: Not relevant due to low volatility
Chemical Stability: Stable at recommended storage conditions; sensitive to light and moisture exposure
Hazardous Decomposition Products: On heating, releases carbon oxides, nitrogen oxides, sulfur oxides, hydrogen bromide
Reactivity: Not reactive under normal handling or storage conditions; may react with strong oxidizers and acids
Polymerization: Has not been reported to undergo hazardous polymerization
Other Incompatibilities: Avoid mixing with highly reactive chemical agents
Acute Toxicity: Oral LD50 (rat) >180 mg/kg; toxic effects appear at lower doses in sensitive individuals
Chronic Effects: Risk of cardiac valve fibrosis, neuropsychiatric disturbances, gastrointestinal ulceration with prolonged exposure
Corrosivity/Irritation: Mild skin and eye irritant; can provoke allergic skin reactions
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: Possible reproductive hazard; animal studies note effects on fertility and fetal development
Other Health Hazards: Hypotension, insomnia, hallucinations, impulse control disorders reported at higher or chronic pharmaceutical doses
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in aquatic environments
Persistence/Degradability: Not readily biodegradable; slow degradation observed in soil and water environments
Bioaccumulative Potential: Moderate based on log P value and molecular structure
Mobility in Soil: Low mobility expected due to strong binding to soil particles
Other Hazardous Effects: Potential for harmful disruption of aquatic and soil microbial communities
Waste Handling: Collect and place in sealed, appropriately labeled containers for chemical waste
Methods of Disposal: Treat as pharmaceutical (or hazardous) waste in accordance with federal, state, and local requirements
Incineration: Incineration in federally or locally approved facility is preferred; avoid uncontrolled burning
Precautions: Do not discharge into drains, watercourses, or the environment
Contaminated Packaging: Dispose of as chemical waste; triple rinse and puncture before disposal if regulations allow
UN Number: Not classified as dangerous goods by most transport regulations
Proper Shipping Name: Bromocriptine Mesylate
Transport Hazard Class: Not regulated for ground, air, or sea transport
Packing Group: Not applicable
Special Precautions: Prevent material from leaking or breaking during transport, keep container tightly closed and upright; temperature control may be required
OSHA Compliance: Non-hazardous under OSHA Hazard Communication Standard, but use caution as a pharmaceutical active ingredient
TSCA Status: Not listed for commercial use, for pharmaceutical/research use only
DSL/NDSL Status: Not listed on Canadian DSL/NDSL
SARA 313: Not subject to SARA, extremely hazardous chemicals reporting
REACH/CLP: Exempted from registration if used strictly as a medicinal product under appropriate directive
Other Country Regulations: Prescription-only active pharmaceutical ingredient; subject to controlled disposal and handling laws in many regions
Labeling Requirements: European labeling includes risk statements R25 (toxic if swallowed), S22 (do not breathe dust), and S36/37 (wear suitable protective clothing and gloves)
