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Product Name: Bromelain - 200,000 Units
Synonyms: Proteolytic Enzyme, Pineapple Enzyme
Manufacturer: [Company Name, Address, Emergency Contact Number]
Recommended Use: Protein hydrolysis, dietary supplements, pharmaceutical industries
CAS Number: 9001-00-7
EC Number: 232-572-4
Classification: Eye Irritation (Category 2), Respiratory Sensitization (Category 1), Skin Sensitization (Category 1)
Label Elements: Warning signage such as exclamation mark for irritant, health hazard for sensitizer
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms, irritates eyes, may cause skin allergy
Precautionary Statements: Avoid breathing dust, ensure adequate ventilation, wear eye and skin protection
Potential Health Effects: Inhalation leads to coughing or wheezing, powder can irritate eyes or skin, contact may aggravate pre-existing allergies or respiratory conditions
Chemical Name: Bromelain
Concentration: ≥99% enzyme activity base
Enzyme Source: Extracted from stem or fruit of Ananas comosus (pineapple species)
Impurities: Trace levels of moisture, unreacted pineapple components such as carbohydrates, organic acids, and plant matter
Other Components: No preservatives or additives in standard technical grades
Inhalation: Move exposed individual to fresh air, offer medical attention if symptoms like persistent coughing or trouble breathing persist
Skin Contact: Wash area thoroughly with water and mild soap, remove contaminated clothing, seek medical help if irritation or rash develops
Eye Contact: Flush eyes gently for several minutes with plenty of water, remove contact lenses if present, consult medical staff for continued discomfort
Ingestion: Rinse mouth with water, do not induce vomiting, consult medical personnel for any discomfort or unusual symptoms
Most Important Symptoms: Irritation, allergy signs such as swelling or difficulty breathing
Suitable Extinguishing Media: Use water spray, foam, carbon dioxide, or dry powder as needed
Unsuitable Extinguishing Media: High-pressure water sprays may spread powder
Special Hazards: Emits irritating or toxic fumes such as nitrogen oxides, carbon oxides in case of strong heat or fire
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Contain and collect runoff, avoid inhaling combustion fumes, approach upwind
Personal Precautions: Avoid inhaling dust or letting it contact skin and eyes, use respiratory masks, eye protection, gloves
Environmental Precautions: Prevent further leakage, do not allow product to reach surface water, open drains, or soil
Clean-Up Methods: Sweep up gently, avoiding dust, collect for proper disposal using sealed containers, ventilate the area well, clean any remaining traces with water and detergent
Decontamination: Rinse area after clean-up, remove contaminated clothing and wash before reuse
Safe Handling Advice: Minimize dust creation, handle in ventilated environments, use personal protective gear, avoid eating, drinking, or smoking in areas where dust is generated
Safe Storage Practices: Store in cool, dry, well-ventilated place, keep containers tightly sealed, protect from sunlight, avoid exposure to humidity and temperature extremes
Incompatible Materials: Oxidizing agents, strong acids, bases, reduce enzyme stability and activity
General Hygiene: Wash hands before breaks, after handling, and at end of workday
Control Parameters: No established OSHA or ACGIH exposure limits, but use best practices for dust control
Engineering Controls: Local exhaust ventilation, process enclosures for dust containment, eyewash facilities recommended nearby
Personal Protection: Respirators with particle filters (P2/P3), chemical-resistant gloves (nitrile or latex), safety goggles or face shield, protective clothing to prevent skin exposure
Hygiene Measures: Avoid contact with skin, eyes, or clothing, shower after handling, separate contaminated clothing for washing
Physical State: Fine yellowish or off-white powder
Odor: Characteristic faint pineapple scent
pH (1% solution): 4.5 – 7.5
Melting Point: Not applicable, decomposes
Boiling Point: Not applicable, decomposes before boiling
Water Solubility: Soluble
Bulk Density: Ranges from 0.4–0.6 g/cm³
Decomposition Temperature: Above 60°C leads to loss of activity
Other Properties: Generates dust during handling, stable under normal storage conditions
Chemical Stability: Stable under recommended handling and storage
Thermal Stability: Loses enzymatic activity rapidly above 50°C
Hazardous Reactions: None under normal conditions, reacts with strong oxidizers
Conditions to Avoid: Heat, moisture, direct sunlight, and sources of ignition
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides under intense heat
Acute Toxicity: Low toxicity by oral, dermal, and inhalation routes according to available animal studies
Skin Sensitization: Reported in individuals with frequent or prolonged exposure
Respiratory Sensitization: Breathing dust can trigger allergy or asthma in sensitive people
Eye Effects: Irritating to eyes, causes redness or pain in cases of exposure
Chronic Effects: Prolonged or repeated exposure increases risks of allergic reactions
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Toxicity to Aquatic Life: Not expected to be harmful at low concentrations, but large releases can disrupt aquatic enzymatic activity
Persistence and Degradability: Biodegradable, breaks down quickly in the environment
Bioaccumulation: No potential for bioaccumulation due to protein structure
Mobility in Soil: Limited, binds to organic matter, hydrolyzed by microbes
Other Harmful Effects: None identified under foreseeable conditions of use
Disposal Methods: Dispose of in accordance with local, national, and regional regulations as non-hazardous waste
Incineration: Safe method if regulations permit
Contaminated Packaging: Triple rinse and offer for recycling or disposal as non-hazardous
Special Precautions: Clean up residue, avoid dust generation during disposal operations
UN Number: Not classified as hazardous for transportation
Transport Hazard Class: Not regulated
Packing Group: No packing group assigned
Labels Needed: None according to GHS or DOT for enzyme preparations
Special Precautions: Store in sealed packaging, keep dry, shield from excessive heat and direct sun during transit
OSHA Status: Not classified as hazardous according to US OSHA Hazard Communication Standard
TSCA Inventory: Listed
EU Classification: Classified as sensitizer under Regulation (EC) No 1272/2008 (CLP)
SARA Title III: Not listed
DSL (Canada): Listed
Other Regulations: Observe country, regional, and local regulations covering workplace air, food, and enzyme exposures
