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Product Name: Brimonidine Tartrate
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline L-tartrate
CAS Number: 70359-46-5
Molecular Formula: C11H10BrN5•C4H6O6
Molecular Weight: 442.24 g/mol
Use: Active pharmaceutical ingredient in glaucoma and ocular hypertension treatment
Manufacturer: [Company name, address, emergency contact]
Synonyms: Brimonidine hydrogen tartrate, Alphagan ingredient
Recommended Use: Ophthalmic solution preparation
Emergency Contact: [Phone Number, available 24 hours]
GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin sensitization
Signal Word: Warning
Hazard Statements: Harmful if swallowed, May cause skin or eye irritation, Possible respiratory effects if inhaled in powder form
Precautionary Statements: Avoid breathing dust, Use protective gloves and eye protection, Wash affected skin thoroughly after handling, Do not eat, drink, or smoke while using
Pictograms: Exclamation Mark
Potential Health Effects: Headache, increased drowsiness, redness or discomfort at the point of contact
Environmental Hazards: Limited acute aquatic toxicity data; avoid environmental contamination
Carcinogenic Status: Not classified as carcinogenic by IARC, NTP, OSHA
Other Hazards: Dust from large volumes may cause respiratory irritation
Main Ingredient: Brimonidine Tartrate
CAS Number: 70359-46-5
Concentration: >97% (bulk solid)
Impurities: Trace processing-related substances below OHSA or FDA permissible limits
Additives: None for neat substance; formulations may include stabilizers, preservatives, isotonic agents in final products
EC Number: Not assigned
Formula Structure: Includes quinoxaline-based backbone with associated tartrate group
Mixtures: Bulk pharmaceutical is a single-active entity; dust may contain trace processing residues
Inhalation: Move to fresh air, keep comfortable for breathing, seek medical attention if symptoms develop
Skin Contact: Wash with soap and water, remove contaminated clothing, seek medical advice if irritation persists
Eye Contact: Rinse thoroughly with plenty of water for 15 minutes, remove contact lenses, consult an ophthalmologist if discomfort continues
Ingestion: Rinse mouth, never give anything by mouth if unconscious, seek immediate medical advice
Notes for Physician: Provide symptom-based supportive measures, monitor for drowsiness, hypotension, or allergic reaction signs
Other Medical Attention: Observe patient for delayed symptoms, especially low blood pressure or bradycardia
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: Strong water jets may spread powder
Flash Point: Not available for solid Brimonidine Tartrate
Hazardous Combustion Products: Formation of nitrogen oxides, carbon monoxide, hydrogen bromide, possibly irritating organic vapors
Special Protective Equipment: Self-contained breathing apparatus and full protective gear for firefighters
Special Procedures: Cool exposed containers with water spray, prevent runoff into drains and watercourses
Explosion Risk: Low, but fine dust clouds may pose ignition risk in strong oxidizing conditions
Personal Protective Measures: Wear gloves, goggles and dust mask, avoid skin, eye, and respiratory contact
Environmental Precautions: Prevent product from entering surface waters, soil, and drains
Containment Methods: Sweep up spills using non-sparking tools, avoid raising dust, store collected waste in labeled container
Cleanup Procedures: Wipe residual dust with damp cloth, ventilate area, dispose cleanup material as hazardous waste
Notification: Report major releases to appropriate environmental authorities under federal or local requirements
Precautions for Safe Handling: Use in well-ventilated area, avoid dust generation, wear personal protective equipment, handle away from incompatible materials such as oxidizing agents
Hygiene Recommendations: Do not eat, drink, or smoke during handling, always wash hands after use
Storage Conditions: Store in tightly closed original container, protect from moisture and direct sunlight, maintain temperature at 15–30°C (59–86°F)
Incompatible Materials: Strong acids, strong bases, oxidants
Special Storage Requirements: Segregate from foodstuffs, pharmaceuticals in final dosage, and non-compatible chemicals
Container Materials: Use HDPE, amber glass, or lined metal drums for bulk
Engineering Controls: Use laboratory fume hood or local exhaust ventilation, minimize airborne dust
Exposure Limit Values: No established OSHA PEL, ACGIH TLV; apply pharmaceutical industry worker exposure guidelines (OELs: consult company specifications)
Respiratory Protection: Use NIOSH-approved dust mask or respirator for prolonged exposure, especially for dry powders
Skin Protection: Nitrile or latex gloves, lab coat or disposable clothing
Eye/Face Protection: Chemical safety goggles
Environmental Controls: Limit waste or wash water release to drains using containment systems
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (1% solution): Approximately 5.0–6.0
Melting Point: 200–220°C (decomposes)
Solubility: Soluble in water, slightly soluble in ethanol, practically insoluble in non-polar solvents
Partition Coefficient (log Kow): Not determined
Vapor Pressure: Negligible at room temperature
Evaporation Rate: Not applicable (solid)
Flammability: Not classified as flammable
Explosive Properties: Not known to be explosive
Viscosity: Not applicable
Chemical Stability: Stable under standard laboratory conditions and recommended storage
Decomposition: Decomposition occurs above 220°C
Hazardous Reactions: Contact with strong oxidizing agents can generate toxic products
Incompatible Materials: Strong acids, bases, oxidizers
Polymerization: Will not occur
Conditions to Avoid: Excessive heat, high humidity, exposure to direct sunlight
Acute Toxicity: Oral LD50 (rat): >50 mg/kg; toxic in overdose
Routes of Exposure: Oral, dermal, inhalation, eye contact
Chronic Effects: Not extensively studied for chronic exposure in occupational context
Symptoms: Headache, fatigue, respiratory irritation, allergic reaction in sensitive individuals
Sensitization: Rare but possible skin or respiratory sensitization
Carcinogenicity: Not identified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: No evidence of mutagenicity in available studies
Reproductive Toxicity: No confirmed effects in humans
Aquatic Toxicity: Limited data; assume moderate aquatic impact based on chemical class, avoid large-scale release
Persistence/Degradability: Not readily biodegradable, breakdown via slow environmental hydrolysis
Bioaccumulative Potential: Expected to be low due to water solubility and structure
Soil Mobility: Moderate; possible leaching in large spills
Other Adverse Effects: Not classified as environmentally hazardous, prudent to prevent entry to waterways
Methods of Disposal: Incinerate in permitted facility or treat as hazardous waste under local and national regulations
Contaminated Packaging: Rinse containers thoroughly before disposal or return, follow all drum recycling and reconditioning standards
Discharge to Drain: Discouraged; treat effluent as chemical waste
Precautions: Comply with OSHA, FDA, DOT, and EPA guidance on pharmaceutical wastes
UN Number: Not regulated for ground, air, or sea transport in bulk form
Proper Shipping Name: Not classified as dangerous good
Hazard Class: Not applicable
Packing Group: Not assigned
Special Precautions: Keep product in original packaging, secure load to prevent leaks, transport under ambient temperature conditions
Marine Pollutant: No
ADR/RID/IMDG/IATA: Not subject to transport restrictions
Emergency Transport Phone: [Provide as per shipment documentation]
OSHA: Non-hazardous as per OSHA HazCom 2012
TSCA: Not listed (pharmaceutical use exemption)
SARA 313: Not subject to reporting
California Proposition 65: Not listed
REACH (EU): Exempted for active pharmaceutical ingredient, regulatory status may change with new formulations
Other Regulations: Subject to FDA and USP requirements for finished products
Labeling: Strict compliance with pharmaceutical and chemical labeling laws
Chemical Inventory Status: Check regional government lists for latest updates
