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Product Name: Blonanserin Chemical Name: 8-(4-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-yl]butyl)-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Synonyms: BI409306, Lonasen Recommended Use: Antipsychotic pharmaceutical agent Supplier Details: Manufacturer or distributor name, address, and phone (local, not global for better accountability) Emergency Contact Number: Local poison control center or on-site response team CAS Number: 132810-10-7 EC Number: Not listed on EINECS
Classification: Not classified as hazardous under GHS, but may cause irritation or allergic reaction in susceptible individuals Routes of Exposure: Inhalation, ingestion, skin contact, eye contact Acute Effects: Drowsiness, headache, nausea, gastrointestinal upset Chronic Effects: Prolonged exposure may impact central nervous system, endocrine function Pictograms: Not required Precautionary Statements: Avoid ingestion and skin contact, use only in controlled settings Signal Word: None assigned Other Hazards: Dust may form explosive mixtures with air if handled improperly
Substance: Blonanserin Purity: Greater than 98% Impurities: Trace synthesis residuals, less than 2% unspecified Additives: None known Molecular Formula: C28H33N5OS Molecular Weight: 487.67 g/mol
Inhalation: Move person to fresh air. Seek medical attention if symptoms persist. Skin Contact: Wash with soap and water for at least 15 minutes. Remove contaminated clothing. Seek medical evaluation for irritation or allergic responses. Eye Contact: Rinse eyes with plenty of clean water, holding eyelids apart, for at least 15 minutes. Get medical advice. Ingestion: Rinse mouth thoroughly. Give water to dilute only if the person is conscious. Do not induce vomiting. Get urgent medical attention. Most Important Symptoms: Somnolence, agitation, disturbed motor coordination Immediate Medical Attention: Required for any significant ingestion or adverse reaction
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray Specific Hazards: Emits toxic fumes (nitrogen oxides, sulfur oxides, carbon oxides) when heated or burned Protective Equipment: Full protective gear, self-contained breathing apparatus Advice for Firefighters: Prevent run-off from fire control from entering water systems. Approach from upwind to avoid hazardous vapors. Combustion Products: May include hazardous gases—recommend local atmospheric monitoring after fire
Personal Precautions: Use personal protective equipment, such as gloves, lab coats, and eye protection. Avoid dust formation. Environmental Precautions: Prevent release to drains or waterways. Notify environmental personnel if release is significant. Cleanup Methods: Sweep or scoop up dry powder, avoid dust, place in secure labeled containers for disposal as hazardous waste. Decontaminate spill area with water and detergent after removal. Reference to Other Sections: Refer to exposure controls and disposal guidelines for further information
Precautions for Safe Handling: Handle in a well-ventilated area, wear protective gloves and clothing, use dust extraction where possible. Advice on General Hygiene: Wash hands after use, do not eat, drink, or smoke near material Storage Requirements: Store in tightly closed, labeled containers in a cool, dry, ventilated place, away from direct sunlight and incompatible chemicals Incompatibilities: Strong oxidizers, acids, and bases Special Storage Conditions: Use secondary containment for large volumes, ensure access to eyewash and safety shower
Exposure Limits: No established occupational exposure limits Engineering Controls: Laboratory fume hood or local exhaust ventilation to prevent airborne exposure Personal Protective Equipment: Chemical-resistant gloves (nitrile, latex), protective lab coat, safety goggles Respiratory Protection: NIOSH-approved respirator during large-scale handling or if ventilation is inadequate Environmental Controls: Prevent discharge to environment, use closed handling systems for bulk work
Appearance: White to off-white powder Odor: Odorless Odor Threshold: Not applicable pH: Not determined in solid form Melting Point: Approximately 242-246°C Boiling Point: Decomposes before boiling Flash Point: Data not available, presumed above 200°C Solubility: Slightly soluble in water, freely soluble in organic solvents (DMSO, methanol) Vapor Pressure: Negligible at room temperature Partition Coefficient (log Pow): Approx 2.5-3.0 (estimated) Auto-Ignition Temperature: Data not available Density: Approx. 1.2 g/cm³ Other Properties: Stable under normal conditions of storage and use
Chemical Stability: Stable under recommended storage conditions Conditions to Avoid: Moisture, heat, direct sunlight, strong oxidative environments Materials to Avoid: Strong oxidizing agents, strong acids and bases, moisture Hazardous Decomposition Products: Oxides of carbon, nitrogen, and sulfur upon combustion or thermal decomposition Hazardous Reactions: Unlikely under normal circumstances
Acute Toxicity: Oral LD50 (rat): 250-2000 mg/kg (estimated, based on available animal data) Skin Irritation: Possible mild irritation on prolonged contact Eye Irritation: Risk of transient irritation Respiratory Effects: Dust may cause irritation to upper respiratory tract Chronic Toxicity: Repeated exposure may impair cognitive and motor functions, based on pharmacological action Mutagenicity: Not mutagenic in standard bacterial tests Carcinogenicity: No evidence in limited animal studies Teratogenicity/Reproductive Toxicity: Adverse reproductive effects reported in animal studies at high doses Sensitization: Not reported but possible
Toxicity to Aquatic Life: Low to moderate toxicity in aquatic organisms based on chemical class Persistence and Degradability: Not readily biodegradable under environmental conditions Bioaccumulation Potential: Moderate, based on log Pow value Mobility in Soil: Limited by low solubility Other Harmful Effects: Accumulation in the environment poses risk to aquatic organisms and soil invertebrates Precautions: Prevent uncontrolled environmental release, treat spills quickly
Waste Disposal: Collect and dispose of according to local and national regulations for hazardous pharmaceutical waste Methods: Incineration at approved facility preferred, chemical or physical treatment may be used if compatible Packaging Disposal: Decontaminate and dispose of as hazardous material Additional Advice: Do not discharge to drains, soil, or watercourse
UN Number: Not assigned (not classified as dangerous for transport under most regulations) Proper Shipping Name: Not regulated Transport Hazard Class: Not applicable Packing Group: Not applicable Special Precautions: Use robust containers, secure loads to prevent spills Transport Environmental Hazards: None identified for land or air when handled in sealed packaging Regulatory Status: Handle as temperature-sensitive pharmaceutical
Safety, Health, and Environmental Regulations: No specific US OSHA, EU REACH, or GHS hazard designation Pharmaceutical Control Status: Subject to prescription medicine regulations; not for general commercial handling TSCA Inventory: Not listed SARA Title III: Not classified as hazardous State Regulations: Local guidelines for hazardous pharmaceutical compounds may apply Other International Regulations: WHMIS (Canada): Not controlled; EU CLP: Not classified; consult local guidelines for unique requirements
