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Product Name: Bleomycin Sulfate
Chemical Family: Glycopeptide Antibiotic
Chemical Formula: C55H84N17O21S2•xH2SO4
Synonyms: Blenoxane, Bleomycin A2, Bleomycinum Sulphate
CAS Number: 9041-93-4
Intended Use: Chemotherapeutic Agent
Supplier: Pharmaceutical suppliers and research laboratories
Emergency Contact: Refer to local poison control centers or emergency medical services
Classification: Toxic, Carcinogenic Category 2, Mutagenic Category 2, Reproductive Toxicant Category 2
Hazard Statements: Can cause allergy or asthma symptoms or breathing difficulties
Skin contact, inhalation, or ingestion can damage organs and produce severe acute effects
May impair fertility or damage the unborn child
Pictograms: Health Hazard, Exclamation Mark, Skull and Crossbones
Signal Word: Danger
Potential Health Effects: May trigger severe skin or respiratory allergies, lung damage, and other organ toxicities; has known carcinogenic potential
Chemical Name: Bleomycin Sulfate
Concentration: Pure material or in formulated mixtures
Impurities: Trace related glycopeptides or fermentation byproducts
Additives: Often accompanied by stabilizing agents in clinical formulations
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical attention
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and flowing water, consult a physician
Eye Contact: Rinse eyes with water for at least 15 minutes, hold eyelids open, get immediate medical help
Ingestion: Rinse mouth, do not induce vomiting, seek urgent medical care
Most Important Symptoms: Trouble breathing, severe rash or irritation, chest tightness, convulsions
Notes for Physicians: Treat supportively, be alert for delayed pulmonary effects
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Special Hazards: Decomposition releases hazardous fumes like nitrogen oxides, sulfur oxides, and carbon monoxide
Protective Equipment: Firefighters require SCBA and chemical-resistant gear
Additional Actions: Prevent runoff from entering sewers or waterways
Personal Precautions: Wear gloves, goggles, and NIOSH-approved respirator
Environmental Precautions: Avoid discharge to soil or water; contain with dikes or absorbents
Methods for Cleanup: Scoop up solid material using non-sparking tools, collect spillage in sealable containers, clean residue with damp cloth
Decontamination: Wash area thoroughly with soapy water
Handling: Work in a chemical fume hood, limit exposure, prevent dust generation; avoid eating, drinking, or smoking near product
Storage Conditions: Store in original closed container in a secure, well-ventilated, cool, dry area
Segregation: Keep away from incompatible substances like strong oxidizers
Special Precautions: Restrict access to trained personnel, use local exhaust ventilation
Exposure Limits: No specific regulatory exposure limits; minimize to the lowest feasible
Engineering Controls: Use chemical safety hoods, shielded biosafety cabinets for powder work
Personal Protective Equipment: Nitrile gloves, safety goggles, lab coat, respiratory protection when airborne risk exists
Hygiene Measures: Wash hands and forearms after handling; launder contaminated clothing before reuse
Appearance: White to pale yellow amorphous solid
Odor: Odorless
Odor Threshold: Not established
pH (1% solution): 4.5 – 6.0
Melting Point: Decomposes before melting
Boiling Point: Not available
Solubility in Water: Freely soluble
Partition Coefficient (log Kow): Not determined
Vapor Pressure: Negligible
Relative Density: Not available
Evaporation Rate: Not relevant
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: No known dangerous reactions under normal use
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide upon combustion
Routes of Exposure: Skin, eye, inhalation, ingestion
Acute Effects: Severe irritation to airways and mucous membranes, skin sensitization, possible organ toxicity
Chronic Effects: Pulmonary fibrosis, cutaneous adverse effects, potential carcinogenesis
LD50/LC50: Data limited; animal studies indicate significant toxicity at low doses
Cancer, Mutagenicity, Teratogenicity: Studies show mutagenic and teratogenic effects in laboratory models, recognized as a potential human carcinogen
Sensitization: May cause hypersensitivity reactions in susceptible individuals
Ecotoxicity: Harmful to aquatic organisms and may cause long-term adverse effects in aquatic environments
Degradability: Limited information; expected to be persistent in sediment
Bioaccumulation Potential: Low bioaccumulation anticipated based on chemical structure
Mobility in Soil: Likely to move through soil to water sources if released
Other Adverse Effects: Disruption of aquatic microbial balance possible
Waste Methods: Dispose of as hazardous waste through approved chemical disposal firm
Contaminated Packaging: Decontaminate or incinerate in compliance with local regulations
Environmental Precautions: Do not flush to sewer, avoid contaminating soil and water
Additional Notes: Follow institutional or local waste guidelines for cytotoxic drugs
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (Bleomycin sulfate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II (medium danger)
Marine Pollutant: Not classified as marine pollutant
Special Precautions: Package securely, label correctly, transport by authorized channels only
US OSHA: Regulated under Hazard Communication Standard for cytotoxic substances
EU Regulation: Classified as hazardous according to CLP Regulation (EC) No 1272/2008
WHMIS Classification (Canada): Class D2A (very toxic material)
REACH: Subject to registration and restrictions as an active pharmaceutical ingredient
Additional Regulations: Listed under chemical hazard reporting mandates in most regions; reporting thresholds and safe handling guidelines must be followed
