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Product Name: Bismuth Subsalicylate
Synonyms: Bismuth(3+) subsalicylate, Pink Bismuth
Chemical Formula: C7H5BiO4
CAS Number: 14882-18-9
Intended Use: Pharmaceutical active, antacid, anti-diarrheal agent
Manufacturer: Refer to packaging or safety label
Contact Information: Emergency contact found on container or workplace safety posting
Recommended Restrictions: Keep out of reach of children and avoid non-intended usage
GHS Classification: Not classified as hazardous under GHS for consumer products
Signal Word: None, although exposure in large amounts can affect health
Hazard Statements: May cause mild irritation to eyes or skin; accidental ingestion over recommended dose increases risk
Precautionary Statements: Prevent eye contact, avoid inhaling dust or powder, do not eat, drink, or smoke near product, wash hands thoroughly after use
Potential Health Effects: Overexposure linked to tinnitus, black tongue or stool, rarely, salicylate toxicity (ringing in ears, confusion, hyperventilation) in high doses
Environmental hazard: Not expected to pose significant aquatic toxicity, but large spills may disrupt local small bodies of water temporarily
Chemical Name: Bismuth Subsalicylate
Concentration: 100% for pure product; less if in finished medications
Impurities: Pharmaceutical grade materials typically tested for heavy metals, free salicylic acid, and organic contaminants
Molecular Weight: 361.09 g/mol
Eye Contact: Flush eyes immediately with clean water for at least fifteen minutes, lifting eyelids as needed
Skin Contact: Remove contaminated clothing, wash skin with water and soap until residue clears
Inhalation: Move to fresh air; monitor for irritation or difficulty breathing, seek care as needed
Ingestion: Rinse out mouth, seek medical help if unusual symptoms or overdose is suspected
Important Symptoms: Upset stomach, ringing in ears, confusion in overdose cases
Advice to Physician: Treat symptomatically, monitor salicylate levels in severe exposure, provide supportive care
Suitable Extinguishing Media: Water spray, foam, dry chemical, or CO2 are suitable
Unsuitable Media: Do not use high-pressure water jets
Special Hazards: Decomposes to emit irritating fumes when heated to decomposition
Protective Equipment: Self-contained breathing apparatus for firefighters
Explosion Data: Not considered explosive
Special Procedures: Remove containers from area, contain runoff, cool exposed containers with water spray
Personal Precautions: Avoid producing dust, ventilate area if indoors, wear protective equipment
Environmental Precautions: Prevent entry to sewers, surface water, or soil by containing spill
Cleanup Methods: Mechanically collect and place spilled material in labeled container for disposal; avoid dry sweeping to reduce dust generation
Disposal: Follow local regulations, avoid washing large amounts into drains
Decontamination: Wash area with water and mild detergent when cleanup is complete
Safe Handling: Handle in well-ventilated area, minimize dust generation, avoid direct contact with eyes, skin, or clothing
Protection: Use protective gloves and eye protection when handling bulk material
Storage Conditions: Store in a tightly closed container, in cool, dry, well-ventilated location, away from acids and oxidizing agents
Incompatibles: Avoid contact with strong acids, bases, and oxidizers
Other Requirements: Keep out of reach of unauthorized individuals, use only as intended for human health applications
Occupational Limits: No established OSHA, ACGIH, or NIOSH exposure limits for bismuth subsalicylate as a finished medicine
Engineering Controls: Use local exhaust ventilation or work under fume hood if generating dust
Personal Protection: Wear chemical-resistant gloves, safety goggles, lab coat or apron; respiratory protection in case of dust
Hygiene Measures: Avoid eating, drinking, or smoking during handling or in processing areas; wash thoroughly after handling
Special Requirements: Personnel with sensitive skin, history of asthma or allergy to salicylates should take added precautions
Appearance: White to pink powder
Odor: Odorless or very faint salicylic acid-like
pH: Slightly acidic in water suspension
Melting Point: Decomposes before melting
Boiling Point: Not applicable (decomposes)
Solubility: Practically insoluble in water, soluble in hot mineral acids and alkali
Specific Gravity: About 2.4
Vapor Pressure: Negligible at room temperature
Other Properties: Stable under ambient conditions, low volatility
Chemical Stability: Stable at room temperature in sealed containers
Conditions to Avoid: Moisture, high heat, contact with acids, or oxidizing/reducing agents
Incompatible Materials: Strong acids/bases, peroxides, oxidizing agents
Hazardous Decomposition Products: Oxides of bismuth, carbon dioxide, carbon monoxide, salicylic acid fumes on decomposition
Hazardous Polymerization: Does not occur
Routes of Exposure: Ingestion, inhalation of dusts, dermal or eye contact
Acute Toxicity: Not acutely toxic in small doses; large doses may cause salicylate poisoning symptoms
Chronic Exposure: Repeated high-level exposure linked to bismuth accumulation with neurological effects in rare cases
Symptoms: Nausea, vomiting, tinnitus, black/tarry stools, confusion, ataxia with chronic misuse
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Mutagenicity: No reports of relevance at normal exposure
Sensitization: Rarely causes skin or respiratory sensitization
Reproductive Toxicity: Not reported, although excessive salicylate ingestion in pregnancy linked to adverse outcomes
Aquatic Toxicity: Not expected to accumulate or cause lasting harm to aquatic systems at normal levels
Terrestrial Impact: Low potential due to low solubility and bioavailability
Degradability: Not rapidly biodegradable but unlikely to persist in harmful concentrations
Bioaccumulation: Unlikely in common environments; sporadic cases in wildlife from abnormal exposures
Mobility in Soil: Low; tends to remain bound and localized
Ecotoxicological Reports: No major incidents of environmental damage associated with pharmaceutical usage
Disposal Method: Comply with federal, state, and local waste disposal regulations; pharmaceuticals should not be flushed unless guidance provided
Container Disposal: Empty containers may hold residue; treat as contaminated, follow institutional procedures for hazardous drug containers
Special Instructions: Do not landfill large quantities; consult local hazardous waste guidelines
Precaution: Avoid contaminating surface waters; use professional waste disposal services when disposing in bulk settings
UN Number: Not classified as dangerous for transport
Shipping Name: Bismuth Subsalicylate
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: None identified under transport regulations
Special Precautions: Protect against physical damage during transit; keep away from foodstuffs to avoid contamination
TSCA: Listed
DSL/NDSL: Listed in relevant inventories
SARA Title III: Not listed as hazardous
FDA: Approved for OTC oral use within specified limits and labeling
Workplace Safety: OSHA Laboratory Standard applies for bulk or non-consumer use
Labeling Requirements: Use pharmaceutical labeling for consumer products; chemical and safety labeling for raw and bulk forms
Other Standards: Local environmental, workplace, and transportation rules may apply
Compliance Recommendations: Periodically review updates on regulatory status and recommendations due to changes in pharmaceutical safety data
