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Product Name: Bis(Dimethylamino)Phosphoryl Fluoride
Synonyms: N,N-Dimethylphosphanamide fluoride, DMAPF
CAS Number: 17596-08-6
Use: Laboratory chemical, intermediate for organic synthesis
Manufacturer: Supplier’s address and emergency contact phone number provided on label
Recommended Uses: Technical and research applications, not intended for food, drug, or household use
Classification: Acute toxicity (Oral, Dermal, Inhalation), Corrosive to skin and eyes, Respiratory tract irritant
Signal Word: Danger
Hazard Statements: Highly toxic if swallowed, inhaled, or in contact with skin; causes severe skin burns and eye damage; may cause respiratory irritation
Pictograms: Skull and crossbones, Corrosion, Exclamation mark
Precautionary Statements: Wear protective clothing and eye protection; avoid ingestion, inhalation, or contact with skin and eyes; use only outdoors or in a well-ventilated area; wash hands thoroughly after handling
Chemical Name: Bis(Dimethylamino)Phosphoryl Fluoride
Concentration: >2% by weight
Impurities/Other Components: Minor related organophosphorus compounds, solvent or stabilizer if present, none above regulatory thresholds
Molecular Formula: C4H12FN2OP
Molecular Weight: 154.13 g/mol
Inhalation: Remove person to fresh air immediately; seek medical attention without delay; provide artificial respiration if breathing stops; do not leave victim unattended
Skin Contact: Take off contaminated clothing; rinse skin with water for at least 15 minutes; seek immediate medical advice
Eye Contact: Rinse with water for at least 15 minutes, lifting eyelids frequently; remove contact lenses if present; immediate medical attention required
Ingestion: Do not induce vomiting; rinse mouth with water if the person is conscious; seek medical aid at once
Symptoms/Effects: Burning, pain, respiratory distress, headache, convulsion, nausea, chemical burns
Suitable Extinguishing Media: Use dry chemical powder, CO2, or alcohol-resistant foam; avoid water streams
Specific Hazards: Releases toxic and corrosive fumes of phosphorus oxides, nitrogen oxides, fluorides when heated or exposed to fire
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Procedures: Move containers from area if safe, cool with fog to prevent pressure increase; prevent runoff from entering sewers or water sources
Personal Precautions: Evacuate area, ventilate; avoid inhalation and contact; use self-contained breathing apparatus, chemical-resistant gloves, full suit
Environmental Precautions: Prevent powder, dust, or solution from entering drains, surface water, soil, or groundwater
Cleanup Methods: Collect spilled material with inert absorbent; transfer to tightly sealed, chemical-compatible container for disposal; avoid dust formation; decontaminate area thoroughly with soap and water
Handling: Keep container tightly closed; use only in chemical fume hood or approved ventilated area; avoid generating aerosols or dust; no eating or drinking during use; handle with chemical-resistant gloves and eye protection
Storage: Store in original container away from acids, bases, oxidizers; maintain at cool temperature, out of direct sunlight; secure in locked chemical storage facility separate from incompatible substances; label containers clearly with hazard warning
Exposure Limits: No established ACGIH or OSHA exposure limits; minimize exposure by applying strict workplace controls
Engineering Controls: Fume hood or local exhaust ventilation required; safety shower and eyewash station must be accessible
Personal Protective Equipment (PPE): Chemical splash goggles, face shield, flame-resistant lab coat, gloves made from resistant polymers (nitrile, butyl rubber), respiratory protection (full-face respirator or SCBA) for spill or bulk operations
Appearance: Colorless to pale yellow liquid or clear crystalline solid, pungent ammonia-like odor
Boiling Point: 92–97°C (decomposes)
Melting Point: -25°C to -22°C (range varies with purity)
Solubility: Miscible with water and common solvents, may hydrolyze in water
Vapor Pressure: Low at room temperature
Density: 1.09–1.14 g/cm³
pH: Acidic to neutral (aqueous solution)
Flammability: Not highly flammable, can support combustion in fire
Partition Coefficient: Not determined
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to heat, sparks, open flames, humidity, incompatible chemicals
Incompatible Materials: Strong acids, strong bases, oxidizing agents, water (hydrolysis occurs, releasing toxic gases)
Hazardous Decomposition Products: Hydrochloric acid, nitrogen oxides, phosphoric acid, dimethylamine, hydrogen fluoride
Reactivity: Reacts with water, liberates toxic fumes
Routes of Exposure: Inhalation, skin absorption, eye contact, ingestion
Acute Effects: Severe irritation, chemical burns, respiratory tract edema, systemic toxicity
Chronic Effects: Repeated or prolonged contact can cause dermatitis, bronchitis, possible liver or kidney damage
LD50 (Oral, Rat): Data limited; reported range 10–30 mg/kg
Symptoms of Overexposure: Nausea, headache, muscle weakness, confusion, convulsions, risk of fatality after significant exposure
Carcinogenicity: No classification as carcinogen by IARC, NTP, or OSHA
Toxicity: Highly toxic to aquatic organisms; acute and chronic effects on fish and invertebrates
Persistence and Degradability: Undergoes rapid hydrolysis to release phosphates, amines, and fluorides; degradation products persistent
Bioaccumulation: Low potential in higher organisms, high in aquatic or soil microcosms
Mobility in Soil: High; may leach to groundwater
Other Adverse Effects: Releases nutrients that may cause eutrophication in surface water; environmental risk in case of large spill and improper disposal
Waste Disposal: Must be disposed of as hazardous waste in compliance with local, regional, and national regulations; treat or neutralize in controlled, permitted chemical incinerators
Contaminated Packaging: Remove all residues, triple-rinse with copious water, collect rinsate for disposal, label as hazardous
Precautions: Do not discharge into sewers, waterways, or uncontrolled sites; professional waste contractor recommended
UN Number: 2922
DOT Proper Shipping Name: Corrosive Liquid, Toxic, N.O.S. (contains Bis(Dimethylamino)Phosphoryl Fluoride)
Hazard Class: 8 (Corrosive), 6.1 (Toxic)
Packing Group: I (highest danger)
Labels: Toxic, Corrosive
Special Transport Requirements: Use leak-proof, compliant containers; keep away from incompatible goods; emergency response guide available during transport; document and segregate from non-compatible chemicals
U.S. Regulations: Subject to EPA SARA Title III (Sections 302/304/313); listed hazardous substance (40 CFR 355); regulated as toxic and corrosive under OSHA HCS; controlled import/export (TSCA); reporting and handling requirements under CERCLA
European Union: Classified as extremely hazardous; subject to REACH Registration, CLP hazard labeling; transport regulated under ADR/RID
Other International Regulations: Listed in Australia AICS, Canadian DSL/NDSL, Japanese ENCS; consult country-specific legal provisions prior to use or distribution
Worker Protection: Follow all occupational exposure, spill response, and medical surveillance guidance; Safety Data Sheet available for trained staff; maintain records of inventory and incidents
